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Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DRbeta1*03 molecules induces antibody production and protection.

Abstract：

:EBA-175 protein is used as ligand in Plasmodium falciparum binding to erythrocytes. Evidence shows that conserved peptide 1815 from this protein having high red blood cell binding ability plays an important role in the invasion process. This peptide is neither immunogenic nor protective. Residues were substituted by amino acids having similar volume or mass but different polarity in 1815 analogues had to make them fit into HLA-DRbeta1*03 molecules; these were synthesised and inoculated into Aotus monkeys, generating different immunogenic and/or protective immune responses. A shortening in alpha-helix structure was found in the immunogenic and protective ones when their secondary structure was analyzed by NMR to correlate their structure with their immunological properties. This data, together with results from previous studies, suggests that this shortening in high-activity binding peptide (HABP) helical configuration may lead to better fitting into immune system molecules as shown by binding to purified HLA-DRbeta1* molecules rendering them immunogenic and protective and therefore, excellent candidates for consideration as components of a subunit based multi-component synthetic vaccine against malaria.

journal_name

Vaccine

journal_title

Vaccine

authors

Cifuentes G,Salazar LM,Vargas LE,Parra CA,Vanegas M,Cortes J,Patarroyo ME

doi

10.1016/j.vaccine.2004.08.052

subject

Has Abstract

pub_date

2005-02-18 00:00:00

pages

1579-87

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00689-9

journal_volume

23

pub_type

杂志文章

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