Abstract：
:Bovine papillomaviruses (BPVs) are the causative agent of bovine teat papillomatosis, which can lead to severe economic losses in dairy cattle. Among the 14 identified BPV genotypes, BPV type 6 (BPV6) is the most frequently detected in teat papilloma lesions, and is therefore thought to play a major role in teat papillomatosis. To develop an effective vaccine against BPV6 infection, we produced virus-like particles of BPV6 (BPV6-VLP) in silkworm (Bombyx mori) pupae and purified these by heparin affinity chromatography using a single column. About 0.7mg purified BPV6-VLP was obtained from one pupa. BPV6-VLP-immunized mice produced a specific IgG to BPV6 that recognized BPV6 antigen with high sensitivity in an immunohistochemical analysis. Thus, silkworm pupae are a useful bioreactor for the production of BPV6-VLP, which can potentially be used as a vaccine for bovine teat papillomatosis.
journal_name
Vaccinejournal_title
Vaccineauthors
Watanabe S,Iizuka T,Hatama S,Kanno T,Mase M,Shibahara Tdoi
10.1016/j.vaccine.2017.08.079subject
Has Abstractpub_date
2017-10-13 00:00:00pages
5878-5882issue
43eissn
0264-410Xissn
1873-2518pii
S0264-410X(17)31179-9journal_volume
35pub_type
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