Abstract：
:Because of the serious economic and medical consequences of brucellosis, efforts are to prevent infection of domestic animals through vaccines. Many disadvantages are associated with the current Brucella melitensis Rev.1 vaccine prompting development of alternative vaccines and delivery. Escherichia coli (DH5α) was engineered to express a plasmid containing the inv gene from Yersinia pseudotuberculosis and the hly gene from Listeria monocytogenes. These recombinant invasive E. coli expressing B. melitensis outer membrane proteins (Omp31 or 16) or the periplasmic protein BP26 were evaluated for protection of mice against virulent B. melitensis. Importantly, these invasive E. coli vaccines induced significant protection against B. melitensis challenged mice. Invasive E. coli may be an ideal vaccine platform with natural adjuvant properties for application against B. melitensis since the E. coli delivery system is non-pathogenic and can deliver antigens to antigen-presenting cells promoting cellular immune responses.
journal_name
Vaccinejournal_title
Vaccineauthors
Gupta VK,Radhakrishnan G,Harms J,Splitter Gdoi
10.1016/j.vaccine.2012.04.036subject
Has Abstractpub_date
2012-06-08 00:00:00pages
4017-22issue
27eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)00567-1journal_volume
30pub_type
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