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Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells.

Abstract：

:Influenza B virus infections are mainly restricted to humans, which is partially caused by the inability of influenza B virus NS1 protein to counteract the innate immune response of other species. However, for cell culture-based influenza vaccine production non-human cells, such as Madin-Darby canine kidney (MDCK) cells, are commonly used. Therefore, the impact of cellular pathogen defence mechanisms on influenza B virus propagation in MDCK cells was analysed in this study. Activation of the cellular antiviral defence by interferon stimulation slowed down influenza B virus replication at early time points but after 48h the same virus titres were reached in stimulated and control cells. Furthermore, suppression of the antiviral host defence by transient expression of a viral antagonist, the rabies virus phosphoprotein, could not increase influenza B virus replication. Finally, canine Myxovirus resistance (Mx) proteins showed no antiviral activity in an influenza B virus-specific minireplicon assay in contrast to the murine Mx1 protein. Taken together, these results indicate that an insufficient antiviral defence in MDCK cells promotes efficient influenza B virus replication favouring the use of MDCK cells in influenza vaccine production.

journal_name

Vaccine

journal_title

Vaccine

authors

Frensing T,Seitz C,Heynisch B,Patzina C,Kochs G,Reichl U

doi

10.1016/j.vaccine.2011.05.069

subject

Has Abstract

pub_date

2011-09-22 00:00:00

pages

7125-9

issue

41

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)00816-4

journal_volume

29

pub_type

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