Abstract:
:Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics (e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland, Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts. When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by increasing the discount rate applied to costs and health effects.
journal_name
Vaccinejournal_title
Vaccineauthors
Suárez E,Smith JS,Bosch FX,Nieminen P,Chen CJ,Torvinen S,Demarteau N,Standaert Bdoi
10.1016/j.vaccine.2008.05.069subject
Has Abstractpub_date
2008-09-15 00:00:00pages
F29-45eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00678-6journal_volume
26 Suppl 5pub_type
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