Abstract:
:In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite of its spectacular results in seropositive patients, high-activity antiretroviral therapy (HAART) cannot eradicate the virus and is faced with side-effects, problems of compliance and the emergence of drug-resistant viruses. Furthermore, its prohibitive cost severely limits its use in developing countries. Therefore, the development of a preventive vaccine remains the best strategy to control the HIV-1 epidemics and a public health priority. However, the development of such a vaccine remains a formidable challenge to both the industry and the scientific community (Burton DR, More JP. Why do we not have an HIV vaccine and how can we make one? Nat Med 1998;4:495-8).
journal_name
Vaccinejournal_title
Vaccineauthors
Klein Mdoi
10.1016/s0264-410x(99)00236-4subject
Has Abstractpub_date
1999-10-01 00:00:00pages
S65-70eissn
0264-410Xissn
1873-2518pii
S0264410X99002364journal_volume
17 Suppl 2pub_type
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