Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy.

Abstract:

:Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec and an aqueous formulation of Map 316F (AquaVax) were tested in sheep. Detailed immunological examination of blood and gut-associated lymphoid tissues was carried out on animals after vaccination and challenge with virulent Map to identify markers of protective immunity. Neoparasec vaccination provided significant protection against disease while AquaVax did not. Immune animals had stronger cell-mediated responses and altered proportions of CD4+, CD8+, CD25+ and B cells in blood, spleen and the gut lymphatics, than diseased animals.

journal_name

Vaccine

journal_title

Vaccine

authors

Begg DJ,Griffin JF

doi

10.1016/j.vaccine.2005.05.031

subject

Has Abstract

pub_date

2005-10-10 00:00:00

pages

4999-5008

issue

42

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00563-3

journal_volume

23

pub_type

临床试验,杂志文章

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