A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major.

abstract：:After massive epidemics of bluetongue disease in 2006 and 2007, Germany has started a compulsory vaccination program against bluetongue virus serotype 8 (BTV-8). Since the available vaccines had not yet been registered and only limited data were available on their performance, a safety study was conducted with three d...

journal_title：Vaccine

authors： Gethmann J,Hüttner K,Heyne H,Probst C,Ziller M,Beer M,Hoffmann B,Mettenleiter TC,Conraths FJ

更新日期：2009-06-24 00:00:00

abstract：:The target animals and vaccination regimes for vaccines against the bovine rhinotracheitis (IBR) and the bovine viral diarrhoea virus (BVDV) are very similar. Therefore, we have compared different schedules for the combined use of a live IBR marker vaccine and an inactivated BVD vaccine. The neutralizing antibody resp...

journal_title：Vaccine

authors： Alvarez M,Bielsa JM,Santos L,Makoschey B

更新日期：2007-09-04 00:00:00

abstract：BACKGROUND:While the size and type of a vaccine container (i.e., primary container) can have many implications on the safety and convenience of a vaccination session, another important but potentially overlooked consideration is how the design of the primary container may affect the distribution of the vaccine, its res...

journal_title：Vaccine

authors： Haidari LA,Wahl B,Brown ST,Privor-Dumm L,Wallman-Stokes C,Gorham K,Connor DL,Wateska AR,Schreiber B,Dicko H,Jaillard P,Avella M,Lee BY

更新日期：2015-06-22 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the number of years after onset of a quadrivalent HPV vaccination program before notable reductions in genital warts and cervical intraepithelial neoplasia (CIN) will occur in teenagers and young adults in the United States. METHODS:We applied a previously publish...

journal_title：Vaccine

authors： Chesson HW,Ekwueme DU,Saraiya M,Dunne EF,Markowitz LE

更新日期：2013-08-20 00:00:00

abstract：:Aluminum in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610.15(a)] limits the amount of aluminum in biological products, including vaccines, to 0.85 m...

journal_title：Vaccine

authors： Baylor NW,Egan W,Richman P

更新日期：2002-05-31 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...

journal_title：Vaccine

authors： Neethling FA,Ramakrishna V,Keler T,Buchli R,Woodburn T,Weidanz JA

更新日期：2008-06-13 00:00:00

abstract：:There is a need for more efficient vaccines to combat viral diseases of Atlantic salmon and other farmed fish. DNA vaccines are highly effective against salmonid rhabdoviruses, but have shown less effect against other viruses. In the present work we have studied if type I IFNs might be used as adjuvants in fish DNA va...

journal_title：Vaccine

authors： Chang CJ,Sun B,Robertsen B

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Combination highly active antiretroviral therapy (HAART) has significantly decreased HIV-1 related morbidity and mortality globally transforming HIV into a controllable condition. HAART has a number of limitations though, including limited access in resource constrained countries, which have driven the searc...

journal_title：Vaccine

authors： Vardas E,Stanescu I,Leinonen M,Ellefsen K,Pantaleo G,Valtavaara M,Ustav M,Reijonen K

更新日期：2012-06-08 00:00:00

abstract：:Protein C deletion mutants of West Nile virus (WNV) were evaluated for their potential use as live virus vaccine candidates in vivo. Double and triple mutants carrying small deletions and second-site point mutations, as well as mutants with large deletions of 36 and 37 amino acid residues were tested in a stringent mo...

journal_title：Vaccine

authors： Schlick P,Kofler RM,Schittl B,Taucher C,Nagy E,Meinke A,Mandl CW

更新日期：2010-08-16 00:00:00

abstract：:Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph. We investigated whether vaccine stability was affected by the presence of trace ...

journal_title：Vaccine

authors： Schlegl R,Weber M,Wruss J,Low D,Queen K,Stilwell S,Lindblad EB,Möhlen M

更新日期：2015-11-04 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS-CoV N) is one of the major targets for SARS vaccine due to its high potency in triggering immune responses. In this study, we have identified a novel HLA-A*0201 restricted epitope, N220 (LALLLLDRL), of the SARS-CoV N-protein through bioinform...

journal_title：Vaccine

authors： Cheung YK,Cheng SC,Sin FW,Chan KT,Xie Y

更新日期：2007-08-10 00:00:00

abstract：:As part of safety monitoring during a group B meningococcal disease vaccination campaign in New Zealand, we examined the possible excess risk of vaccine-associated simple febrile seizures (SFS). We conducted a cohort analysis using data from active hospital-based surveillance in the South Auckland area and a national ...

journal_title：Vaccine

authors： Stehr-Green P,Radke S,Kieft C,Galloway Y,McNicholas A,Reid S

更新日期：2008-02-06 00:00:00

abstract：:Proper vaccination with validated companion differentiation of infected from vaccinated animals (DIVA) tests using a vaccine containing a heterologous neuraminidase to the field virus can be effective to control avian influenza (AI). However, indirect immunofluorescent assay, the only field validated DIVA test, has li...

journal_title：Vaccine

authors： Kwon JS,Kim MC,Jeong OM,Kang HM,Song CS,Kwon JH,Lee YJ

更新日期：2009-05-21 00:00:00

abstract：BACKGROUND:While vaccines not covered by China's Expanded Program on Immunization can be received voluntarily with out-of-pocket payment, the uptake of self-paid vaccines in China is low. OBJECTIVE:To investigate willingness to pay (WTP) for self-paid vaccines and its determinants in China. METHODS:We interviewed 216...

journal_title：Vaccine

authors： Hou Z,Jie Chang,Yue D,Fang H,Meng Q,Zhang Y

更新日期：2014-07-31 00:00:00

abstract：:Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneum...

journal_title：Vaccine

authors： Marsh RL,Smith-Vaughan H,Beissbarth J,Hare K,Kennedy M,Wigger C,Mellon G,Stubbs E,Gadil JR,Pettit A,Mackenzie G,Tipakalippa P,Morris PS,Leach AJ

更新日期：2007-03-22 00:00:00

abstract：:A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by exami...

journal_title：Vaccine

authors： Ferro VA,Costa R,Carter KC,Harvey MJ,Waterston MM,Mullen AB,Matschke C,Mann JF,Colston A,Stimson WH

更新日期：2004-02-25 00:00:00

abstract：:Lyme disease is a major human health problem which continues to increase in incidence and geographic distribution. As a vector-borne zoonotic disease, Lyme disease may be amenable to reservoir targeted strategies for control. We have previously reported that a vaccinia virus (VV) based vaccine expressing outer surface...

journal_title：Vaccine

authors： Bhattacharya D,Bensaci M,Luker KE,Luker G,Wisdom S,Telford SR,Hu LT

更新日期：2011-10-13 00:00:00

abstract：:Targeted delivery of vaccine candidates to the gastrointestinal (GI) tract holds potential for mucosal immunization, particularly against mucosal pathogens like the human immunodeficiency virus (HIV). Among the different strategies for achieving targeted release in the GI tract, namely the small intestine, pH sensitiv...

journal_title：Vaccine

authors： Mercier GT,Nehete PN,Passeri MF,Nehete BN,Weaver EA,Templeton NS,Schluns K,Buchl SS,Sastry KJ,Barry MA

更新日期：2007-12-17 00:00:00

abstract：BACKGROUND:HIV-1 specific cellular immunity plays an important role in controlling viral replication. In this first-in-human therapeutic vaccination study, a replication-defective HIV-1 vaccine (HIVAX) was tested in HIV-1 infected participants undergoing highly active antiretroviral therapy (HAART) to enhance anti-HIV ...

journal_title：Vaccine

authors： Tung FY,Tung JK,Pallikkuth S,Pahwa S,Fischl MA

更新日期：2016-04-27 00:00:00

abstract：:Pertussis vaccine development has mainly focused on Bordetella pertussis, and consequently these vaccines contain B. pertussis antigens only. However, the related species Bordetella parapertussis can also cause pertussis, although symptoms associated with the disease are generally considered to be milder. Recent field...

journal_title：Vaccine

authors： David S,van Furth R,Mooi FR

更新日期：2004-05-07 00:00:00

abstract：:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...

journal_title：Vaccine

authors： Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

更新日期：2002-06-07 00:00:00

abstract：:To test several vaccines for Chlamydia trachomatis we vaccinated BALB/c and C3H/HeN female mice with a purified preparation of the native mouse pneumonitis (MoPn) major outer membrane protein (MOMP). The MOMP was formulated with anyone of three different adjuvants MF59, LT-K63 or LT-R72. As a negative control the anim...

journal_title：Vaccine

authors： Pal S,Peterson EM,Rappuoli R,Ratti G,de la Maza LM

更新日期：2006-02-06 00:00:00

abstract：:Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations tha...

journal_title：Vaccine

authors： Ortiz JR,Neuzil KM,Ahonkhai VI,Gellin BG,Salisbury DM,Read JS,Adegbola RA,Abramson JS

更新日期：2012-11-26 00:00:00

abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

journal_title：Vaccine

authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

更新日期：1997-08-01 00:00:00

abstract：:In case of a bite by a rabies infected animal, the World Health Organisation recommends a prophylactic treatment including the administration of Human Rabies Immunoglobulins (HRIGs) or highly purified F(ab')2 fragments produced from Equine Rabies Immunoglobulin (F(ab')2 - ERIGs). According to international regulation,...

journal_title：Vaccine

authors： Korimbocus J,Dehay N,Tordo N,Cano F,Morgeaux S

更新日期：2016-06-14 00:00:00

abstract：:Rhesus-human rotavirus reassortants incorporating the gene expressing the VP7 surface protein of human rotavirus serotypes 1 or 2, and the remaining ten genes from rhesus rotavirus (RRV) were evaluated as candidate oral vaccines in 2-4-month-old infants. A single dose of the serotype 1 reassortant vaccine which had a ...

journal_title：Vaccine

authors： Vesikari T,Varis T,Green K,Flores J,Kapikian AZ

更新日期：1991-05-01 00:00:00

abstract：:In the present study, we investigated the duration of protection afforded to pigs immunized in two different prime-boost regimens: one is homologus priming and boosting with a protein vaccine, and the other is priming with a DNA vaccine and boosting with the protein vaccine. Groups of pigs that received the same vacci...

journal_title：Vaccine

authors： Guo YJ,Sun SH,Zhang Y,Chen ZH,Wang KY,Huang L,Zhang S,Zhang HY,Wang QM,Wu D,Zhu WJ

更新日期：2004-09-28 00:00:00

abstract：AIM:Design and immunogenicity assessment of the combined vaccine candidate against zoonotic hepatitis E virus (HEV) and foot-and-mouth disease virus (FMDV). METHODS:Using the molecular cloning technology, we produced and purified 9 HEV ORF2-truncated proteins (HEV genotype 4). Then, we compared their thermal stability...

journal_title：Vaccine

authors： Liu Z,Behloul N,Baha S,Wei W,Shi R,Meng J

更新日期：2019-10-31 00:00:00

abstract：:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than...

journal_title：Vaccine

authors： Van Effelterre T,Moore MR,Fierens F,Whitney CG,White L,Pelton SI,Hausdorff WP

更新日期：2010-05-07 00:00:00

abstract：:Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated....

journal_title：Vaccine

authors： Wang L,Barclay T,Song Y,Joyce P,Sakala IG,Petrovsky N,Garg S

更新日期：2017-08-03 00:00:00