Abstract：
BACKGROUND:Lifetime protection against pertussis has been adopted as a goal of immunization programs in Canada. To anticipate adult coverage with a combined product containing tetanus (T) and diphtheria (d) toxoids and acellular pertussis (aP) vaccine as a booster dose, we conducted a survey of households in British Columbia, Canada. METHODS:In a random telephone survey involving 800 adults, 25 years of age and older, we assessed current behaviors related to adult Td immunization and beliefs regarding pertussis vaccine under various scenarios relevant to adult decision-making. RESULTS:Forty-five percent of participants reported having received tetanus vaccine within the previous 10 years; this rate was lowest amongst elderly persons 65 years of age or more (28%). On multi-variate analysis, being up-to-date with tetanus immunization was independently associated with belief that an adult should be immunized against tetanus and perception that tetanus is life-threatening and inversely associated with being elderly. At baseline, 59% of respondents indicated willingness to receive pertussis immunization if provided free; this increased to 76% following sequential information about communicability and severity of pertussis illness and safety, efficacy and convenience of vaccine and up to 87% if accompanied by physician or nurse recommendation. Sixty-three percent of adults indicated they would receive the vaccine if required to pay $40.00 (Cdn) for it. CONCLUSIONS:Personal risk perception, public funding and physician recommendation are important to adults when considering tetanus and pertussis immunization. These factors may be relevant as immunization programs are expanded to include more adults generally.
journal_name
Vaccinejournal_title
Vaccineauthors
Skowronski DM,Pielak K,Remple VP,Halperin BA,Patrick DM,Naus M,McIntyre Cdoi
10.1016/j.vaccine.2004.05.033subject
Has Abstractpub_date
2004-12-02 00:00:00pages
353-61issue
3eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00447-5journal_volume
23pub_type
杂志文章相关文献
VACCINE文献大全abstract：AIM:To establish whether universal vaccination of infants with the pneumococcal conjugate vaccine is likely to be cost-effective from the perspective of the health care provider (NHS). METHOD:Two hypothetical cohorts--one vaccinated and one unvaccinated--were followed over their lifetime, and the expected net costs an...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.05.003
更新日期：2004-10-22 00:00:00
abstract：:In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.07.057
更新日期：2012-09-14 00:00:00
abstract：INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.05.044
更新日期：2020-07-22 00:00:00
abstract：:A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.05.028
更新日期：2008-07-29 00:00:00
abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.02.074
更新日期：2018-04-12 00:00:00
abstract：BACKGROUND:We evaluated the safety and immunogenicity of liquid and lyophilized formulations of an investigational trivalent group B streptococcus (GBS) vaccine in non-pregnant women and assessed the formulations' equivalence in terms of serotype-specific immune response. METHODS:This phase II, randomized, comparative...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.02.085
更新日期：2020-04-03 00:00:00
abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00450-4
更新日期：2002-12-13 00:00:00
abstract：:Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.04.055
更新日期：2018-05-31 00:00:00
abstract：:The tetanus and diphtheria vaccination programme in Finland has been running for 50 years. After primary doses, tetanus boosters have been offered to men in military service and decennial boosters recommended for all through the adult life. For 30 years a diphtheria booster was only offered to men in the military serv...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.06.080
更新日期：2009-08-27 00:00:00
abstract：:Plasmodium vivax is the second most common agent of human malaria. Although infection is rarely fatal, it nonetheless imposes a significant burden of illness in endemic areas. A successful vaccine against P. vivax will likely need to induce immune responses against both pre-erythrocytic and erythrocytic stage forms of...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00146-2
更新日期：1999-08-06 00:00:00
abstract：:Surface modified poly-ɛ-caprolactone microspheres as an antigen carrier was explored in a fish model. Outer membrane vesicles of Edwardsiella tarda adsorbed on to surface modified poly-ɛ-caprolactone microspheres with chitosan and alginate induces both innate and adaptive immune responses which persist up to 63 days o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.05.028
更新日期：2012-07-27 00:00:00
abstract：:Dendritic cells (DCs) have been identified as the most effective antigen-presenting cell (APC), much attention has been directed toward the use of DCs in vaccine strategies for the treatment of cancer or chronic virus infection. B7-H1 (PD-L1) is a ligand for programmed cell death-1 (PD-1) and does not bind to other CD...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.11.076
更新日期：2012-01-17 00:00:00
abstract：:OprI is an outer membrane lipoprotein from Pseudomonas aeruginosa, and when fused to a recombinant antigen, will exert adjuvant properties by engaging Toll-like receptor 2, leading to dendritic cell activation. Previous studies have shown that the Neospora caninum (Nc) antigens NcPDI, NcROP2 and NcROP40 are implicated...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.11.060
更新日期：2019-01-14 00:00:00
abstract：:The development of potent adjuvants, conditioning innate and adaptative immunity, particularly CTL responses, has become currently a hot point in the rational design of vaccines for cancer immunotherapy. We have described a new approach, in which gangliosides are incorporated into vesicles from Neisseria meningitidis ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.08.111
更新日期：2006-03-24 00:00:00
abstract：:The United States Advisory Committee on Immunization Practices (ACIP) is a federal advisory committee that develops written recommendations for use of vaccines licensed by the Food and Drug Administration (FDA) for the U.S. civilian population. Vaccine development and disease outbreaks contributed to the need for a sy...
journal_title：Vaccine
pub_type： 历史文章,杂志文章
doi：10.1016/j.vaccine.2014.09.043
更新日期：2015-01-09 00:00:00
abstract：:The ability to elicit humoral and cell-mediated immune (CMI) responses from DNA immunization by combinational use of codon optimization and C3d component of complement was evaluated in this study. DNA vaccines that express either the wild type or the codon optimized gp120 gene coding for the envelope (Env) glycoprotei...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.09.054
更新日期：2004-04-16 00:00:00
abstract：:A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.04.071
更新日期：2008-07-04 00:00:00
abstract：:A gene associated with lipopolysaccharide (LPS) transport was cloned from a local clinical Vibrio cholerae O1 strain of the Ogawa serotype by using the Lactococcus lactis nisin-controlled expression (NICE) system. The V. cholerae wzm gene, which codes for an integral membrane transporter protein, was expressed and tar...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.02.012
更新日期：2012-05-02 00:00:00
abstract：:The avian coronavirus infectious bronchitis virus (IBV) S1 subunit of the spike (S) glycoprotein mediates viral attachment to host cells and the S2 subunit is responsible for membrane fusion. Using IBV Arkansas-type (Ark) S protein histochemistry, we show that extension of S1 with the S2 ectodomain improves binding to...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.09.013
更新日期：2017-10-13 00:00:00
abstract：:Optimal protection against malaria may require induction of high levels of protective antibody and CD8(+) and CD4(+) T cell responses. In humans, malaria DNA vaccines elicit CD8(+) cytotoxic T cells (CTL) and IFNgamma responses as measured by short-term (ex vivo) ELISPOT assays, and recombinant proteins elicit antibod...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/j.vaccine.2004.01.031
更新日期：2004-04-16 00:00:00
abstract：INTRODUCTION:Rotavirus infection mainly affects children under 5 years of age and causes 453,000 deaths annually throughout the world. Several countries in Latin America have introduced the rotavirus vaccine and the majority have epidemiological data to measure impact following vaccine introduction. OBJECTIVE:To asses...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.05.065
更新日期：2013-07-02 00:00:00
abstract：:Using mass spectrometry and immunological approaches, a heat shock protein 70 associated with lymphatic filariasis (LF) has been identified from a bovine filarial parasite Setaria cervi. A heat shock protein was detected in different life stages of S. cervi when exposed to an elevated temperature of 44 degrees C. A co...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.06.044
更新日期：2010-02-03 00:00:00
abstract：:Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly interv...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00442-9
更新日期：2000-03-17 00:00:00
abstract：:Although studies have suggested that a patient's perceived cost-benefit of a medical intervention could affect his or her utilization of the intervention, the economic value of influenza vaccine from the patient's perspective remains unclear. Therefore, we developed a stochastic decision analytic computer model repres...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.12.078
更新日期：2011-03-03 00:00:00
abstract：BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.12.026
更新日期：2013-02-04 00:00:00
abstract：:Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.09.122
更新日期：2011-11-21 00:00:00
abstract：:Enterotoxigenic Escherichia coli (ETEC), which produces heat labile toxin (LT) and/or heat stable toxin (ST), is considered to be the most common known cause of travellers' diarrhoea (TD). Owing to the antigenic similarity between cholera toxin and LT, immunization with inactivated oral B-subunit/whole-cell cholera va...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.05.022
更新日期：2005-10-17 00:00:00
abstract：:Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.080
更新日期：2015-02-11 00:00:00
abstract：:Recently avian influenza A viruses of the H5N1 subtype were shown to infect humans in the Hong Kong area, resulting in the death of six people. Although these viruses did not efficiently spread amongst humans, these events illustrated that influenza viruses of subtypes not previously detected in humans could be at the...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00390-9
更新日期：1999-03-17 00:00:00
abstract：:Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations tha...
journal_title：Vaccine
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.vaccine.2012.09.034
更新日期：2012-11-26 00:00:00
