Abstract：
:We previously developed a dengue tetravalent DNA vaccine that can induce neutralizing antibodies against four dengue viruses in mice. Here, we demonstrated that immunogenicity of our tetravalent vaccine is synergistically increased in mice by co-immunization with dengue type 2 virus (DENV2) subviral extracellular particles (D2EPs) or inactivated Japanese encephalitis vaccine (JEVAX). A single immunization with a mixture of 100 microg of the tetravalent vaccine and 150 ng of D2EPs or a 1/10 dose of JEVAX induced moderate levels of neutralizing antibodies in a 90% plaque reduction assay. Immunized mice were protected from "artificial" viremia created by intravenous injection with DENV2.
journal_name
Vaccinejournal_title
Vaccineauthors
Imoto J,Konishi Edoi
10.1016/j.vaccine.2006.09.059subject
Has Abstractpub_date
2007-01-22 00:00:00pages
1076-84issue
6eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)01064-4journal_volume
25pub_type
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