Abstract：
:Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Knock-down or knockout of Prdx-1 expression inhibit influenza A replication. Inhibition of replication is not correlated with defects in initiation of infection or mRNA expression, but is correlated with inhibition of accumulation of viral proteins and vRNAs.
journal_name
Vaccinejournal_title
Vaccineauthors
Dai X,Li N,Roller RJdoi
10.1016/j.vaccine.2018.05.125subject
Has Abstractpub_date
2018-07-16 00:00:00pages
4540-4547issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(18)30823-5journal_volume
36pub_type
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