Abstract:
:Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students attending to University of Padova Medical School were enrolled between 2004 and 2011 and HBV antibodies and antigens were measured. The first group (Group A) comprised students vaccinated at three months of age and the second group (Group B) comprised students vaccinated after the first year of life. The follow-up was 18.0 (Group A) and 17.9 (Group B) years. The students vaccinated at three months of age had a higher rate of non-protective antibodies (47.2%) comparing to those vaccinated after the first year of life (17.0%, P<0.0001) with a significantly lower antibody level (P<0.001). The rate of non-protective antibodies was inversely related to vaccination age. The results clearly show that children vaccinated after the first year of life are better protected against HBV. On the other hand, both groups show a good immunological memory as evidenced by the achievement of protective antibody level after the booster dose in 97.8% of subjects.
journal_name
Vaccinejournal_title
Vaccineauthors
Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan Adoi
10.1016/j.vaccine.2013.01.046subject
Has Abstractpub_date
2013-03-25 00:00:00pages
1696-700issue
13eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00114-Xjournal_volume
31pub_type
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