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Contrasting substitution patterns between HA proteins of avian and human influenza viruses: Implication for monitoring human influenza epidemics.

Abstract：

:The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically comparing the evolutionary dynamics of HA1 between human and avian hosts for both H1N1 and H3N2 viruses. We can thus refine the "positively selected sites" in the HA1 domain of these two virus subtypes to those that occur only in humans. We further demonstrate that the refined sets can accurately reflect influenza epidemics. Our retrospective study shows that when substitutions occur at more than three out of these identified sites in the same year, an epidemic is very likely to occur. Therefore, our approach could potentially be used in determining whether new influenza vaccines are needed.

journal_name

Vaccine

journal_title

Vaccine

authors

Liao YC,Chen FC,Hsiung CA

doi

10.1016/j.vaccine.2010.09.071

subject

Has Abstract

pub_date

2010-11-23 00:00:00

pages

7890-6

issue

50

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)01392-7

journal_volume

28

pub_type

杂志文章

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