当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction.

Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction.

Abstract：

:Nitric oxide (NO) mediated mechanisms have been implicated in killing of some life-stages of Brugia malayi/Wuchereria bancrofti and protect the host through type 1 responses and IFN-γ stimulated toxic mediators' release. However, the identity of NO stimulating molecules of the parasites is not known. Three predominantly NO-stimulating SDS-PAGE resolved fractions F8 (45.24-48.64 kDa), F11 (33.44-38.44 kDa) and F12 (28.44-33.44 kDa) from B. malayi were identified and their proteins were analyzed by 2-DE and MALDI-TOF/TOF. Tropomyosin, calponin and de novo peptides were identified by 2-DE and MALDI-TOF/TOF in F8 and immunization with F8 conferred most significant protection against L3-initiated infection in Mastomys coucha. Immunized animals showed upregulated F8-induced NO, IFN-γ, TNF-α, IL-1β, IL-10, TGF-β release, cellular proliferative responses and specific IgG and IgG1. Anti-IFN-γ, anti-TNF-α, and anti-IL-1β significantly reduced F8-mediated NO generation and iNOS induction at protein levels. Anti-IFN-γ treated cells showed maximum reduction (>74%) in NO generation suggesting a predominant role of IFN-γ in iNOS induction. In conclusion, the findings suggest that F8 which contains tropomyosin, calponin and de novo peptides protects the host via IFN-γ mediated iNOS induction and may hold promise as vaccine candidate(s). This is also the first report of identification of tropomyosin and calponin in B. malayi.

journal_name

Vaccine

journal_title

Vaccine

authors

Verma SK,Joseph SK,Verma R,Kushwaha V,Parmar N,Yadav PK,Thota JR,Kar S,Murthy PK

doi

10.1016/j.vaccine.2014.11.041

subject

Has Abstract

pub_date

2015-01-15 00:00:00

pages

527-34

issue

4

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(14)01594-1

journal_volume

33

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Understanding the reactogenicity of 4CMenB vaccine: Comparison of a novel and conventional method of assessing post-immunisation fever and correlation with pre-release in vitro pyrogen testing.

    abstract：BACKGROUND:Better understanding of vaccine reactogenicity is crucial given its potential impact upon vaccine safety and acceptance. Here we report a comparison between conventional and novel (continuous) methods of monitoring temperature and evaluate any association between reactogenicity and the monocyte activation te...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.10.023

    authors： Valente Pinto M,Davis K,Andrews N,Goldblatt D,Borrow R,Southern J,Nordgren IK,Vipond C,Plested E,Miller E,Snape MD

    更新日期：2020-11-17 00:00:00

  • Oral vaccination of broiler chickens against necrotic enteritis using a non-virulent NetB positive strain of Clostridium perfringens type A.

    abstract：:Necrotic enteritis (NE) is a severe disease of chickens and turkeys caused by some strains of Clostridium perfringens type A. The disease is well controlled by the use of in-feed antibiotic growth promoters (AGPs). However, due to worldwide public and regulatory pressure to reduce the use of AGPs inter alia, there is ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.030

    authors： Mishra N,Smyth JA

    更新日期：2017-12-14 00:00:00

  • Comparing pneumococcal conjugate vaccine schedules based on 3 and 2 primary doses: systematic review and meta-analysis.

    abstract：BACKGROUND:Pneumococcal conjugate vaccines (PCV) were first licensed for use with 3 primary doses in infancy and a booster dose. The evidence for the effects of different schedules was examined in this systematic review and meta-analysis. METHODS:We searched 12 databases and trial registers up to March 2010. We select...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vaccine.2011.07.042

    authors： Scott P,Rutjes AW,Bermetz L,Robert N,Scott S,Lourenço T,Egger M,Low N

    更新日期：2011-12-06 00:00:00

  • A/H1N1 pandemic influenza vaccination: A retrospective evaluation of adverse maternal, fetal and neonatal outcomes in a cohort of pregnant women in Italy.

    abstract：:Although concerns about safety of influenza vaccination during pregnancy have been raised in the past, vaccination of pregnant women was recommended in many countries during the 2009 A/H1N1 pandemic influenza. A retrospective cohort study was conducted to evaluate the risk of adverse maternal, fetal and neonatal outco...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.03.041

    authors： Fabiani M,Bella A,Rota MC,Clagnan E,Gallo T,D'Amato M,Pezzotti P,Ferrara L,Demicheli V,Martinelli D,Prato R,Rizzo C

    更新日期：2015-05-05 00:00:00

  • Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01.

    abstract：:Therapeutic immunization of HIV-1-infected individuals with or without anti-retroviral therapy is a new promising disease prevention. To induce a new cytotoxic T(CD8) lymphocyte (CTL) immunity during chronic HIV-1 infection 15 infrequently targeted but conserved HLA-supertype binding CTL epitopes from Gag, Pol, Nef, E...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.07.025

    authors： Fomsgaard A,Karlsson I,Gram G,Schou C,Tang S,Bang P,Kromann I,Andersen P,Andreasen LV

    更新日期：2011-09-16 00:00:00

  • Uptake of pandemic influenza (H1N1)-2009 vaccines in Brazil, 2010.

    abstract：:In 2010, the Brazilian Ministry of Health organized a mass vaccination campaign of selected priority groups in response to the 2009 H1N1 influenza pandemic. The campaign was conducted in six phases from March to July, 2010. Priority groups included healthcare professionals, indigenous persons, pregnant women, young ch...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2012.05.007

    authors： Domingues CM,de Oliveira WK,Brazilian Pandemic Influenza Vaccination Evaluation Team.

    更新日期：2012-07-06 00:00:00

  • No major outbreaks of pseudorabies virus in well-immunized sow herds.

    abstract：:In this study we quantified the transmission of pseudorabies virus (PRV) in well-immunized sow herds in The Netherlands. In three herds, sows were tested for antibodies to gE of PRV every time after they had been transported to another barn (survey A). In 99 other herds, sows were tested simultaneously once or twice y...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(96)00022-9

    authors： Van Nes A,Stegeman JA,De Jong MC,Loeffen WL,Kimman TG,Verheijden JH

    更新日期：1996-08-01 00:00:00

  • Effectiveness of rotavirus vaccines in preventing cases and hospitalizations due to rotavirus gastroenteritis in Navarre, Spain.

    abstract：:Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.071

    authors： Castilla J,Beristain X,Martínez-Artola V,Navascués A,García Cenoz M,Alvarez N,Polo I,Mazón A,Gil-Setas A,Barricarte A

    更新日期：2012-01-11 00:00:00

  • A therapeutic HIV-1 vaccine enhances anti-HIV-1 immune responses in patients under highly active antiretroviral therapy.

    abstract：BACKGROUND:HIV-1 specific cellular immunity plays an important role in controlling viral replication. In this first-in-human therapeutic vaccination study, a replication-defective HIV-1 vaccine (HIVAX) was tested in HIV-1 infected participants undergoing highly active antiretroviral therapy (HAART) to enhance anti-HIV ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2016.03.021

    authors： Tung FY,Tung JK,Pallikkuth S,Pahwa S,Fischl MA

    更新日期：2016-04-27 00:00:00

  • Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone.

    abstract：:The yield of influenza antigen production may significantly vary between vaccine strains; for example the A/California/07/09 (H1N1)-X179A vaccine virus, prepared during 2009 influenza pandemic, presented a low antigen yield in eggs compared to other seasonal H1N1 reassortants. In this study a bi-chimeric virus express...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.06.112

    authors： Medina J,Boukhebza H,De Saint Jean A,Sodoyer R,Legastelois I,Moste C

    更新日期：2015-08-20 00:00:00

  • Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers.

    abstract：:A hybrid protein [Met-Ala-(His)(6) OprF(190-342)-OprI(21-83)] consisting of the mature outer membrane protein I (OprI) and amino acids 190-342 of OprF of Pseudomonas aeruginosa was expressed in Escherichia coli and purified by Ni(2+) chelate-affinity chromatography. After several studies in healthy volunteers, as well...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0264-410x(00)00550-8

    authors： Larbig M,Mansouri E,Freihorst J,Tümmler B,Köhler G,Domdey H,Knapp B,Hungerer KD,Hundt E,Gabelsberger J,von Specht BU

    更新日期：2001-03-21 00:00:00

  • Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain.

    abstract：:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.036

    authors： Ly HJ,Nishiyama S,Lokugamage N,Smith JK,Zhang L,Perez D,Juelich TL,Freiberg AN,Ikegami T

    更新日期：2017-12-04 00:00:00

  • Efficacy of immunization against bovine mastitis using a Staphylococcus aureus avirulent mutant vaccine.

    abstract：:Bovine mastitis is responsible of major economic losses on dairy farms worldwide. In Argentine dairy herds, Staphylococcus aureus is the main causative agent of the disease. The ineffectiveness of some current practices to control S. aureus infections, often leads to a chronic and recurrent infection with persistent b...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.04.056

    authors： Pellegrino M,Giraudo J,Raspanti C,Odierno L,Bogni C

    更新日期：2010-06-17 00:00:00

  • Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis: Routes of immunization and TLR agonists critically impact vaccine's efficacy.

    abstract：:Mycobacterium tuberculosis (Mtb), the bacterial cause of tuberculosis, is a leading infectious agent worldwide. The development of a new vaccine against Mtb is essential to control global spread of tuberculosis, since the current vaccine BCG is not very effective and antibiotic resistance is a serious, burgeoning prob...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.08.075

    authors： Gupta N,Vedi S,Kunimoto DY,Agrawal B,Kumar R

    更新日期：2016-11-04 00:00:00

  • A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix(®) in subjects aged 11-17 years: an open, randomised, controlled trial.

    abstract：:The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2011.11.051

    authors： Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

    更新日期：2012-01-17 00:00:00

  • WHO Working Group on revision of the Manual of Laboratory Methods for Testing DTP Vaccines-Report of two meetings held on 20-21 July 2006 and 28-30 March 2007, Geneva, Switzerland.

    abstract：:This report reflects the discussion and conclusions of a WHO group of experts from National Regulatory Authorities (NRAs), National Control Laboratories (NCLs), vaccine industries and other relevant institutions involved in standardization and control of diphtheria, tetanus and pertussis vaccines (DTP), held on 20-21 ...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2008.02.013

    authors： Corbel MJ,Das RG,Lei D,Xing DK,Horiuchi Y,Dobbelaer R,WHO Working Group.

    更新日期：2008-04-07 00:00:00

  • Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning.

    abstract：:To identify Mycobacterium tuberculosis (Mtb) antigens as candidates for a subunit vaccine against tuberculosis (TB), we have employed a CD4+ T-cell expression screening method. Mtb-specific CD4+ T-cell lines from nine healthy PPD positive donors were stimulated with different antigenic substrates including autologous ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.10.056

    authors： Coler RN,Dillon DC,Skeiky YA,Kahn M,Orme IM,Lobet Y,Reed SG,Alderson MR

    更新日期：2009-01-07 00:00:00

  • Synthetic gonadotrophin-releasing hormone (GnRH) vaccines incorporating GnRH and synthetic T-helper epitopes.

    abstract：:A vaccine against the gonadotrophin-releasing hormone (GnRH) is being developed as an immunological method for treatment of prostatic hypertrophy, based on the observation that active immunization against GnRH leads to the production of anti-GnRH antibodies which results in the shrinkage of the prostate gland. We have...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90077-b

    authors： Sad S,Chauhan VS,Arunan K,Raghupathy R

    更新日期：1993-01-01 00:00:00

  • Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide.

    abstract：:In the present study the efficacy of recombinant plasmids DNA vaccine encoding VP2 gene of very virulent strain of infectious bursal disease virus (vvIBDV) isolated from Pakistan was investigated with or without coadministration of cytocine-phosphate-guanine oligodeoxynucleotide (CpG ODN) to protect the chickens again...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.03.016

    authors： Mahmood MS,Siddique M,Hussain I,Khan A,Mansoor MK

    更新日期：2006-05-29 00:00:00

  • Influenza vaccination in 22 developed countries: an update to 1995.

    abstract：:This study expands and updates through 1995 our earlier report on influenza vaccine use in 18 developed countries. Five of the six countries with high levels of vaccine use in 1992 (> or = 130 doses/1000 population) showed little change or slight declines over the subsequent 3 years. The exception was the United State...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00091-1

    authors： Fedson DS,Hirota Y,Shin HK,Cambillard PE,Kiely J,Ambrosch F,Hannoun C,Leese J,Sprenger MJ,Hampson AW,Bro-Jørgensen K,Ahlbom AM,Nøkleby H,Valle M,Olafsson O,Salmerón F,Cloetta J,Rebelo de Andrade H,Snacken R,Donatell

    更新日期：1997-10-01 00:00:00

  • Response, tolerance and ignorance following oral exposure to a single dietary protein antigen in Gallus domesticus.

    abstract：:The objective of this investigation was to analyze conditions leading to antibody responses against innocuous dietary protein antigens in the chick. The physical form of antigen was found to be important for immunization of mature chicks: bovine serum albumin (BSA) in solution was a powerful immunogen, while BSA powde...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00557-0

    authors： Klipper E,Sklan D,Friedman A

    更新日期：2001-04-06 00:00:00

  • Liposomes enhance the immunogenicity of reconstituted influenza virus A/PR/8 envelopes and the formation of protective antibody by influenza virus A/Sichuan/87 (H3N2) surface antigen.

    abstract：:Reconstituted influenza virus (A/PR/8 strain) envelopes (RIVE) and influenza virus (A/Sichuan/87 (H3N2) strain) surface antigens were entrapped in dehydration-rehydration vesicles (DRV liposomes) composed of egg phosphatidylcholine (PC) or distearoyl phosphatidylcholine (DSPC DRV) and equimolar (32 mumol) cholesterol....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90509-i

    authors： Gregoriadis G,Tan L,Ben-Ahmeida ET,Jennings R

    更新日期：1992-01-01 00:00:00

  • Using immunization delivery strategies to accelerate progress in Africa towards achieving the Millennium Development Goals.

    abstract：:Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.02.032

    authors： Clements CJ,Nshimirimanda D,Gasasira A

    更新日期：2008-04-07 00:00:00

  • Evaluation of hyaluronic acid-based combination adjuvant containing monophosphoryl lipid A and aluminum salt for hepatitis B vaccine.

    abstract：:Here, monophosphoryl lipid A (MPLA) and aluminum salt (Alum) were introduced into a hyaluronic acid (HA)-based combination vaccine adjuvant for hepatitis B vaccine (HBV). Although Alum is a well-known hepatitis B vaccine adjuvant that induces an enhanced humoral immune response, it cannot induce the cellular immune re...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.08.006

    authors： Moon SH,Shin EC,Noh YW,Lim YT

    更新日期：2015-09-11 00:00:00

  • Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines.

    abstract：:Persistence of antibodies 4 years after vaccination with measles, mumps and rubella (MMR) vaccine from three different manufacturers was compared in 475 children who received a single injection of vaccine when aged 12-18 months. Antibodies to measles and mumps were measured using a plaque reduction neutralisation assa...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(94)00086-3

    authors： Miller E,Hill A,Morgan-Capner P,Forsey T,Rush M

    更新日期：1995-06-01 00:00:00

  • Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination.

    abstract：:Although the currently used live attenuated measles vaccines are safe and effective, they are dependent on cold chain maintenance and are often ineffective in young infants due to interference by maternal antibody. Therefore, besides vector-based vaccines, different new generation non-replicating candidate measles vac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00048-8

    authors： Stittelaar KJ,de Swart RL,Vos HW,van Amerongen G,Sixt N,Wild TF,Osterhaus AD

    更新日期：2002-05-15 00:00:00

  • Inclusion of the value of herd immunity in economic evaluations of vaccines. A systematic review of methods used.

    abstract：OBJECTIVE:The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS:We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additi...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2017.10.024

    authors： Nymark LS,Sharma T,Miller A,Enemark U,Griffiths UK

    更新日期：2017-12-14 00:00:00

  • A DNA vaccine encoding ubiquitinated Rift Valley fever virus nucleoprotein provides consistent immunity and protects IFNAR(-/-) mice upon lethal virus challenge.

    abstract：:Current vaccine candidates against Rift Valley fever virus (RVFV) incorporate the viral structural glycoproteins as antigens, since triggering antibody responses against them usually correlates with protection. Here, we have focused solely on the nucleoprotein of RVFV as a potential target for vaccine development. Pre...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.04.043

    authors： Boshra H,Lorenzo G,Rodriguez F,Brun A

    更新日期：2011-06-15 00:00:00

  • Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons.

    abstract：:Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has been evaluating DNA plasmid based Pfs25 vaccine in mice and non-human primates. Previously, we established that ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.05.006

    authors： Kumar R,Nyakundi R,Kariuki T,Ozwara H,Nyamongo O,Mlambo G,Ellefsen B,Hannaman D,Kumar N

    更新日期：2013-06-28 00:00:00

  • Construction and murine immunogenicity of recombinant Bacille Calmette Guérin vaccines expressing the B subunit of Escherichia coli heat labile enterotoxin.

    abstract：:Three recombinant strains of Mycobacterium bovis Bacille Calmette Guerin (rBCG) were prepared in which the immunogenic B subunit of human Escherichia coli heat labile enterotoxin (LT-Bh) was expressed either as a cytoplasm protein, a cell wall associated lipoprotein or a secreted protein. Intraperitoneal immunisation ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00350-8

    authors： Hayward CM,O'Gaora P,Young DB,Griffin GE,Thole J,Hirst TR,Castello-Branco LR,Lewis DJ

    更新日期：1999-03-05 00:00:00