当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Development of a recombinant, chimeric tetravalent dengue vaccine candidate.

Development of a recombinant, chimeric tetravalent dengue vaccine candidate.

Abstract：

:Dengue is a significant threat to public health worldwide. Currently, there are no licensed vaccines available for dengue. Takeda Vaccines Inc. is developing a live, attenuated tetravalent dengue vaccine candidate (TDV) that consists of an attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the prM and E protein genes of DENV-1, -3 and -4 expressed in the context of the attenuated TDV-2 genome backbone (TDV-1, TDV-3, and TDV-4, respectively). TDV has been shown to be immunogenic and efficacious in nonclinical animal models. In interferon-receptor deficient mice, the vaccine induces humoral neutralizing antibody responses and cellular immune responses that are sufficient to protect from lethal challenge with DENV-1, DENV-2 or DENV-4. In non-human primates, administration of TDV induces innate immune responses as well as long lasting antibody and cellular immunity. In Phase 1 clinical trials, the safety and immunogenicity of two different formulations were assessed after intradermal or subcutaneous administration to healthy, flavivirus-naïve adults. TDV administration was generally well-tolerated independent of dose and route. The vaccine induced neutralizing antibody responses to all four DENV serotypes: after a single administration of the higher formulation, 24-67%% of the subjects seroconverted to all four DENV and >80% seroconverted to three or more viruses. In addition, TDV induced CD8(+) T cell responses to the non-structural NS1, NS3 and NS5 proteins of DENV. TDV has been also shown to be generally well tolerated and immunogenic in a Phase 2 clinical trial in dengue endemic countries in adults and children as young as 18 months. Additional clinical studies are ongoing in preparation for a Phase 3 safety and efficacy study.

journal_name

Vaccine

journal_title

Vaccine

authors

Osorio JE,Partidos CD,Wallace D,Stinchcomb DT

doi

10.1016/j.vaccine.2015.11.022

subject

Has Abstract

pub_date

2015-12-10 00:00:00

pages

7112-20

issue

50

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(15)01655-2

journal_volume

33

pub_type

杂志文章,评审

相关文献

VACCINE文献大全
  • Measles vaccination in Africa: by how much could routine coverage be improved?

    abstract：:Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00264-x

    authors： Edmunds WJ,Gay NJ,Henao Restrepo AM,Olivé JM,Bele O

    更新日期：2001-10-12 00:00:00

  • The effect of mass vaccination campaigns against polio on the utilization of routine immunization services: A regression discontinuity design.

    abstract：BACKGROUND:In most low and middle-income countries (LMIC), vaccines are primarily distributed by routine immunization services (RI) at health facilities. Additional opportunities for vaccination are also provided through mass vaccination campaigns, conducted periodically as part of disease-specific initiatives. It is u...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.05.037

    authors： Helleringer S,Asuming PO,Abdelwahab J

    更新日期：2016-07-19 00:00:00

  • Intussusception risk after RotaTeq vaccination: evaluation from worldwide spontaneous reporting data using a self-controlled case series approach.

    abstract：:The increased risk of intussusception after vaccination with the rhesus-human reassortant rotavirus vaccine Rotashield led to its withdrawal in 2005. We assess the risk of intussusception following the pentavalent rotavirus vaccine (RV5) on the basis of worldwide reports to the manufacturer up to May 2014, using a sel...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.01.005

    authors： Escolano S,Hill C,Tubert-Bitter P

    更新日期：2015-02-18 00:00:00

  • Enhancement of intranasal vaccination in mice with deglycosylated chain A ricin by LTR72, a novel mucosal adjuvant.

    abstract：:Intranasal (i.n.) vaccination with two suboptimal doses of 8 microg of deglycosylated chain A ricin (DGCA) stimulated low anti-ricin ELISA IgG and neutralizing antibody responses and the vaccine was only marginally protective against a lethal ricin toxin aerosol challenge. However, in the presence of 4, 2, or 1 microg...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.12.034

    authors： Kende M,Del Giudice G,Rivera N,Hewetson J

    更新日期：2006-03-15 00:00:00

  • Immunogenicity and reactogenicity of co-administered tetanus-diphtheria-acellular pertussis (Tdap) and tetravalent meningococcal conjugate (MCV4) vaccines compared to their separate administration.

    abstract：:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.11.057

    authors： Weston WM,Friedland LR,Wu X,Howe B

    更新日期：2011-01-29 00:00:00

  • Epidemiology and transmission dynamics of the 1918-19 pandemic influenza in Florence, Italy.

    abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.049

    authors： Rizzo C,Ajelli M,Merler S,Pugliese A,Barbetta I,Salmaso S,Manfredi P

    更新日期：2011-07-22 00:00:00

  • Production of antibodies and antibody fragments in plants.

    abstract：:Our current knowledge allows the generation of transgenic plants that efficiently produce heterologous proteins from plant, bacterial, fungal or animal origin. Among all types of recombinant proteins, antibodies are particularly attractive because of their ability to specifically recognize and bind virtually any type ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(00)00514-4

    authors： Peeters K,De Wilde C,De Jaeger G,Angenon G,Depicker A

    更新日期：2001-03-21 00:00:00

  • The fight against rabies in Africa: From recognition to action.

    abstract：:As a follow-up to the first AfroREB meeting, held in Grand Bassam (Côte d'Ivoire) in March 2008, African rabies experts of the AfroREB network met a second time to complete the evaluation of the rabies situation in Africa and define specific action plans. About 40 French speaking rabies specialists from northern, west...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.030

    authors： Dodet B,Africa Rabies Bureau (AfroREB).

    更新日期：2009-08-13 00:00:00

  • How many published cases of serious adverse events after yellow fever vaccination meet Brighton Collaboration diagnostic criteria?

    abstract：OBJECTIVES:To perform a systematic review of all serious adverse events (SAEs) after yellow fever vaccination and to assess them according to Brighton Collaboration criteria. METHODS:Nine electronic databases were searched with the terms "yellow fever vaccine" and "adverse events" to 10 July 2013 (no language/date lim...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2013.10.050

    authors： Thomas RE,Spragins W,Lorenzetti DL

    更新日期：2013-12-16 00:00:00

  • Antibody persistence and booster response in adolescents and young adults 4 and 7.5 years after immunization with 4CMenB vaccine.

    abstract：BACKGROUND:Data on duration of protection against invasive meningococcal disease post-vaccination with the recombinant, 4-component, meningococcal serogroup B vaccine (4CMenB) are limited. We evaluated bactericidal activity persistence in adolescents/young adults up to 7.5 years post-primary vaccination with 4CMenB, an...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2018.12.059

    authors： Nolan T,Santolaya ME,de Looze F,Marshall H,Richmond P,Henein S,Rheault P,Heaton K,Perrett KP,Garfield H,Gupta A,Ferguson M,D'Agostino D,Toneatto D,O'Ryan M

    更新日期：2019-02-21 00:00:00

  • Protection of pigs against Taenia solium cysticercosis using recombinant antigen or in combination with DNA vaccine.

    abstract：:In the present study, we investigated the duration of protection afforded to pigs immunized in two different prime-boost regimens: one is homologus priming and boosting with a protein vaccine, and the other is priming with a DNA vaccine and boosting with the protein vaccine. Groups of pigs that received the same vacci...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.07.012

    authors： Guo YJ,Sun SH,Zhang Y,Chen ZH,Wang KY,Huang L,Zhang S,Zhang HY,Wang QM,Wu D,Zhu WJ

    更新日期：2004-09-28 00:00:00

  • Soluble recombinant human metapneumovirus G protein is immunogenic but not protective.

    abstract：:Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogenicity of GDeltaT...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.04.007

    authors： Ryder AB,Tollefson SJ,Podsiad AB,Johnson JE,Williams JV

    更新日期：2010-06-07 00:00:00

  • DNA vaccination of poultry: The current status in 2015.

    abstract：:DNA vaccination is a promising alternative strategy for developing new human and animal vaccines. The massive efforts made these past 25 years to increase the immunizing potential of this kind of vaccine are still ongoing. A relatively small number of studies concerning poultry have been published. Even though there i...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.11.043

    authors： Meunier M,Chemaly M,Dory D

    更新日期：2016-01-04 00:00:00

  • Long-term persistence of tick-borne encephalitis antibodies in adults 5 years after booster vaccination with Encepur Adults.

    abstract：:Tick-borne encephalitis (TBE) is a potentially serious disease, especially in adults. There is no treatment available for TBE; supportive therapy may help to ease symptoms of the disease. Vaccination is the most effective method of preventing TBE disease and is recommended for those who live, work, or travel in TBE-en...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.11.082

    authors： Plentz A,Jilg W,Schwarz TF,Kuhr HB,Zent O

    更新日期：2009-02-05 00:00:00

  • The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model.

    abstract：:Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.02.006

    authors： Guo S,Yan W,McDonough SP,Lin N,Wu KJ,He H,Xiang H,Yang M,Moreira MA,Chang YF

    更新日期：2015-03-24 00:00:00

  • Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

    abstract：:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00108-7

    authors： Luhrs KA,Fouts DL,Manning JE

    更新日期：2003-06-20 00:00:00

  • Sudden infant death syndrome, attention-deficit/hyperactivity disorder and vaccines: Longitudinal population analyses.

    abstract：:Concerns about a potential link between sudden infant death syndrome (SIDS), attention deficit and hyperactivity disorder (ADHD) and vaccination are unsupported by longitudinal evidence. The analyses employed a multivariate mixed-effects model analyzing data from the National Immunization Survey, School Vaccination As...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.12.065

    authors： Yang YT,Shaw J

    更新日期：2018-01-29 00:00:00

  • Safety and immunogenicity of fully liquid and lyophilized formulations of an investigational trivalent group B streptococcus vaccine in healthy non-pregnant women: Results from a randomized comparative phase II trial.

    abstract：BACKGROUND:We evaluated the safety and immunogenicity of liquid and lyophilized formulations of an investigational trivalent group B streptococcus (GBS) vaccine in non-pregnant women and assessed the formulations' equivalence in terms of serotype-specific immune response. METHODS:This phase II, randomized, comparative...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.02.085

    authors： Beran J,Leroux-Roels G,Van Damme P,de Hoon J,Vandermeulen C,Al-Ibrahim M,Johnson C,Peterson J,Baker S,Seidl C,Dreisbach A,Karsten A,Corsaro B,Henry O,Lattanzi M,Bebia Z

    更新日期：2020-04-03 00:00:00

  • The science of vaccine safety: Summary of meeting at Wellcome Trust.

    abstract：:Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.024

    authors： Plotkin SA,Offit PA,DeStefano F,Larson HJ,Arora NK,Zuber PLF,Fombonne E,Sejvar J,Lambert PH,Hviid A,Halsey N,Garçon N,Peden K,Pollard AJ,Markowitz LE,Glanz J

    更新日期：2020-02-18 00:00:00

  • The epidemiology and burden of rotavirus in China: a review of the literature from 1983 to 2005.

    abstract：:We reviewed studies of rotavirus in MEDLINE and the Chinese literature to get a preliminary estimate of the burden of rotavirus gastroenteritis in China and the epidemiology of the disease. Studies were selected if they were conducted for a period 1 year or more, had more than 100 patients enrolled, and used an accept...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.07.054

    authors： Orenstein EW,Fang ZY,Xu J,Liu C,Shen K,Qian Y,Jiang B,Kilgore PE,Glass RI

    更新日期：2007-01-05 00:00:00

  • Safety and immunogenicity of an 8 year interval heterologous prime-boost influenza A/H7N7-H7N9 vaccination.

    abstract：BACKGROUND:Influenza A/H7N9 viruses are undergoing antigenic drift since their emergence in 2013, and vaccination strategies are needed for pandemic preparedness. Two doses of adjuvanted monovalent inactivated influenza A/H7N9 vaccine (IIV1 A/H7N9) are needed for optimal serological responses. However, administering 2 ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.03.071

    authors： El Sahly HM,Atmar RL,Patel SM,Bellamy A,Liu L,Hong W,Zhu H,Guan Y,Keitel WA,DMID 13-0033 Vaccine Study Group.

    更新日期：2019-05-01 00:00:00

  • GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis.

    abstract：:Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.09.031

    authors： Lu YJ,Leite L,Gonçalves VM,Dias Wde O,Liberman C,Fratelli F,Alderson M,Tate A,Maisonneuve JF,Robertson G,Graca R,Sayeed S,Thompson CM,Anderson P,Malley R

    更新日期：2010-11-03 00:00:00

  • Pertussis after end of a mass vaccination project--end of the "vaccination honey-moon".

    abstract：:After 16 years of no vaccination against pertussis in Sweden, mass vaccination of infants and catch-up vaccination of children up to 10 years with a monocomponent pertussis toxoid vaccine was performed in the Greater Gothenburg area of Sweden between 1995 and 1999. At the end of the project in February 1999, 56% of al...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.01.021

    authors： Trollfors B,Dotevall L,Sundh V,Welinder-Olsson C

    更新日期：2011-03-16 00:00:00

  • Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease.

    abstract：:In this study, West Nile virus (WNV) envelope (rE) protein and its domain III (rDIII) were efficiently expressed in a cost-effective system based on insect larvae as non-fermentative living biofactories. Mice immunized with the partially purified rE or rDIII elicited high antibodies titers that neutralized viral infec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.12.081

    authors： Alonso-Padilla J,de Oya NJ,Blázquez AB,Escribano-Romero E,Escribano JM,Saiz JC

    更新日期：2011-02-17 00:00:00

  • Long-term seropositivity, safety, and impact of inactivated and live, attenuated hepatitis a vaccines in China - A cross-sectional study.

    abstract：BACKGROUND:In 2008, China introduced live, attenuated hepatitis A vaccine (L-HepA, licensed in 1992) and inactivated hepatitis A vaccine (I-HepA, licensed in 2002) nationwide, and is currently the only country using L-HepA in routine immunization. We assessed seropositivity and its duration following vaccination, safet...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.11.019

    authors： Xiaojin S,Rodewald LE,Guomin Z,Hui Z,Ning M,Fuzhen W,Zundong Y

    更新日期：2020-12-14 00:00:00

  • Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections.

    abstract：:Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.07.100

    authors： Clements A,Jenney AW,Farn JL,Brown LE,Deliyannis G,Hartland EL,Pearse MJ,Maloney MB,Wesselingh SL,Wijburg OL,Strugnell RA

    更新日期：2008-10-16 00:00:00

  • Similar long-term vaccine efficacy of two versus three doses of HBV vaccine in early life.

    abstract：:WHO currently recommends three vaccinations against hepatitis B to provide optimal protection against infection and carriage. However, immunological theory and mathematical modelling suggest that similar protection could be induced with two doses, and trials among adolescents and adults have shown comparable rates for...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.10.023

    authors： van der Sande MA,Mendy M,Waight P,Doherty C,McConkey SJ,Hall AJ,Whittle HC

    更新日期：2007-02-09 00:00:00

  • A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia.

    abstract：:Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus toxin associated with skin and soft-tissue infections (SSTIs) and life-threatening necrotizing pneumonia in humans. Recent reports have demonstrated that neutralizing antibody to PVL is not protective against SSTI recurrence, thus raising a controversy about...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.04.033

    authors： Rasigade JP,Sicot N,Laurent F,Lina G,Vandenesch F,Etienne J

    更新日期：2011-06-06 00:00:00

  • No association between HPV vaccination and infertility in U.S. females 18-33 years old.

    abstract：BACKGROUND:Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.03.035

    authors： Schmuhl NB,Mooney KE,Zhang X,Cooney LG,Conway JH,LoConte NK

    更新日期：2020-05-19 00:00:00

  • Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector.

    abstract：:CD8(+) T-cell responses provide beneficial antiviral immunity against human immunodeficiency virus 1 (HIV-1). In this study, we show that intragastric vaccination with a Salmonella HIV-1 Env DNA vaccine vector generates Env-specific CD8(+) T-cells, both in mucosal and systemic lymphoid tissue. By contrast, intramuscul...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00330-9

    authors： Shata MT,Reitz MS Jr,DeVico AL,Lewis GK,Hone DM

    更新日期：2001-11-12 00:00:00