Cost-effectiveness of vaccination against cervical cancer: a multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios.


:Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics (e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland, Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts. When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by increasing the discount rate applied to costs and health effects.






Suárez E,Smith JS,Bosch FX,Nieminen P,Chen CJ,Torvinen S,Demarteau N,Standaert B




Has Abstract


2008-09-15 00:00:00










26 Suppl 5




  • Nature, evolution, and appraisal of adverse events and antibody response associated with the fifth consecutive dose of a five-component acellular pertussis-based combination vaccine.

    abstract::We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

    更新日期:2003-06-02 00:00:00

  • Changes in meningococcal C epidemiology and vaccine effectiveness after vaccine introduction and schedule modification.

    abstract:PURPOSE:Meningococcal C conjugate vaccine was included in December 2000 in the Spanish childhood vaccination at 2, 4 and 6 months of age. In 2006, routine vaccination was modified to two doses at 2 and 4-6 months and a booster dose during the second year of age. Additionally, successive catch-up campaigns were launched...


    pub_type: 杂志文章


    authors: Garrido-Estepa M,León-Gómez I,Herruzo R,Cano R

    更新日期:2014-05-07 00:00:00

  • Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer.

    abstract::Carbopol is a polyanionic carbomer gel used in man for a variety of topical applications and drug delivery purposes. Here we show that subcutaneous administration of carbopol with glycoprotein antigens elicits unusually strong specific adaptive immune responses in mice. Recombinant soluble HIV-1 envelope glycoprotein ...


    pub_type: 杂志文章


    authors: Krashias G,Simon AK,Wegmann F,Kok WL,Ho LP,Stevens D,Skehel J,Heeney JL,Moghaddam AE,Sattentau QJ

    更新日期:2010-03-16 00:00:00

  • Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization.

    abstract::In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...


    pub_type: 杂志文章


    authors: Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

    更新日期:1999-03-17 00:00:00

  • A systematic review of national immunization policy making processes.

    abstract::This systematic review aimed to collect and synthesize information available on immunization policy making processes in countries across the globe. Twenty-nine published articles and five websites in either English or French provided varied information on the immunization policy making processes in 33 countries. The i...


    pub_type: 杂志文章,评审


    authors: Bryson M,Duclos P,Jolly A,Bryson J

    更新日期:2010-04-19 00:00:00

  • Efficacy and immunogenicity of high-dose influenza vaccine in older adults by age, comorbidities, and frailty.

    abstract:BACKGROUND:A randomized trial demonstrated that a high-dose inactivated influenza vaccine (IIV-HD) was 24.2% more efficacious than a standard-dose vaccine (IIV-SD) against laboratory-confirmed influenza illness in adults ≥65 years. To evaluate the consistency of IIV-HD benefits, supplemental analyses explored efficacy ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: DiazGranados CA,Dunning AJ,Robertson CA,Talbot HK,Landolfi V,Greenberg DP

    更新日期:2015-08-26 00:00:00

  • Appearance of Fim3 and ptxP3-Bordetella pertussis strains, in two regions of Sweden with different vaccination programs.

    abstract::After introduction of a mono-component vaccine, containing only pertussis toxoid (PT), the incidence of pertussis was significantly higher in the Gothenburg area among children during the period October 1, 1997 until end of 2006 compared to the Rest of Sweden where a vaccine containing PT and two other pertussis antig...


    pub_type: 杂志文章


    authors: Advani A,Gustafsson L,Ahrén C,Mooi FR,Hallander HO

    更新日期:2011-04-18 00:00:00

  • Expected epidemiological impact of the introduction of a partially effective HIV vaccine among men who have sex with men in Australia.

    abstract::A trial of the ALVAC-AIDSVAX HIV vaccine was recently found to be partially effective in preventing HIV transmission among study participants in Thailand. The success of this trial means that vaccination may become a viable intervention for the prevention of HIV infection in the medium-term future. Assuming that the v...


    pub_type: 杂志文章


    authors: Gray RT,Ghaus MH,Hoare A,Wilson DP

    更新日期:2011-08-18 00:00:00

  • Modelling the epidemiological impact of rotavirus vaccination in Germany--a Bayesian approach.

    abstract:BACKGROUND:Rotavirus (RV) infection is the primary cause of severe gastroenteritis in children aged <5 years in Germany and worldwide. In 2013 the German Standing Committee on Vaccination (STIKO) developed a national recommendation for routine RV-immunization of infants. To support informed decision-making we predicted...


    pub_type: 杂志文章


    authors: Weidemann F,Dehnert M,Koch J,Wichmann O,Höhle M

    更新日期:2014-09-08 00:00:00

  • Targeting of rotavirus VP6 to DEC-205 induces protection against the infection in mice.

    abstract::Rotavirus (RV) is the primary etiologic agent of severe gastroenteritis in human infants. Although two attenuated RV-based vaccines have been licensed to be applied worldwide, they are not so effective in low-income countries, and the induced protection mechanisms have not been clearly established. Thus, it is importa...


    pub_type: 杂志文章


    authors: Badillo-Godinez O,Gutierrez-Xicotencatl L,Plett-Torres T,Pedroza-Saavedra A,Gonzalez-Jaimes A,Chihu-Amparan L,Maldonado-Gama M,Espino-Solis G,Bonifaz LC,Esquivel-Guadarrama F

    更新日期:2015-08-20 00:00:00

  • DNA vaccine with α-galactosylceramide at prime phase enhances anti-tumor immunity after boosting with antigen-expressing dendritic cells.

    abstract::DNA vaccines contribute to a promising new approach for the generation of cytotoxic T lymphocytes (CTL). DNA vaccines do have several disadvantages, including poor immunogenicity and oncogene expression. We used the natural killer T-cell (NKT) ligand α-galactosylceramide (α-GalCer) as an adjuvant to prime initial DNA ...


    pub_type: 杂志文章


    authors: Kim D,Hung CF,Wu TC,Park YM

    更新日期:2010-10-21 00:00:00

  • Systems vaccinology: Enabling rational vaccine design with systems biological approaches.

    abstract::Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with sys...


    pub_type: 杂志文章,评审


    authors: Hagan T,Nakaya HI,Subramaniam S,Pulendran B

    更新日期:2015-09-29 00:00:00

  • Impact of introduction of the 9-valent human papillomavirus vaccine on vaccination coverage of youth in North Carolina.

    abstract:OBJECTIVES:The objective of this study was to evaluate the impact of introduction of 9vHPV vaccine on HPV vaccination uptake (doses per capita) and initiation (≥1 doses), completion (≥3 doses) and compliance (≥3 doses within 12 months) by adolescents. METHODS:We used a retrospective cohort analysis using North Carolin...


    pub_type: 杂志文章


    authors: Trogdon JG,Shafer P,Lindsay B,Coyne-Beasley T

    更新日期:2018-02-28 00:00:00

  • Vaccination with recombinant tick antigens for the control of Ixodes scapularis adult infestations.

    abstract::Antigens protective against Ixodes scapularis infestations were identified by cDNA expression library immunization (ELI) and analysis of expressed sequenced tags (EST). Three cDNAs protective against larval tick infestations, 4F8, with homology to a nucleotidase, and 4D8 and 4E6 of unknown function, were characterized...


    pub_type: 杂志文章


    authors: Almazán C,Kocan KM,Blouin EF,de la Fuente J

    更新日期:2005-11-16 00:00:00

  • Behavioral risk assessment in HIV Vaccine Trials Network (HVTN) clinical trials: a qualitative study exploring HVTN staff perspectives.

    abstract::In HIV vaccine trials, the collection and analysis of participant behavior data associated with risk of acquiring HIV-infection is important for a number of reasons. Although the rationale for behavioral risk assessment in HIV vaccine clinical trials is clear, consistent collection of behavioral data over time and acr...


    pub_type: 杂志文章


    authors: Andrasik MP,Karuna ST,Nebergall M,Koblin BA,Kublin JG,NIAID HIV Vaccine Trials Network.

    更新日期:2013-09-13 00:00:00

  • The surface display of haemolysin from Vibrio harveyi on yeast cells and their potential applications as live vaccine in marine fish.

    abstract::HL1 gene encoding haemolysin from Vibrio harveyi SF-1 was expressed in yeast cells and the expressed haemolysin was displayed on the cell surface. After induction for 36h in galactose-containing medium, one-third of the cells contained the displayed protein and the displayed cells had haemolytic activity on erythrocyt...


    pub_type: 杂志文章


    authors: Zhu K,Chi Z,Li J,Zhang F,Li M,Yasoda HN,Wu L

    更新日期:2006-08-28 00:00:00

  • O-acetylation of typhoid capsular polysaccharide confers polysaccharide rigidity and immunodominance by masking additional epitopes.

    abstract::In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according to NMR, the two Vi standards...


    pub_type: 杂志文章


    authors: Hitri K,Kuttel MM,De Benedetto G,Lockyer K,Gao F,Hansal P,Rudd TR,Beamish E,Rijpkema S,Ravenscroft N,Bolgiano B

    更新日期:2019-06-27 00:00:00

  • An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures.

    abstract::Yellow fever is an acute infectious disease caused by prototype virus of the genus Flavivirus. It is endemic in Africa and South America where it represents a serious public health problem causing epidemics of hemorrhagic fever with mortality rates ranging from 20% to 50%. There is no available antiviral therapy and v...


    pub_type: 杂志文章


    authors: Pereira RC,Silva AN,Souza MC,Silva MV,Neves PP,Silva AA,Matos DD,Herrera MA,Yamamura AM,Freire MS,Gaspar LP,Caride E

    更新日期:2015-08-20 00:00:00

  • Improved timely birth dose coverage of hepatitis B vaccine narrows the socio-economic inequality in western China in 2011-2016.

    abstract:OBJECTIVE:To compare timely birth dose (TBD) coverage of hepatitis B vaccine and socio-economic inequality distribution of TBD coverage between 2011 and 2016 in rural areas of western China. METHODS:In western China, using multi-stage probability proportion to size sampling, 2633 and 1929 children aged 0-35 months wit...


    pub_type: 杂志文章


    authors: Liu X,Yang C,Zhong Q,Song Q,Huang X,Yang Y,Huang Y,Wang Y,Zhou H

    更新日期:2018-06-22 00:00:00

  • Animal-associated injuries and related diseases among returned travellers: a review of the GeoSentinel Surveillance Network.

    abstract:BACKGROUND:Increased travel to exotic destinations around the world is escalating the risk of exposure to animal-associated injuries with a risk of acquiring rabies. METHODS:We have examined data reported to GeoSentinel Surveillance Network to highlight characteristics of animal-associated injuries in travellers. RES...


    pub_type: 杂志文章


    authors: Gautret P,Schwartz E,Shaw M,Soula G,Gazin P,Delmont J,Parola P,Soavi MJ,Matchett E,Brown G,Torresi J,GeoSentinel Surveillance Network.

    更新日期:2007-03-30 00:00:00

  • Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant.

    abstract::Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antib...


    pub_type: 杂志文章


    authors: Fatunmbi OO,Newman JA,Sivanandan V,Halvorson DA

    更新日期:1992-01-01 00:00:00

  • A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health.

    abstract:BACKGROUND:A series of state-level statute changes have allowed pharmacists to provide influenza vaccinations in community pharmacies. The study aim was to estimate the effects of pharmacy-based immunization statutes changes on per capita influenza vaccine prescriptions, adult vaccination rates, and the utilization of ...


    pub_type: 杂志文章


    authors: McConeghy KW,Wing C

    更新日期:2016-06-24 00:00:00

  • The role of the vaccines industry in Mission Grand Convergence.

    abstract::The vast majority of vaccines used throughout the world are supplied by the private sector. It is essential therefore that the industry is closely engaged in future policy developments at a national and international level and is able to respond to the changing needs and priorities that may be required to ensure the s...


    pub_type: 杂志文章


    authors: Almond J,Medaglini D

    更新日期:2017-01-20 00:00:00

  • Evaluation of protection in a mouse model after vaccination with Mycobacterium avium subsp. paratuberculois protein cocktails.

    abstract::Whole-cell vaccines successfully reduce signs of clinical disease and fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP), however, these vaccines have some limitations. The present study was conducted to identify MAP proteins that might be candidates for the development of an improved vaccine. MAP pro...


    pub_type: 杂志文章


    authors: Stabel JR,Barnhill A,Bannantine JP,Chang YF,Osman MA

    更新日期:2012-12-17 00:00:00

  • Evaluation of three recombinant multi-antigenic vaccines composed of surface and secretory antigens of Toxoplasma gondii in murine models of experimental toxoplasmosis.

    abstract::The great clinical and economical impact of Toxoplasma gondii infections makes the development of an effective vaccine for controlling toxoplasmosis an extremely important aim. In the presented study, we evaluate the protective and immunogenic properties of three recombinant subunit vaccines composed of rROP2+rGRA4+rS...


    pub_type: 杂志文章


    authors: Dziadek B,Gatkowska J,Brzostek A,Dziadek J,Dzitko K,Grzybowski M,Dlugonska H

    更新日期:2011-01-17 00:00:00

  • Attitudes towards influenza vaccination of multi-nationality health-care workers in Saudi Arabia.

    abstract:BACKGROUND:The compliance with influenza vaccination among health-care workers (HCWs) is known to be low. A multi-nationality survey to explore the reasons for such poor compliance has not been studied in depth. MATERIALS AND METHODS:An epidemiologic survey to evaluate the compliance rates with influenza vaccination a...


    pub_type: 杂志文章


    authors: Al-Tawfiq JA,Antony A,Abed MS

    更新日期:2009-09-04 00:00:00

  • Pertussis immunization in paediatric healthcare workers: knowledge, attitudes, beliefs, and behaviour.

    abstract::Healthcare workers' (HCWs) knowledge, attitudes, and beliefs regarding pertussis immunization were assessed and compared to the rate of vaccine uptake. A questionnaire was distributed to employees at a paediatric and maternity tertiary care centre. Respondents were then offered a dose of the tetanus, diphtheria, and a...


    pub_type: 杂志文章


    authors: Top KA,Halperin BA,Baxendale D,MacKinnon-Cameron D,Halperin SA

    更新日期:2010-03-02 00:00:00

  • Predictive value of seizure ICD-9 codes for vaccine safety research.

    abstract::Post-licensure vaccine safety studies often monitor for seizures using automated screening of ICD-9 codes. This study assessed the positive predictive value (PPV) of ICD-9 codes used to identify seizure visits in children aged 6 weeks to 23 months who were enrolled in seven managed care organizations during January 20...


    pub_type: 杂志文章,多中心研究


    authors: Shui IM,Shi P,Dutta-Linn MM,Weintraub ES,Hambidge SJ,Nordin JD,Lieu TA,Vaccine Safety Datalink Research Team.

    更新日期:2009-08-27 00:00:00

  • Preparation and evaluation of antigen/N-trimethylaminoethylmethacrylate chitosan conjugates for nasal immunization.

    abstract::The frequent outbreak of respiratory infectious diseases such as influenza and pulmonary tuberculosis calls for new immunization strategies with high effectiveness. Nasal immunization is one of the most potential methods to prevent the diseases infected through the respiratory tract. In this study, we designed a water...


    pub_type: 杂志文章


    authors: Liu Q,Zhang C,Zheng X,Shao X,Zhang X,Zhang Q,Jiang X

    更新日期:2014-05-07 00:00:00

  • Generation of recombinant bacillus Calmette-Guérin and Mycobacterium smegmatis expressing BfpA and intimin as vaccine vectors against enteropathogenic Escherichia coli.

    abstract::Enteropathogenic Escherichia coli (EPEC) is an important cause of diarrhea in children. EPEC adheres to the intestinal epithelium and causes attaching and effacing (A/E) lesions. Recombinant Mycobacterium smegmatis (Smeg) and Mycobacterium bovis BCG strains were constructed to express either BfpA or intimin. The entir...


    pub_type: 杂志文章


    authors: Vasconcellos HL,Scaramuzzi K,Nascimento IP,Da Costa Ferreira JM Jr,Abe CM,Piazza RM,Kipnis A,Dias da Silva W

    更新日期:2012-09-07 00:00:00