Rapid and high seroprotection rates achieved with a tri-antigenic Hepatitis B vaccine in healthy young adults: Results from a Phase IV study.

abstract：:Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...

journal_title：Vaccine

authors： Freed DC,Towne VM,Casimiro DR,Zhao Q,Fu TM

更新日期：2011-11-21 00:00:00

abstract：:Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC repo...

journal_title：Vaccine

authors： Prymula R,Hanovcova I,Splino M,Kriz P,Motlova J,Lebedova V,Lommel P,Kaliskova E,Pascal T,Borys D,Schuerman L

更新日期：2011-02-24 00:00:00

abstract：:A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborns, we co-administered pCSP with a plasmid encoding granulocyte-macroph...

journal_title：Vaccine

authors： Ishii KJ,Weiss WR,Klinman DM

更新日期：1999-11-12 00:00:00

abstract：:The immunoscreening of Brugia malayi adult cDNA library with pooled endemic normal sera identified several seroreactive clones including, EC-SOD which contained a 612 bp insert and showed significant nucleotide and deduced amino acid sequence homologies with superoxide dismutase (SOD) of other nematode parasites. The ...

journal_title：Vaccine

authors： Dabir S,Dabir P,Goswami K,Reddy MV

更新日期：2008-07-04 00:00:00

abstract：:We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA. Mice immunized with the same SIV preparation but boosted with delipidated SIVmac251 exhibited signif...

journal_title：Vaccine

authors： Kitabwalla M,Villinger F,Akeefe H,Liao Z,Mayne AE,Gargano L,Conner AP,Maltais JA,Kunas G,Hildreth JE,Ansari AA,Bellotti M

更新日期：2005-09-07 00:00:00

abstract：BACKGROUND:Most developing countries are implementing the WHO immunisation programme. Although vaccines reach most children, many modifications of the recommended schedule are observed in practice. We investigated the association between vaccination status and risk of hospitalisation in Guinea-Bissau. METHODS:From May...

journal_title：Vaccine

authors： Biai S,Rodrigues A,Nielsen J,Sodemann M,Aaby P

更新日期：2011-05-09 00:00:00

abstract：:Marek's disease virus (MDV) encodes a basic leucine zipper oncoprotein, Meq, which structurally resembles jun/fos family of transcriptional activators. It has been clearly demonstrated that deletion of Meq results in loss of transformation and oncogenic capacity of MDV. The rMd5ΔMeq virus provided superior protection ...

journal_title：Vaccine

authors： Lee LF,Heidari M,Zhang H,Lupiani B,Reddy SM,Fadly A

更新日期：2012-07-20 00:00:00

abstract：:Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search ...

journal_title：Vaccine

authors： Stewart-Tull DE

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compar...

journal_title：Vaccine

authors： Whittaker R,Dias JG,Ramliden M,Ködmön C,Economopoulou A,Beer N,Pastore Celentano L,ECDC network members for invasive meningococcal disease.

更新日期：2017-04-11 00:00:00

abstract：:The induction of oral tolerance against disease-inducing antigens has emerged as a feasible strategy to prevent immunopathologies. In this study, we investigated the effect of oral immunization with whole antigens of Leishmania amazonensis promastigotes (LaAg) on murine cutaneous leishmaniasis. We found that two oral ...

journal_title：Vaccine

authors： Pinto EF,de Mello Cortezia M,Rossi-Bergmann B

更新日期：2003-09-08 00:00:00

abstract：:We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...

journal_title：Vaccine

authors： Ovsyannikova IG,Kennedy RB,O'Byrne M,Jacobson RM,Pankratz VS,Poland GA

更新日期：2012-06-13 00:00:00

abstract：:Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation i...

journal_title：Vaccine

authors： Lewis DJ,Castello-Branco LR,Novotny P,Dougan G,Poulton TA,Griffin GE

更新日期：1993-01-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS-CoV N) is one of the major targets for SARS vaccine due to its high potency in triggering immune responses. In this study, we have identified a novel HLA-A*0201 restricted epitope, N220 (LALLLLDRL), of the SARS-CoV N-protein through bioinform...

journal_title：Vaccine

authors： Cheung YK,Cheng SC,Sin FW,Chan KT,Xie Y

更新日期：2007-08-10 00:00:00

abstract：:Malaria caused by Plasmodium falciparum continues to threaten millions of people living in the tropical parts of the world. A vaccine that confers sterile and life-long protection remains elusive despite more than 30years of effort and resources invested in solving this problem. Antibodies to a malaria vaccine candida...

journal_title：Vaccine

authors： Genito CJ,Beck Z,Phares TW,Kalle F,Limbach KJ,Stefaniak ME,Patterson NB,Bergmann-Leitner ES,Waters NC,Matyas GR,Alving CR,Dutta S

更新日期：2017-07-05 00:00:00

abstract：OBJECTIVE:The Public Health Center Vaccine Survey (PHCVS) examines the knowledge, attitudes, and beliefs about seasonal influenza and H1N1 vaccinations in a largely low-income, urban, public health clinic population in Los Angeles County, USA. DESIGN:A cross-sectional survey of vulnerable individuals at risk for sever...

journal_title：Vaccine

authors： Redelings MD,Piron J,Smith LV,Chan A,Heinzerling J,Sanchez KM,Bedair D,Ponce M,Kuo T

更新日期：2012-01-05 00:00:00

abstract：:A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. B...

journal_title：Vaccine

authors： Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

更新日期：2003-05-16 00:00:00

abstract：:A synthetic T cell immunogen (TCI) has been designed as a candidate DNA-based vaccine against Human immunodeficiency virus (HIV)-1 using cytotoxic T lymphocytes (CD8(+) CTL) and T-helper lymphocytes (CD4(+) Th) epitopes retrieved from the Los Alamos HIV Molecular Immunology Database. The protein 392 amino acids in len...

journal_title：Vaccine

authors： Bazhan SI,Belavin PA,Seregin SV,Danilyuk NK,Babkina IN,Karpenko LI,Nekrasova NA,Lebedev LR,Ignatyev GM,Agafonov AP,Poryvaeva VA,Aborneva IV,Ilyichev AA

更新日期：2004-04-16 00:00:00

abstract：:Recently, an outbreak of fatal infection caused by a pantropic variant (strain CB/05) of canine coronavirus (CCoV) has been reported. In this study, evidence is provided that immunity induced by natural exposure to enteric CCoV is not fully protective against strain CB/05. Twenty-two, 10-week-old beagles with a recent...

journal_title：Vaccine

authors： Decaro N,Elia G,Martella V,Campolo M,Mari V,Desario C,Lucente MS,Lorusso E,Kanellos T,Gibbons RH,Buonavoglia C

更新日期：2010-01-08 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：:We described here the characterization of Schistosoma mansoni egg antigens recognized by human monoclonal antibodies B10 (HmAb-B10) and D5 (HmAb-D5). SDS-PAGE and Western blot analysis revealed that these monoclonals recognized two antigens of M W 44.7/56.8 kDa, with pI of 7.0 and 7.8, respectively. The passive transf...

journal_title：Vaccine

authors： Hirsch C,Almeida CA,Doughty BL,Goes AM

更新日期：1997-06-01 00:00:00

abstract：IMPORTANCE:Disparities in childhood vaccination rates persist. OBJECTIVE:To evaluate the impact of an enriched medical home intervention using community health workers on improving immunization adherence among young children. DESIGN:The intervention group received home visits from trained community health workers to ...

journal_title：Vaccine

authors： Pati S,Ladowski KL,Wong AT,Huang J,Yang J

更新日期：2015-11-17 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：:Vaccine exposure to temperatures below recommended ranges in the cold chain may decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine investments and potentially places children at risk of contracting vaccine preventable illnesses. This literature review is an update to one previously publ...

journal_title：Vaccine

authors： Hanson CM,George AM,Sawadogo A,Schreiber B

更新日期：2017-04-19 00:00:00

abstract：:Dengue is a major infectious disease that affects people living in tropical and subtropical regions around the world. The causative agents are dengue virus serotype 1, 2, 3, and 4 (DENV1, 2, 3, and 4). Developing a vaccine for dengue is a high priority for public health, but traditional methods have faced numerous obs...

journal_title：Vaccine

authors： Pang X,Guo Y,Zhou Y,Fu W,Gu X

更新日期：2014-06-24 00:00:00

abstract：:This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...

journal_title：Vaccine

authors： Leask J,Chapman S,Hawe P,Burgess M

更新日期：2006-11-30 00:00:00

abstract：OBJECTIVE:This study sought to evaluate the acceptability of inactivated influenza vaccine delivered by microneedle patch (MNP) in comparison to inactivated influenza vaccine (IIV) delivered by hypodermic needle. DESIGN, SETTING, AND PARTICIPANTS:From the general population of Atlanta, Georgia, we screened 112 and enr...

journal_title：Vaccine

authors： Frew PM,Paine MB,Rouphael N,Schamel J,Chung Y,Mulligan MJ,Prausnitz MR

更新日期：2020-10-21 00:00:00

abstract：:In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 yea...

journal_title：Vaccine

authors： Dommergues MA,de La Rocque F,Guy C,Lécuyer A,Jacquet A,Guérin N,Fagot JP,Boucherat M,d'Athis P,Cohen R

更新日期：2009-11-23 00:00:00

abstract：:The aim was to develop T cell costimulatory molecules that are broadly applicable to augment anti-tumor immune responses upon application of a virus-modified tumor vaccine to cancer patients. We generated recombinant bispecific single-chain antibodies with one specificity directed against the CD3 or the CD28 antigen o...

journal_title：Vaccine

authors： Haas C,Lulei M,Fournier P,Arnold A,Schirrmacher V

更新日期：2005-03-31 00:00:00

abstract：:Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection ...

journal_title：Vaccine

authors： Bar-On L,Cohen H,Elia U,Rotem S,Bercovich-Kinori A,Bar-Haim E,Chitlaru T,Cohen O

更新日期：2017-12-15 00:00:00

abstract：:Synthetic oligodeoxynucleotides containing CpG immunostimulatory sequences (ISS) have been shown to act as potent adjuvants of type 1 immune responses when co-administered with protein or peptide vaccines. We have recently shown that ISS can increase the anti-polysaccharide (CHO) and anti-tetanus toxoid (TT) or anti-d...

journal_title：Vaccine

authors： von Hunolstein C,Mariotti S,Teloni R,Alfarone G,Romagnoli G,Orefici G,Nisini R

更新日期：2001-04-30 00:00:00