当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Production of antibodies and antibody fragments in plants.

Production of antibodies and antibody fragments in plants.

Abstract：

:Our current knowledge allows the generation of transgenic plants that efficiently produce heterologous proteins from plant, bacterial, fungal or animal origin. Among all types of recombinant proteins, antibodies are particularly attractive because of their ability to specifically recognize and bind virtually any type of antigen. Plants show several advantages as a large-scale antibody production system: they can be grown easily and inexpensively in large quantities that can be harvested, stored and processed by using existing infrastructures. Isolation and purification of plant-made antibodies, if necessary, allow fundamental, industrial, and therapeutical applications. In the past, we and others have successfully generated antibody-producing plants. The maximal accumulation levels of antibodies and antibody fragments that we observed are 1-5% of the extracted proteins. Currently, several biotechnological companies grow field crops to produce antibodies for ex planta applications on an industrial scale.

journal_name

Vaccine

journal_title

Vaccine

authors

Peeters K,De Wilde C,De Jaeger G,Angenon G,Depicker A

doi

10.1016/s0264-410x(00)00514-4

subject

Has Abstract

pub_date

2001-03-21 00:00:00

pages

2756-61

issue

17-19

eissn

0264-410X

issn

1873-2518

pii

S0264410X00005144

journal_volume

19

pub_type

杂志文章,评审

相关文献

VACCINE文献大全
  • Midwives' perceptions of vaccines and their role as vaccinators: The emergence of a new immunization corps.

    abstract：BACKGROUND:In France, midwives have recently been authorized to administer various vaccines to women (including pregnant women), newborns, and their family members. This is expected to enhance vaccine coverage. However, the French high level of vaccine hesitancy is also observed in some healthcare workers. We thus aime...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.06.050

    authors： Massot E,Epaulard O

    更新日期：2018-08-16 00:00:00

  • Reflections on the meningococcal group C infection immunisation campaign: views from the sharp end.

    abstract：:In July 1999, the Department of Health launched a campaign to immunise all children aged from 0-17 years with a new vaccine giving protection against meningococcal group C infection. Following the campaign, a survey of Immunisation Co-ordinators in England was conducted to identify strengths and weaknesses of the camp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00160-9

    authors： Lansley M,Bedford H

    更新日期：2003-06-20 00:00:00

  • An immunogenicity study of a newly introduced purified Vero cell rabies vaccine (Abhayrab) manufactured in India.

    abstract：:Purified Vero cell culture rabies vaccine "Abhayrab" manufactured by Human Biologicals Institute, Ooty, India was subjected for immunogenicity studies. Pre-exposure study was undertaken on 60 healthy volunteers (Group I) with vaccination on days 0, 7 and 21. A group of 75 patients of category II (Group II), 67 of cate...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.08.001

    authors： Sampath G,Reddy SV,Rao ML,Rao YU,Palaniappan C

    更新日期：2005-01-04 00:00:00

  • Evaluation of immunization injection safety in China, 2010: achievements, future sustainability.

    abstract：OBJECTIVE:The study objectives were to evaluate injection practices in China in the post GAVI project era and provide guidance for policy makers to update national standards for injection practices and further improve vaccination services. METHODS:We conducted a national stratified, cross-sectional survey in October 2...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.11.057

    authors： Wu Z,Cui F,Chen Y,Miao N,Gong X,Luo H,Wang F,Zheng H,Kane M,Hadler SC,Hutin YJ,Liang X,Yang W

    更新日期：2013-12-27 00:00:00

  • Specific memory B cell response and participation of CD4+ central and effector memory T cells in mice immunized with liposome encapsulated recombinant NE protein based Hepatitis E vaccine candidate.

    abstract：BACKGROUND:Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. METHODS:The current study in Balb/c mice assessed the levels and ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.046

    authors： Kulkarni SP,Thanapati S,Arankalle VA,Tripathy AS

    更新日期：2016-11-21 00:00:00

  • Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo.

    abstract：:A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium tuberculosis in a prophylactic setting and also therapeutically reduce the number of bacteria in infected mice. The protective mechanism is thought to be related to Th1-mediated events that result in bacterial killing. To determin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00543-7

    authors： Lima KM,dos Santos SA,Santos RR,Brandão IT,Rodrigues JM Jr,Silva CL

    更新日期：2003-12-08 00:00:00

  • Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.

    abstract：:A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00196-6

    authors： Klinguer C,David D,Kouach M,Wieruszeski JM,Tartar A,Marzin D,Levy JP,Gras-Masse H

    更新日期：1999-09-01 00:00:00

  • Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice.

    abstract：:A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. B...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00821-6

    authors： Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

    更新日期：2003-05-16 00:00:00

  • Use of administrative records to assess pneumococcal conjugate vaccine impact on pediatric meningitis and pneumonia hospitalizations in Rwanda.

    abstract：BACKGROUND:Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS:We collected dat...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.08.084

    authors： Gatera M,Uwimana J,Manzi E,Ngabo F,Nwaigwe F,Gessner BD,Moïsi JC

    更新日期：2016-10-17 00:00:00

  • Economic analysis for evidence-based policy-making on a national immunization program: a case of rotavirus vaccine in Thailand.

    abstract：:Severe diarrhea caused by rotavirus is a health problem worldwide, including Thailand. The World Health Organization has recommended incorporating rotavirus vaccination into national immunization programs. This policy has been implemented in several countries, but not in Thailand where the mortality rate is not high. ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.02.047

    authors： Muangchana C,Riewpaiboon A,Jiamsiri S,Thamapornpilas P,Warinsatian P

    更新日期：2012-04-16 00:00:00

  • The purification and protective capacity of Bordetella pertussis outer membrane proteins.

    abstract：:The whole cell vaccine (WCV) of Bordetella pertussis is protective in the intracerebral (i.c.) mouse protection assay. We found a correlation between the i.c. mouse protection assay potency and the presence of the virulence-associated outer membrane proteins (OMPs) in outer membrane complexes (OMC). The virulence-asso...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(94)00040-t

    authors： Hamstra HJ,Kuipers B,Schijf-Evers D,Loggen HG,Poolman JT

    更新日期：1995-01-01 00:00:00

  • Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes.

    abstract：:Genetically modified bacterial flagellin (Fla), a Toll-like receptor-5 (TLR5) ligand, was evaluated as a fusion partner for human papillomavirus (HPV) L2-based immunogens in two animal challenge models; either cutaneous inoculation of rabbits with HPV 'quasivirions' containing cottontail rabbit papillomavirus (CRPV) g...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.04.032

    authors： Kalnin K,Tibbitts T,Yan Y,Stegalkina S,Shen L,Costa V,Sabharwal R,Anderson SF,Day PM,Christensen N,Schiller JT,Jagu S,Roden RB,Almond J,Kleanthous H

    更新日期：2014-06-12 00:00:00

  • Correlation of antibody titres induced by vaccination with protection in mouse typhoid.

    abstract：:The ELISA method was used to titrate the humoral immune response in vaccinated mice. When mice were given two doses of a heat-killed salmonella vaccine 6 days apart, there was a steady but low-level increase of antibody synthesis. In contrast, if a booster vaccination was administered 21 days after the primary inocula...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90256-w

    authors： Xu HR,Hsu HS,Moncure CW,King RA

    更新日期：1993-01-01 00:00:00

  • High rates of serological response to a modified hepatitis B vaccination schedule in HIV-infected adults subjects.

    abstract：:We evaluated a modified HBV regimen in a cohort of HIV-infected subjects in Rio de Janeiro, Brazil. HIV-infected subjects with no serologic evidences of previous hepatitis B infection were immunized with 4 doses (40 microg each) of recombinant hepatitis B vaccine given at 0, 1, 2 and 6 months. Blood samples were colle...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.11.066

    authors： Potsch DV,Oliveira ML,Ginuíno C,Miguel JC,Oliveira SA,Silva EF,Moreira RB,Cruz GV,Oliveira AL,Camacho LA,Barroso PF

    更新日期：2010-02-10 00:00:00

  • The potential cost-effectiveness of acellular pertussis booster vaccination in England and Wales.

    abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00473-x

    authors： Edmunds WJ,Brisson M,Melegaro A,Gay NJ

    更新日期：2002-01-31 00:00:00

  • HPV vaccine efficacy in preventing persistent cervical HPV infection: a systematic review and meta-analysis.

    abstract：INTRODUCTION:We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS:We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS:We selected five studies. The first meta-...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vaccine.2007.09.027

    authors： La Torre G,de Waure C,Chiaradia G,Mannocci A,Ricciardi W

    更新日期：2007-12-05 00:00:00

  • Workshop on intussusception in African countries--meeting report.

    abstract：:Rotavirus causes approximately 450,000 deaths annually among children less than 5 years of age worldwide, almost half of which occur in Africa. After the recent completion of successful trials of 2 new rotavirus vaccines, the World Health Organization has recommended these vaccines for all children worldwide. Because ...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2011.10.004

    authors： Steele AD,Patel M,Cunliffe NA,Bresee JS,Borgstein E,Parashar UD

    更新日期：2012-04-27 00:00:00

  • The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model.

    abstract：:Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.02.006

    authors： Guo S,Yan W,McDonough SP,Lin N,Wu KJ,He H,Xiang H,Yang M,Moreira MA,Chang YF

    更新日期：2015-03-24 00:00:00

  • Hepatitis B vaccination at three months of age: a successful strategy?

    abstract：:Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.01.046

    authors： Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan A

    更新日期：2013-03-25 00:00:00

  • Epidemiology and costs of herpes zoster: background data to estimate the impact of vaccination.

    abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.049

    authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

    更新日期：2007-10-23 00:00:00

  • Design and immunogenicity analysis of the combined vaccine against zoonotic hepatitis E and foot-and-mouth disease.

    abstract：AIM:Design and immunogenicity assessment of the combined vaccine candidate against zoonotic hepatitis E virus (HEV) and foot-and-mouth disease virus (FMDV). METHODS:Using the molecular cloning technology, we produced and purified 9 HEV ORF2-truncated proteins (HEV genotype 4). Then, we compared their thermal stability...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.09.036

    authors： Liu Z,Behloul N,Baha S,Wei W,Shi R,Meng J

    更新日期：2019-10-31 00:00:00

  • Fusion of antigen to Fas-ligand in a DNA vaccine enhances immunogenicity.

    abstract：:DNA vaccines have considerable potential for the prophylaxis and therapy of a range of diseases, but their potential has not been realised largely due to poor immunogenicity. Fas ligand is a pro-apoptotic molecule, able to induce death of Fas expressing cells. We describe the construction of a DNA vaccine encoding a c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.11.059

    authors： Nimal S,Thomas MS,Heath AW

    更新日期：2007-03-08 00:00:00

  • Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults.

    abstract：:Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerat...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2007.04.008

    authors： Moutschen M,Léonard P,Sokal EM,Smets F,Haumont M,Mazzu P,Bollen A,Denamur F,Peeters P,Dubin G,Denis M

    更新日期：2007-06-11 00:00:00

  • Interventions to reduce the burden of vaccine-preventable diseases among migrants and refugees worldwide: A scoping review of published literature, 2006-2018.

    abstract：BACKGROUND:Disparities in vaccine-preventable disease (VPD) burden and immunisation coverage between migrants and refugees and their host populations have been described in numerous countries worldwide. Effective strategies are required to reduce the health disparities and immunisation inequities experienced by migrant...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2020.09.054

    authors： Charania NA,Gaze N,Kung JY,Brooks S

    更新日期：2020-10-27 00:00:00

  • Noncytopathic bovine viral diarrhea virus can persist in testicular tissue after vaccination of peri-pubertal bulls but prevents subsequent infection.

    abstract：:The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.037

    authors： Givens MD,Riddell KP,Walz PH,Rhoades J,Harland R,Zhang Y,Galik PK,Brodersen BW,Cochran AM,Brock KV,Carson RL,Stringfellow DA

    更新日期：2007-01-15 00:00:00

  • Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin.

    abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.11.003

    authors： Tsujita T,Ishii A,Tsukada H,Matsumoto M,Che FS,Seya T

    更新日期：2006-03-15 00:00:00

  • Challenges for the registration of vaccines in emerging countries: Differences in dossier requirements, application and evaluation processes.

    abstract：:The divergence of regulatory requirements and processes in developing and emerging countries contributes to hamper vaccines' registration, and therefore delay access to high-quality, safe and efficacious vaccines for their respective populations. This report focuses on providing insights on the heterogeneity of regist...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2018.03.049

    authors： Dellepiane N,Pagliusi S,Registration Experts Working Group.

    更新日期：2018-06-07 00:00:00

  • Risk factors for human papillomavirus exposure and co-factors for cervical cancer in Latin America and the Caribbean.

    abstract：:The incidence of cervical cancer in Latin America and the Caribbean (LAC) is among the highest in the world. Because there are major demographic shifts happening in LAC countries (population growth, urbanization and ageing) cervical cancer incidence and mortality will likely continue to be a significant public health ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.06.008

    authors： Almonte M,Albero G,Molano M,Carcamo C,García PJ,Pérez G

    更新日期：2008-08-19 00:00:00

  • Frequency and erroneous usage of temporary medical exemptions and knowledge of immunization guidelines among some Miami-Dade County Florida providers.

    abstract：OBJECTIVE:We assessed knowledge and practices regarding immunization guidelines and the Florida Certificate of Immunization (DH-680) based on FL-DOH and CDC recommendations, to identify the cause of the increasing number of erroneously issued temporary medical exemptions (TME) among selected health care providers in Mi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.06.041

    authors： Cruze AR,Zhang G,Thomas L,Alonso J,Sandoval L

    更新日期：2014-07-31 00:00:00

  • Expected epidemiological impact of the introduction of a partially effective HIV vaccine among men who have sex with men in Australia.

    abstract：:A trial of the ALVAC-AIDSVAX HIV vaccine was recently found to be partially effective in preventing HIV transmission among study participants in Thailand. The success of this trial means that vaccination may become a viable intervention for the prevention of HIV infection in the medium-term future. Assuming that the v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.06.061

    authors： Gray RT,Ghaus MH,Hoare A,Wilson DP

    更新日期：2011-08-18 00:00:00