当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Study of integrated protective immunity induced in rhesus macaques by the intradermal administration of a bivalent EV71-CA16 inactivated vaccine.

Study of integrated protective immunity induced in rhesus macaques by the intradermal administration of a bivalent EV71-CA16 inactivated vaccine.

Abstract：

:Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are recognized as the major pathogens responsible for human hand-foot-mouth disease. To develop a bivalent EV71-CA16 vaccine, rhesus macaques immunized with two doses of this vaccine via the intradermal route were challenged with EV71 or CA16, and their clinical symptoms, viral shedding, neutralizing antibodies, IFN-γ-specific ELISpots, and tissue viral load were examined longitudinally. Specific immunity against EV71 and CA16 was observed in the macaques, which exhibited controlled proliferation of the EV71 and CA16 viruses and upregulated expression of immune-related genes compared with the controls. Furthermore, broad protection against EV71 and CA16 challenge without immunopathological effects was observed in all the immunized macaques. These studies suggest that the bivalent EV71-CA16 inactivated vaccine was effective against wild-type EV71 or CA16 viral challenge in rhesus macaques.

journal_name

Vaccine

journal_title

Vaccine

authors

Fan S,Liao Y,Jiang G,Jiang L,Wang L,Xu X,Feng M,Yang E,Zhang Y,Cui W,Li Q

doi

10.1016/j.vaccine.2019.12.057

subject

Has Abstract

pub_date

2020-02-18 00:00:00

pages

2034-2044

issue

8

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(19)31721-9

journal_volume

38

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Quadrivalent meningococcal conjugate vaccines.

    abstract：:Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2009.05.003

    authors： Pace D,Pollard AJ,Messonier NE

    更新日期：2009-06-24 00:00:00

  • Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system.

    abstract：INTRODUCTION:Replication-competent vaccinia viruses (VACVs) show prolonged antigen expression time and greater stimulation of immune responses than their replication-incompetent counterparts. However, there is the potential risk of serious post-vaccination complications, especially for children and immunocompromised in...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.05.012

    authors： Zhang Q,Liu Z,Hou J,Wang S,Liu C,Wei M,Liu Y,Shao Y

    更新日期：2016-06-24 00:00:00

  • Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease virus.

    abstract：:To evaluate the usefulness of a DNA vaccine for chickens, we constructed a plasmid vector expressing the Newcastle disease virus F protein (NDV-F) under the control of the human cytomegalovirus immediate early enhancer and chicken beta-actin gene promoter. One-week-old chickens injected intramusculary with the circula...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)00254-x

    authors： Sakaguchi M,Nakamura H,Sonoda K,Hamada F,Hirai K

    更新日期：1996-06-01 00:00:00

  • Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination.

    abstract：:The World Health Organization's Expanded Programme on Immunization has led to a dramatic rise in worldwide vaccination rates over the past 40years, yet 19.4 million infants remain underimmunized each year. Many of these infants have received at least one vaccine dose but may remain unprotected because they did not rec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.094

    authors： Guarecuco R,Lu J,McHugh KJ,Norman JJ,Thapa LS,Lydon E,Langer R,Jaklenec A

    更新日期：2018-05-24 00:00:00

  • Introduction to the supplement.

    abstract：:In July of 2014, a symposium entitled "Enhancing Vaccine Immunity and Value" was held in Siena, Italy. The focus of the symposium was on how to best meet the challenge of developing and implementing vaccines for future disease targets. Vaccination has been responsible for averting estimated 3 billion cases of disease ...

    journal_title：Vaccine

    pub_type： 社论

    doi：10.1016/j.vaccine.2015.02.072

    authors： Rappuoli R

    更新日期：2015-06-08 00:00:00

  • Assessing vaccine potency using TCRmimic antibodies.

    abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.02.025

    authors： Neethling FA,Ramakrishna V,Keler T,Buchli R,Woodburn T,Weidanz JA

    更新日期：2008-06-13 00:00:00

  • Parent "cocoon" immunization to prevent pertussis-related hospitalization in infants: the case of Piemonte in Italy.

    abstract：:Pertussis incidence in Piemonte (Italy) is now at the lowest level ever reached (0.85 per 100,000 in 2010) but the disease is still endemic in infants (54 per 100,000 in 2005-2010). Parental "cocoon" immunization has been proposed in some countries (i.e. United States, France) as a measure to protect newborns from ser...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.12.061

    authors： Meregaglia M,Ferrara L,Melegaro A,Demicheli V

    更新日期：2013-02-06 00:00:00

  • Comparison of adjuvants to optimize influenza neutralizing antibody responses.

    abstract：:Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continual influenza evolution and its ability to evade immunity pose a constant threat. For these reasons, vaccines with improved potency and breadth of protection remain an important need. We ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.08.030

    authors： Rudicell RS,Garinot M,Kanekiyo M,Kamp HD,Swanson K,Chou TH,Dai S,Bedel O,Simard D,Gillespie RA,Yang K,Reardon M,Avila LZ,Besev M,Dhal PK,Dharanipragada R,Zheng L,Duan X,Dinapoli J,Vogel TU,Kleanthous H,Mascola J

    更新日期：2019-09-30 00:00:00

  • Safe vaccination of children with a virosomal adjuvanted influenza vaccine.

    abstract：:A post-marketing study was conducted in 26 paediatric practices in Germany to collect safety information on the virosomal adjuvanted influenza vaccine Inflexal V (in Germany marketed as Infectovac Flu). Children aged 6 months to 6 years received one or two doses. Adverse events were documented by parents/legal guardia...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.12.008

    authors： Künzi V,Dornseiff M,Horwath J,Hartmann K

    更新日期：2009-02-18 00:00:00

  • Safety and immunogenicity of a new formulation of an inactivated hepatitis A vaccine.

    abstract：:The safety and immunogenicity of a new formulation of the inactivated hepatitis A vaccine, Avaxim, was evaluated in 189 children, aged 18 months to 15 years in a monocentric, open trial. Two vaccinations were given six months apart. Enrollment was balanced within three age groups: 18 months to 3 years, 4-8 years and 9...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0264-410x(98)00461-7

    authors： Dagan R,Greenberg D,Goldenbertg-Gehtman P,Vidor E,Briantais P,Pinsk V,Athias O,Dumas R

    更新日期：1999-04-09 00:00:00

  • Antigen encoded by vaccine vectors derived from human adenovirus serotype 5 is preferentially presented to CD8+ T lymphocytes by the CD8α+ dendritic cell subset.

    abstract：:Different subsets of dendritic cells (DC) elicit qualitatively different immune responses. In mice, two lymphoid tissue-resident subsets, CD8α(+) and CD8α(-), have been implicated in the induction of T helper 1 (Th1) or Th2 responses, respectively. Moreover, CD8α(+) DC appear to play a major role in priming CD8(+) T l...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.06.071

    authors： Suleman M,Galea S,Gavard F,Merillon N,Klonjkowski B,Tartour E,Richardson J

    更新日期：2011-08-11 00:00:00

  • Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na.

    abstract：:Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major cau...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00064-5

    authors： Goestch L,Plotnicky-Gilquin H,Champion T,Beck A,Haeuw JF,Nguyen T,Bonnefoy JY,Corvaïa N

    更新日期：2000-06-01 00:00:00

  • A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination.

    abstract：OBJECTIVE:To determine human papillomavirus (HPV) prevalence and type-distribution in women from South Asia, with and without cervical lesions, in order to estimate the impact of an HPV 16/18 prophylactic vaccine in this region and to assess additional types that should be incorporated in new vaccines. METHODS:A meta-...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.03.047

    authors： Bhatla N,Lal N,Bao YP,Ng T,Qiao YL

    更新日期：2008-06-02 00:00:00

  • Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines.

    abstract：:Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-based vaccine that provides high-grade, durable protection against infection with Pf malaria. Several candidate vaccines ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.09.096

    authors： Richie TL,Billingsley PF,Sim BK,James ER,Chakravarty S,Epstein JE,Lyke KE,Mordmüller B,Alonso P,Duffy PE,Doumbo OK,Sauerwein RW,Tanner M,Abdulla S,Kremsner PG,Seder RA,Hoffman SL

    更新日期：2015-12-22 00:00:00

  • An assessment of shedding with the oral rabies virus vaccine strain SPBN GASGAS in target and non-target species.

    abstract：:A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the env...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.12.076

    authors： Vos A,Freuling C,Ortmann S,Kretzschmar A,Mayer D,Schliephake A,Müller T

    更新日期：2018-02-01 00:00:00

  • Impact of pneumococcal conjugate vaccine in children morbidity and mortality in Peru: Time series analyses.

    abstract：:Streptococcus pneumoniae is the leading cause of bacterial pneumonia, meningitis and sepsis in children worldwide. Despite available evidence on pneumococcal conjugate vaccine (PCV) impact on pneumonia hospitalizations in children, studies demonstrating PCV impact in morbidity and mortality in middle-income countries ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.07.027

    authors： Suarez V,Michel F,Toscano CM,Bierrenbach AL,Gonzales M,Alencar AP,Ruiz Matus C,Andrus JK,de Oliveira LH

    更新日期：2016-09-07 00:00:00

  • From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination.

    abstract：:Although studies have suggested that a patient's perceived cost-benefit of a medical intervention could affect his or her utilization of the intervention, the economic value of influenza vaccine from the patient's perspective remains unclear. Therefore, we developed a stochastic decision analytic computer model repres...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.12.078

    authors： Lee BY,Bacon KM,Donohue JM,Wiringa AE,Bailey RR,Zimmerman RK

    更新日期：2011-03-03 00:00:00

  • Achieving a "Grand Convergence" in global health by 2035.

    abstract：:Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.085

    authors： Mahmoud A

    更新日期：2017-01-20 00:00:00

  • The science of vaccine safety: Summary of meeting at Wellcome Trust.

    abstract：:Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.024

    authors： Plotkin SA,Offit PA,DeStefano F,Larson HJ,Arora NK,Zuber PLF,Fombonne E,Sejvar J,Lambert PH,Hviid A,Halsey N,Garçon N,Peden K,Pollard AJ,Markowitz LE,Glanz J

    更新日期：2020-02-18 00:00:00

  • Immunogenicity of a DNA vaccine against herpes B virus in mice and rhesus macaques.

    abstract：:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00232-8

    authors： Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

    更新日期：2001-09-14 00:00:00

  • Long-term seropositivity, safety, and impact of inactivated and live, attenuated hepatitis a vaccines in China - A cross-sectional study.

    abstract：BACKGROUND:In 2008, China introduced live, attenuated hepatitis A vaccine (L-HepA, licensed in 1992) and inactivated hepatitis A vaccine (I-HepA, licensed in 2002) nationwide, and is currently the only country using L-HepA in routine immunization. We assessed seropositivity and its duration following vaccination, safet...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.11.019

    authors： Xiaojin S,Rodewald LE,Guomin Z,Hui Z,Ning M,Fuzhen W,Zundong Y

    更新日期：2020-12-14 00:00:00

  • MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice.

    abstract：BACKGROUND:By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the e...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.03.020

    authors： Davtyan H,Chen WW,Zagorski K,Davis J,Petrushina I,Kazarian K,Cribbs DH,Agadjanyan MG,Blurton-Jones M,Ghochikyan A

    更新日期：2017-04-11 00:00:00

  • Impact of introduction of the 9-valent human papillomavirus vaccine on vaccination coverage of youth in North Carolina.

    abstract：OBJECTIVES:The objective of this study was to evaluate the impact of introduction of 9vHPV vaccine on HPV vaccination uptake (doses per capita) and initiation (≥1 doses), completion (≥3 doses) and compliance (≥3 doses within 12 months) by adolescents. METHODS:We used a retrospective cohort analysis using North Carolin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.01.013

    authors： Trogdon JG,Shafer P,Lindsay B,Coyne-Beasley T

    更新日期：2018-02-28 00:00:00

  • Expansion of syndromic vaccine preventable disease surveillance to include bacterial meningitis and Japanese encephalitis: evaluation of adapting polio and measles laboratory networks in Bangladesh, China and India, 2007-2008.

    abstract：BACKGROUND:Surveillance for acute flaccid paralysis with laboratory confirmation has been a key strategy in the global polio eradication initiative, and the laboratory platform established for polio testing has been expanded in many countries to include surveillance for cases of febrile rash illness to identify measles...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.01.004

    authors： Cavallaro KF,Sandhu HS,Hyde TB,Johnson BW,Fischer M,Mayer LW,Clark TA,Pallansch MA,Yin Z,Zuo S,Hadler SC,Diorditsa S,Hasan AS,Bose AS,Dietz V,AMES Study Group.

    更新日期：2015-02-25 00:00:00

  • Immunization with a cocktail of antigens fused with OprI reduces Neospora caninum vertical transmission and postnatal mortality in mice.

    abstract：:OprI is an outer membrane lipoprotein from Pseudomonas aeruginosa, and when fused to a recombinant antigen, will exert adjuvant properties by engaging Toll-like receptor 2, leading to dendritic cell activation. Previous studies have shown that the Neospora caninum (Nc) antigens NcPDI, NcROP2 and NcROP40 are implicated...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.060

    authors： Aguado-Martínez A,Basto AP,Tanaka S,Ryser LT,Nunes TP,Ortega-Mora LM,Arranz-Solís D,Leitão A,Hemphill A

    更新日期：2019-01-14 00:00:00

  • An assessment of risk compensation and spillover behavioural adaptions associated with the use of vaccines in animal disease management.

    abstract：:This paper analyses farmers' behavioural responses to Government attempts to reduce the risk of disease transmission from badgers to cattle through badger vaccination. Evidence for two opposing behavioural adaptions is examined in response to the vaccination of badgers to reduce the risk of transmission to farmed catt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.037

    authors： Enticott G,Maye D,Naylor R,Brunton L,Downs SH,Donnelly CA

    更新日期：2020-01-29 00:00:00

  • Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations.

    abstract：:Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.09.122

    authors： Freed DC,Towne VM,Casimiro DR,Zhao Q,Fu TM

    更新日期：2011-11-21 00:00:00

  • Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season.

    abstract：BACKGROUND:The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage influenza viruses. The components of the vaccines used in the current and past two seasons in the Valencia region were similar but not well matched to the 2015/2016 dominant influen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.100

    authors： Puig-Barberà J,Guglieri-López B,Tortajada-Girbés M,López-Labrador FX,Carballido-Fernández M,Mollar-Maseres J,Schwarz-Chavarri G,Baselga-Moreno V,Mira-Iglesias A,Díez-Domingo J,Valencia Hospital Network for the Study of Influenza, Res

    更新日期：2017-12-19 00:00:00

  • Risk factors for human papillomavirus exposure and co-factors for cervical cancer in Latin America and the Caribbean.

    abstract：:The incidence of cervical cancer in Latin America and the Caribbean (LAC) is among the highest in the world. Because there are major demographic shifts happening in LAC countries (population growth, urbanization and ageing) cervical cancer incidence and mortality will likely continue to be a significant public health ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.06.008

    authors： Almonte M,Albero G,Molano M,Carcamo C,García PJ,Pérez G

    更新日期：2008-08-19 00:00:00

  • An LASV GPC pseudotyped virus based reporter system enables evaluation of vaccines in mice under non-BSL-4 conditions.

    abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.07.101

    authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

    更新日期：2017-09-12 00:00:00