Very small size proteoliposomes derived from Neisseria meningitidis: An effective adjuvant for generation of CTL responses to peptide and protein antigens.

abstract：:The whole cell vaccine (WCV) of Bordetella pertussis is protective in the intracerebral (i.c.) mouse protection assay. We found a correlation between the i.c. mouse protection assay potency and the presence of the virulence-associated outer membrane proteins (OMPs) in outer membrane complexes (OMC). The virulence-asso...

journal_title：Vaccine

authors： Hamstra HJ,Kuipers B,Schijf-Evers D,Loggen HG,Poolman JT

更新日期：1995-01-01 00:00:00

abstract：:This study aimed to evaluate the durability of the immunogenicity of MVA85A beyond infancy. Participants in an immunogenicity study of MVA85A administered at age of 4 months had additional evaluation 14 months after initial vaccination for IFN-γ ELISPOT responses to Ag85A peptide and ESAT6/CFP-10 and tuberculin skin t...

journal_title：Vaccine

authors： Odutola AA,Owolabi OA,Owiafe PK,McShane H,Ota MO

更新日期：2012-08-17 00:00:00

abstract：:We aim to develop a method that confers rapid protection against foot-and-mouth disease (FMD) by passive immunization with recombinant llama single-domain antibody fragments (VHHs). Previously constructed genetic fusions of two VHHs (VHH2s) that either neutralizes FMDV or binds to porcine immunoglobulin to increase th...

journal_title：Vaccine

authors： Harmsen MM,Fijten HP,Engel B,Dekker A,Eblé PL

更新日期：2009-03-18 00:00:00

abstract：:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine can...

journal_title：Vaccine

authors： Oberg AL,McKinney BA,Schaid DJ,Pankratz VS,Kennedy RB,Poland GA

更新日期：2015-09-29 00:00:00

abstract：:The efficacy of antibody immunity against Streptococcus pneumoniae stems from the ability of opsonic, serotype (ST)-specific antibodies to pneumococcal capsular polysaccharide (PPS) to facilitate killing of the homologous ST by host phagocytes. However, PPS-specific antibodies have been identified that are protective ...

journal_title：Vaccine

authors： Fabrizio K,Manix C,Tian H,van Rooijen N,Pirofski LA

更新日期：2010-11-03 00:00:00

abstract：:Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and in animals. Spores are also employed in a veterinary vaccine against anthrax. Despite this long lasting and extensive use, the specific contribution of spores to the beneficial effects of probiotics an...

journal_title：Vaccine

authors： Oggioni MR,Ciabattini A,Cuppone AM,Pozzi G

更新日期：2003-06-01 00:00:00

abstract：:In 2013, avian H7N9 influenza viruses were detected infecting people in China resulting in high mortality. Influenza H7 vaccines that provide cross-protection against these new viruses are needed until specific H7N9 vaccines are ready to market. In this study, an available H7N3 cold-adapted, temperature sensitive, liv...

journal_title：Vaccine

authors： Carter DM,Bloom CE,Kirchenbaum GA,Tsvetnitsky V,Isakova-Sivak I,Rudenko L,Ross TM

更新日期：2015-01-01 00:00:00

abstract：:By the strategy "reverse vaccinology" a number of new antigens have been identified in Neisseria meningitidis, which are potential candidates for a highly needed broad-spectrum meningococcal vaccine. In the present study we examined the prevalence, sequence constancies and variations of the genes encoding three of the...

journal_title：Vaccine

authors： Jacobsson S,Thulin S,Mölling P,Unemo M,Comanducci M,Rappuoli R,Olcén P

更新日期：2006-03-15 00:00:00

abstract：:The prevalence of hepatitis B virus (HBV) infection and its sequelae vary widely in the different populations living in the Asian-Pacific region. Horizontal transmission plays an important role in the spread of the disease; in East Asia, however, maternal transmission is particularly significant since a high portion o...

journal_title：Vaccine

authors： Sung JL

更新日期：1990-03-01 00:00:00

abstract：:Dengue virus (DENV) is the causal agent of severe disease and, in some cases, mortality in humans, but no licensed vaccines against dengue are available. An effective vaccine against dengue requires long-term humoral and cellular immune responses. Several viral proteins have been the subjects of intense research, espe...

journal_title：Vaccine

authors： Coconi-Linares N,Ortega-Dávila E,López-González M,García-Machorro J,García-Cordero J,Steinman RM,Cedillo-Barrón L,Gómez-Lim MA

更新日期：2013-05-01 00:00:00

abstract：:Shigellosis, a major cause of diarrhea worldwide, exhibits high morbidity and mortality in children. Specificity of Shigella immunity is determined by the structure of the main protective O-antigen polysaccharide component incorporated into the lipopolysaccharide (LPS) molecule. Endotoxicity, however, precludes LPS cl...

journal_title：Vaccine

authors： Ledov VA,Golovina ME,Markina AA,Knirel YA,L'vov VL,Kovalchuk AL,Aparin PG

更新日期：2019-02-14 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC), which produces heat labile toxin (LT) and/or heat stable toxin (ST), is considered to be the most common known cause of travellers' diarrhoea (TD). Owing to the antigenic similarity between cholera toxin and LT, immunization with inactivated oral B-subunit/whole-cell cholera va...

journal_title：Vaccine

authors： Leyten EM,Soonawala D,Schultsz C,Herzog C,Ligthelm RJ,Wijnands S,Visser LG

更新日期：2005-10-17 00:00:00

abstract：OBJECTIVE:Rotavirus is the most common cause of severe diarrhea in children. Two rotavirus vaccines (RotaTeq and Rotarix) have been licensed in Taiwan. We have investigated whether routine infant immunization with either vaccine could be cost-effective in Taiwan. METHODS:We modeled specific disease outcomes including ...

journal_title：Vaccine

authors： Wu CL,Yang YC,Huang LM,Chen KT

更新日期：2009-03-04 00:00:00

abstract：:A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborns, we co-administered pCSP with a plasmid encoding granulocyte-macroph...

journal_title：Vaccine

authors： Ishii KJ,Weiss WR,Klinman DM

更新日期：1999-11-12 00:00:00

abstract：:This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein's structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for their stabilizing ...

journal_title：Vaccine

authors： Toprani VM,Sahni N,Hickey JM,Robertson GA,Middaugh CR,Joshi SB,Volkin DB

更新日期：2017-10-04 00:00:00

abstract：:Equine influenza is a contagious diseases caused by equine influenza viruses which belong to the orthomyxovirus family. Outbreaks of equine influenza cause severe economic loses to the horse industry and consequently competition horses are required to be regularly vaccinated against equine influenza. Currently availab...

journal_title：Vaccine

authors： Heldens JG,Pouwels HG,Derks CG,Van de Zande SM,Hoeijmakers MJ

更新日期：2009-09-04 00:00:00

abstract：:In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...

journal_title：Vaccine

authors： Uddowla S,Freytag LC,Clements JD

更新日期：2007-11-19 00:00:00

abstract：:Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay an...

journal_title：Vaccine

authors： Marlovits S,Stocker R,Efstratiou A,Broughton K,Kaider A,Vécsei V,Wiedermann G,Kollaritsch H

更新日期：2000-12-08 00:00:00

abstract：:Newcastle disease virus (NDV), an avian virus, is being evaluated for the development of vectored human vaccines against emerging pathogens. Previous studies of NDV-vectored vaccines in a mouse model suggested their potency after delivery by injection or by the intranasal route. We compared the efficacy of various rou...

journal_title：Vaccine

authors： DiNapoli JM,Ward JM,Cheng L,Yang L,Elankumaran S,Murphy BR,Samal SK,Collins PL,Bukreyev A

更新日期：2009-03-04 00:00:00

abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

journal_title：Vaccine

authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

更新日期：2019-11-08 00:00:00

abstract：:Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...

journal_title：Vaccine

authors： Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

更新日期：2007-01-05 00:00:00

abstract：:Presence of maternally-derived antibodies at time of immunization is known to often interfere with active infant immunization, although with variable degrees of clinical significance. In order to progressively decipher the rules that form the basis for these inhibitory effects on infant vaccine responses, two antigens...

journal_title：Vaccine

authors： Siegrist CA,Córdova M,Brandt C,Barrios C,Berney M,Tougne C,Kovarik J,Lambert PH

更新日期：1998-08-01 00:00:00

abstract：:The chloroplast genetic engineering offers a number of unique advantages including high level of transgene expression, multi-gene expression in single transformation event and transgene containment due to maternal inheritance. Hyper-expression of vaccine antigens or therapeutic proteins in transgenic chloroplasts (lea...

journal_title：Vaccine

authors： Daniell H,Chebolu S,Kumar S,Singleton M,Falconer R

更新日期：2005-03-07 00:00:00

abstract：:Proteins isolated from the midgut of Glossina pallidipes were used to immunize rabbits and their efficacy as vaccine candidate(s) against the fly, and their potential to block transmission of Trypanosoma brucei rhodesiense assessed. Two fractions, detergent (DET) and aqueous (AQ) fractions were separated using a non-i...

journal_title：Vaccine

authors： Kinyua JK,Nguu EK,Mulaa F,Ndung'u JM

更新日期：2005-05-31 00:00:00

abstract：:This cross-sectional study aimed to assess pertussis seroprevalence among healthy healthcare workers (HCW) of the Children's Hospital of Tunis, Tunisia. During the study period, 236 blood samples were obtained to determine HCW exposure to pertussis. Concentrations of immunoglobulin G (IgG) to pertussis toxin (PT) were...

journal_title：Vaccine

authors： Ben Fraj I,Smaoui H,Zghal M,Sassi O,Guiso N,Kechrid A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:US-bound refugees undergo required health assessments overseas to identify and treat communicable diseases of public health significance-such as pulmonary tuberculosis-before migration. Immunizations are not required, leaving refugees at risk for vaccine-preventable diseases. In response, the US Centers for ...

journal_title：Vaccine

authors： Mitchell T,Dalal W,Klosovsky A,Yen C,Phares C,Burkhardt M,Amin F,Froes I,Hamadeh A,Lynn SA,Quintanilla J,Doney AC,Cetron M,Weinberg M

更新日期：2021-01-03 00:00:00

abstract：:Prevention of lifestyle-related diseases and promotion of physical and mental well-being in adolescents require an understanding of how life situations place adolescents at risk. The most important risk factors for hepatitis B virus (HBV) infection are sexual activity with more than one partner and injecting drug use....

journal_title：Vaccine

authors： Meheus A

更新日期：2000-02-18 00:00:00

abstract：:Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, alt...

journal_title：Vaccine

authors： Bolton DL,Song K,Tomaras GD,Rao S,Roederer M

更新日期：2017-01-23 00:00:00

abstract：:Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differen...

journal_title：Vaccine

authors： Van de Velde N,Brisson M,Boily MC

更新日期：2010-07-26 00:00:00

abstract：:In 1982, a two-dose programme of vaccination against measles, mumps and rubella (MMR) at the ages of 18 months and 12 years was introduced in Sweden. In 1992-3, the first group of children vaccinated at 18 months reached the age of 12, i.e. the time for a second dose. In connection with this 12-year vaccination, 376 c...

journal_title：Vaccine

authors： Böttiger M

更新日期：1995-12-01 00:00:00