Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy.

Abstract:

:A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.

journal_name

Vaccine

journal_title

Vaccine

authors

Ferro VA,Costa R,Carter KC,Harvey MJ,Waterston MM,Mullen AB,Matschke C,Mann JF,Colston A,Stimson WH

doi

10.1016/j.vaccine.2003.08.043

subject

Has Abstract

pub_date

2004-02-25 00:00:00

pages

1024-31

issue

8

eissn

0264-410X

issn

1873-2518

pii

S0264410X03006741

journal_volume

22

pub_type

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