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Oral tolerance elicited in mice by beta-lactoglobulin entrapped in biodegradable microspheres.

Abstract：

:Oral administration of antigen is known to be appropriate for some vaccine purposes as well as oral tolerance induction. In the present study, oral administration of beta-lactoglobulin (BLG) loaded poly(D,L-lactide-co-glycolide) (D,L-PLG) microspheres induced tolerance was evaluated. A single feeding of 5 micrograms of encapsulated BLG tolerized BALB/c mice to subsequent BLG parenteral challenge, suppressing the specific humoral, intestinal and cellular responses. The tolerogenic efficient dose was then reduced 10,000 times, compared to oral administration of soluble BLG. This suggests that loading food proteins into D,L-PLG microspheres might be a potential tool for inducing oral tolerance with allergens.

journal_name

Vaccine

journal_title

Vaccine

authors

Pecquet S,Leo E,Fritsché R,Pfeifer A,Couvreur P,Fattal E

doi

10.1016/s0264-410x(99)00384-9

subject

Has Abstract

pub_date

2000-01-18 00:00:00

pages

1196-202

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(99)00384-9

journal_volume

18

pub_type

杂志文章

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