Cost-effectiveness of vaccination against cervical cancer: a multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios.

Abstract:

:Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics (e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland, Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts. When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by increasing the discount rate applied to costs and health effects.

journal_name

Vaccine

journal_title

Vaccine

authors

Suárez E,Smith JS,Bosch FX,Nieminen P,Chen CJ,Torvinen S,Demarteau N,Standaert B

doi

10.1016/j.vaccine.2008.05.069

subject

Has Abstract

pub_date

2008-09-15 00:00:00

pages

F29-45

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00678-6

journal_volume

26 Suppl 5

pub_type

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