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A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A.

Abstract：

:Clostridium difficile is a pathogen with increasing severity for which host antibody responses provide protection from disease. DNA vaccination has several advantages compared to traditional vaccine methods, however no study has examined this platform against C. difficile toxins. A synthetic gene was created encoding the receptor-binding domain (RBD) of C. difficile toxin A, optimized for expression in human cells. Gene expression was examined in vitro. Mice were inoculated and then challenged with parenteral toxin A. Vaccination provided high titer antibodies and protected mice from death. This represents the first report of DNA vaccine inducing neutralizing antibodies to C. difficile toxin A.

journal_name

Vaccine

journal_title

Vaccine

authors

Gardiner DF,Rosenberg T,Zaharatos J,Franco D,Ho DD

doi

10.1016/j.vaccine.2009.03.058

subject

Has Abstract

pub_date

2009-06-02 00:00:00

pages

3598-604

issue

27

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00482-4

journal_volume

27

pub_type

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