Immunization with a cocktail of antigens fused with OprI reduces Neospora caninum vertical transmission and postnatal mortality in mice.

Abstract:

:OprI is an outer membrane lipoprotein from Pseudomonas aeruginosa, and when fused to a recombinant antigen, will exert adjuvant properties by engaging Toll-like receptor 2, leading to dendritic cell activation. Previous studies have shown that the Neospora caninum (Nc) antigens NcPDI, NcROP2 and NcROP40 are implicated in host cell interactions and are promising vaccine candidates. In two independent experiments, the efficacy of a polyvalent vaccine formulation composed of OprI-NcPDI, OprI-NcROP2 and OprI-NcROP40 (collectively named O-Ags) was assessed in non-pregnant and pregnant Balb/c mouse models challenged with tachyzoites of the high-virulence isolate Nc-Spain7. Parameters that were investigated were clinical signs, fertility, parasite burden in adult mice, humoral and cellular immune responses at different time-points prior to and after challenge infection, vertical transmission and post-natal survival of offspring mice, all to explore potential correlations with efficacy. Vaccination of mice with O-Ags induced a mixed Th1/Th2 immune response in adult mice and led to significantly increased protection against cerebral infection. Vaccination with O-Ags also resulted in reduced vertical transmission, and postnatal disease in offspring was significantly inhibited at a rate not observed in mice infected with a high-virulence isolate to date. However, O-Ags mixed with TLR ligands targeting TLR3 and TLR7, which are known to induce clear Th1-biased responses, or vaccination with OprI fused to the non-N. caninum antigen ovalbumin (OprI-OVA) did not confer protection.

journal_name

Vaccine

journal_title

Vaccine

authors

Aguado-Martínez A,Basto AP,Tanaka S,Ryser LT,Nunes TP,Ortega-Mora LM,Arranz-Solís D,Leitão A,Hemphill A

doi

10.1016/j.vaccine.2018.11.060

subject

Has Abstract

pub_date

2019-01-14 00:00:00

pages

473-483

issue

3

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(18)31585-8

journal_volume

37

pub_type

杂志文章

相关文献

VACCINE文献大全
  • A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.

    abstract::In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2009.10.152

    authors: Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

    更新日期:2010-04-09 00:00:00

  • Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations.

    abstract::Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.09.122

    authors: Freed DC,Towne VM,Casimiro DR,Zhao Q,Fu TM

    更新日期:2011-11-21 00:00:00

  • Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica.

    abstract::Cattle produce specific serum antibody mainly of the IgG1 isotype in response to infection with the liver fluke, Fasciola hepatica. In these animals a positive correlation between fluke-specific serum IgG1 levels and fluke-burden in non-immunized infected animals was observed. In contrast, immunization of cattle with ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(97)00289-2

    authors: Mulcahy G,O'Connor F,McGonigle S,Dowd A,Clery DG,Andrews SJ,Dalton JP

    更新日期:1998-05-01 00:00:00

  • Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres.

    abstract::The development of a safe and effective vaccine against enterotoxigenic Escherichia coli (ETEC) would be useful for travellers and for young children in endemic areas. A feasibility study of an enteral ETEC vaccine prototype consisting of colonization factor antigen II (CFA/II), containing two component antigens CS1 a...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0264-410x(94)80038-2

    authors: Tacket CO,Reid RH,Boedeker EC,Losonsky G,Nataro JP,Bhagat H,Edelman R

    更新日期:1994-11-01 00:00:00

  • Tetanus immunity among Italians born after the introduction of mandatory vaccination of children.

    abstract::In Italy systematic mandatory tetanus immunization of children started in 1968. In a national sample of 241 young males born after 1968 the prevalence of non-immune subjects was 11.2% (5.5% in the North-Centre, 15.9% in the South-Islands; p < 0.02). Comparing these data with the corresponding figure obtained in a prev...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(93)90381-7

    authors: D'Amelio R,Stroffolini T,Wirz M,Biselli R,Matricardi PM,Gentili G,Collotti C,Pasquini P

    更新日期:1993-01-01 00:00:00

  • Evaluation of potentially achievable vaccination coverage with simultaneous administration of vaccines among children in the United States.

    abstract:BACKGROUND:Routine administration of all age-appropriate doses of vaccines during the same visit is recommended for children by the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). METHODS:Evaluate the potentially achievable vaccination coverage for ≥4 doses of di...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.04.097

    authors: Zhao Z,Smith PJ,Hill HA

    更新日期:2016-06-08 00:00:00

  • Identification of Setaria cervi heat shock protein 70 by mass spectrometry and its evaluation as diagnostic marker for lymphatic filariasis.

    abstract::Using mass spectrometry and immunological approaches, a heat shock protein 70 associated with lymphatic filariasis (LF) has been identified from a bovine filarial parasite Setaria cervi. A heat shock protein was detected in different life stages of S. cervi when exposed to an elevated temperature of 44 degrees C. A co...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.06.044

    authors: Srivastava S,Srikanth E,Liebau E,Rathaur S

    更新日期:2010-02-03 00:00:00

  • Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine.

    abstract::Immunization with amyloid-beta (Abeta) peptide reduces amyloid load in animal studies and in humans; however clinical trials resulted in the development of a pro-inflammatory cellular response to Abeta. Apoptosis has been employed to stimulate humoral and Th2-biased cellular immune responses. Thus, we sought to invest...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.12.044

    authors: DaSilva KA,Brown ME,McLaurin J

    更新日期:2009-02-25 00:00:00

  • A recombinant fowl adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus.

    abstract::The spike peplomer S1 subunit sequence from avian infectious bronchitis virus (IBV) Vic S strain was expressed in a plasmid under the control of the fowl adenovirus (FAV) major late promoter (MLP). Two recombinants were constructed in FAV serotype 8 (FAV 8) by inserting the expression cassette between the SnaBI and Xb...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(03)00227-5

    authors: Johnson MA,Pooley C,Ignjatovic J,Tyack SG

    更新日期:2003-06-20 00:00:00

  • Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model.

    abstract::Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strat...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.02.071

    authors: Shen X,Söderholm J,Lin F,Kobinger G,Bello A,Gregg DA,Broderick KE,Sardesai NY

    更新日期:2012-11-06 00:00:00

  • Estimating the vaccine-preventable burden of hospitalized pneumonia among young Mozambican children.

    abstract::Polysaccharide-protein conjugate vaccines against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae have proven efficacy against radiologically confirmed pneumonia. Measurement of pneumonia incidence provides a platform to estimate of the vaccine-preventable burden. Over 24 months, we conducted surveill...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.03.060

    authors: Roca A,Sigaúque B,Quintó L,Morais L,Berenguera A,Corachan M,Ribó JL,Naniche D,Bassat Q,Sacoor Ch,Nhalungo D,Macete E,Schuchat A,Soriano-Gabarró M,Flannery B,Alonso PL

    更新日期:2010-07-05 00:00:00

  • Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy).

    abstract::The aim of the study was to investigate factors involved in vaccination acceptance among healthcare workers (HCWs) and adverse reactions rates associated with pandemic influenza vaccination. The study was carried out in the major teaching hospital of Sicily from November 2009 to February 2010 on 2267 HCWs. A total of ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.12.041

    authors: Amodio E,Anastasi G,Marsala MG,Torregrossa MV,Romano N,Firenze A

    更新日期:2011-02-04 00:00:00

  • Effectiveness of mouse brain-derived inactivated Japanese encephalitis vaccine in Thai National Immunization Program: a case-control study.

    abstract::Mouse brain-derived, purified inactivated Japanese encephalitis vaccine (MB JEV) has been locally produced and introduced into Thai National Immunization Program (NIP) since 1990. However, MB JEV effectiveness has been concerned, since 30-40% of JE cases received JE vaccines were recently reported in two descriptive s...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.10.083

    authors: Muangchana C,Henprasertthae N,Nurach K,Theppang K,Yoocharoen P,Varinsathien P,Techathawat S,Sanohsieng S,Anantapreecha S

    更新日期:2012-01-05 00:00:00

  • Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.

    abstract::We investigated the therapeutic effects of romurtide, a synthetic muramyl dipeptide derivative, on experimental thrombocytopenia induced by carboplatin in cynomolgus monkeys. A prolonged thrombocytopenia due to a severe myelosuppression was induced by carboplatin. Romurtide given subcutaneously elevated significantly ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(96)00064-3

    authors: Namba K,Nitanai H,Otani T,Azuma I

    更新日期:1996-10-01 00:00:00

  • CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes.

    abstract::Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several antigens, in addition to the polysaccharide capsule, have been implicated in both the virulence and protective immunity against Streptococcus pneumoniae; one of ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.12.020

    authors: Singh R,Singh S,Briles DE,Taub DD,Hollingshead SK,Lillard JW Jr

    更新日期:2012-02-01 00:00:00

  • Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA.

    abstract::The RNA N-glycosidase ribosome inactivating proteins (RIPs) constitute a ubiquitous family of plant- and bacterium-derived toxins that includes the category B select agents ricin, abrin and shiga toxin. While these toxins are potent inducers of intestinal epithelial cell death and inflammation, very little is known ab...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.11.030

    authors: Neal LM,McCarthy EA,Morris CR,Mantis NJ

    更新日期:2011-01-17 00:00:00

  • Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

    abstract::Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.06.040

    authors: Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

    更新日期:2009-08-06 00:00:00

  • Impact of postpartum information about pertussis booster to parents in a university maternity hospital.

    abstract::Parent-to-infant transmission of pertussis remains an issue in France. Although adult booster vaccination was introduced in 2004 as part of a cocooning strategy targeted primarily to parents of young infants, vaccination coverage in this population has remained low. The aim of this study was to evaluate the impact on ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.06.071

    authors: Leboucher B,Sentilhes L,Abbou F,Henry E,Grimprel E,Descamps P

    更新日期:2012-08-10 00:00:00

  • New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles.

    abstract::One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the quality of polyclonal anti-E1E2 antibody responses in immunized mice and...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.10.045

    authors: Kachko A,Kochneva G,Sivolobova G,Grazhdantseva A,Lupan T,Zubkova I,Wells F,Merchlinsky M,Williams O,Watanabe H,Ivanova A,Shvalov A,Loktev V,Netesov S,Major ME

    更新日期:2011-12-09 00:00:00

  • Protection induced in mice against a lethal orthopox virus by the Lister strain of vaccinia virus and modified vaccinia virus Ankara (MVA).

    abstract::The Lister (Elstree) strain of vaccinia virus, used in Israel for vaccination against smallpox, was studied in tissue cultures and in a mouse model. The virus failed to reach the brain of the mice when inoculated intranasally at a dose of 500,000 plaque forming units, but was lethal for 50% of them, when injected intr...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.02.012

    authors: Abdalrhman I,Gurt I,Katz E

    更新日期:2006-05-08 00:00:00

  • Hepatitis A virus seroprevalence by age and world region, 1990 and 2005.

    abstract:OBJECTIVE:To estimate current age-specific rates of immunity to hepatitis A virus (HAV) in world regions by conducting a systematic review and meta-analysis of published data. The estimation of the global burden of hepatitis A and policies for public health control are dependent on an understanding of the changing epid...

    journal_title:Vaccine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.vaccine.2010.08.037

    authors: Jacobsen KH,Wiersma ST

    更新日期:2010-09-24 00:00:00

  • Application of the Geographic Information System (GIS) in immunisation service delivery; its use in the 2017/2018 measles vaccination campaign in Nigeria.

    abstract:BACKGROUND:As global effort is made towards measles elimination, the use of innovative technology to enhance planning for the campaign has become critical. GIS technology has been applied to track polio vaccination activities in Nigeria with encouraging outcomes. Despite numerous measles vaccination campaigns after the...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2021.01.021

    authors: Oteri J,Idi Hussaini M,Bawa S,Ibizugbe S,Lambo K,Mogekwu F,Wiwa O,Seaman V,Kolbe-Booysen O,Braka F,Nsubuga P,Shuaib F

    更新日期:2021-01-18 00:00:00

  • Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan.

    abstract::During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus ...

    journal_title:Vaccine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.vaccine.2014.11.015

    authors: Shimizu H

    更新日期:2016-04-07 00:00:00

  • Plasmodium falciparum circumsporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria of Kenya.

    abstract::It has been hypothesized that antibody induced by Plasmodium falciparum circumsporozoite protein vaccine would be effective against endemic human malaria. In a malaria endemic region of Kenya, 76 volunteers, in 38 pairs sleeping adjacently, were immunized with subunit circumsporozoite protein Asn-Ala-Asn-Pro tetrapept...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0264-410x(95)00221-l

    authors: Sherwood JA,Copeland RS,Taylor KA,Abok K,Oloo AJ,Were JB,Strickland GT,Gordon DM,Ballou WR,Bales JD Jr,Wirtz RA,Wittes J,Gross M,Que JU,Cryz SJ,Oster CN,Roberts CR,Sadoff JC

    更新日期:1996-06-01 00:00:00

  • A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants.

    abstract:BACKGROUND:Neisseria meningitidis serogroup B (MnB) is a major cause of invasive meningococcal disease in infants. A conserved, surface-exposed lipoprotein, LP2086 (a factor H-binding protein [fHBP]), is a promising MnB vaccine target. A bivalent, recombinant vaccine targeting the fHBP (rLP2086) of MnB was developed. ...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2014.07.049

    authors: Martinon-Torres F,Gimenez-Sanchez F,Bernaola-Iturbe E,Diez-Domingo J,Jiang Q,Perez JL

    更新日期:2014-09-08 00:00:00

  • Measurement of Clostridium perfringens beta-toxin production by surface plasmon resonance immunoassay.

    abstract::A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(97)00282-x

    authors: Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

    更新日期:1998-05-01 00:00:00

  • Vaccination for control of Salmonella in poultry.

    abstract::Salmonella spp. are facultative intracellular pathogens causing localised or systemic infections, in addition to a chronic asymptomatic carrier state. They are of worldwide economic and public health significance. In poultry, which represent important sources of cheap protein throughout the world, fowl typhoid and pul...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/s0264-410x(99)00060-2

    authors: Zhang-Barber L,Turner AK,Barrow PA

    更新日期:1999-06-04 00:00:00

  • Infectious bursal disease virus rescued efficiently with 3' authentic RNA sequence induces humoral immunity without bursal atrophy.

    abstract::A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.11.040

    authors: Mosley YY,Wu CC,Lin TL

    更新日期:2013-01-11 00:00:00

  • Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus.

    abstract::A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). In this study, CPMV-PARVO1 was inactivated by UV tre...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(01)00083-4

    authors: Langeveld JP,Brennan FR,Martínez-Torrecuadrada JL,Jones TD,Boshuizen RS,Vela C,Casal JI,Kamstrup S,Dalsgaard K,Meloen RH,Bendig MM,Hamilton WD

    更新日期:2001-06-14 00:00:00

  • High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine.

    abstract:PURPOSE:We conducted a cancer vaccine clinical trial with MAGE-A4 protein. Safety, clinical response, and antigen-specific immune responses were analyzed and the prognostic factors by vaccination were investigated. EXPERIMENTAL DESIGN:Twenty patients with advanced esophageal, stomach or lung cancer were administered M...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.09.002

    authors: Saito T,Wada H,Yamasaki M,Miyata H,Nishikawa H,Sato E,Kageyama S,Shiku H,Mori M,Doki Y

    更新日期:2014-10-14 00:00:00