Abstract:
:A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.
journal_name
Vaccinejournal_title
Vaccineauthors
Ferro VA,Costa R,Carter KC,Harvey MJ,Waterston MM,Mullen AB,Matschke C,Mann JF,Colston A,Stimson WHdoi
10.1016/j.vaccine.2003.08.043subject
Has Abstractpub_date
2004-02-25 00:00:00pages
1024-31issue
8eissn
0264-410Xissn
1873-2518pii
S0264410X03006741journal_volume
22pub_type
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