当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Construction and evaluation of an expression vector allowing the stable expression of foreign antigens in a Salmonella typhimurium vaccine strain.

Construction and evaluation of an expression vector allowing the stable expression of foreign antigens in a Salmonella typhimurium vaccine strain.

Abstract：

:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of expression of the heterologous antigen. To solve this problem an expression vector was developed with a strong promoter located on a DNA fragment which is inverted at random. Antigen is only expressed in one particular orientation of the promoter. Thus a bacterial population harbouring the plasmid will consist of a subpopulation which does not produce heterologous antigen, and is therefore not affected in growth, persistence and dissemination within the host. Further, this non-producing population will continuously segregate antigen-producing bacteria. To evaluate the system, CtxB was used as a model antigen. Analysis of the plasmid DNA isolated from Salmonella revealed a selection against the promoter orientation that directs transcription of the ctxB gene. In spite of this, the vector was stably maintained in vivo and induced CtxB-specific IgA and IgG in mice. These results indicate that this kind of expression vector may offer a solution to the problem of unstable expression of foreign antigens in live bacterial vaccine strains.

journal_name

Vaccine

journal_title

Vaccine

authors

Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

doi

10.1016/0264-410x(94)90336-0

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

1004-11

issue

11

eissn

0264-410X

issn

1873-2518

pii

0264-410X(94)90336-0

journal_volume

12

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies.

    abstract：:Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual influenza vaccination is recommended for all pregnant women in the United States. Women frequently cite concerns about vaccine safety as a barrier to vaccination. This review ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2014.04.021

    authors： Naleway AL,Irving SA,Henninger ML,Li DK,Shifflett P,Ball S,Williams JL,Cragan J,Gee J,Thompson MG,Vaccine Safety Datalink and Pregnancy and Influenza Project.

    更新日期：2014-05-30 00:00:00

  • Induction of anti-viral immune responses by immunization with recombinant-DNA encoded avian coronavirus nucleocapsid protein.

    abstract：:Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90028-i

    authors： Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

    更新日期：1992-01-01 00:00:00

  • Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity.

    abstract：:A dengue virus vaccine candidate, rDEN4Delta30, has been previously reported to be safe and immunogenic in humans, but a subset of vaccinees developed asymptomatic rash, elevation of liver enzymes and/or mild neutropenia. In the current study, mutations that had previously been shown to reduce replication of DEN4 viru...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.02.031

    authors： Hanley KA,Manlucu LR,Manipon GG,Hanson CT,Whitehead SS,Murphy BR,Blaney JE Jr

    更新日期：2004-09-03 00:00:00

  • Implementation of a Q fever vaccination program for high-risk patients in the Netherlands.

    abstract：BACKGROUND:Between 2007 and 2011 the Netherlands was faced with an unprecedented Q fever outbreak with more than 4000 people affected. Dairy goats were considered the main source of infection. In addition to taking veterinary measures, the Dutch government offered an unlicensed vaccine against the causative bacterium C...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.03.062

    authors： Isken LD,Kraaij-Dirkzwager M,Vermeer-de Bondt PE,Rümke HC,Wijkmans C,Opstelten W,Timen A

    更新日期：2013-05-28 00:00:00

  • Human papillomavirus (HPV) vaccination and subsequent sexual behaviour: evidence from a large survey of Nordic women.

    abstract：OBJECTIVE:To assess whether recipients and non-recipients of the human papillomavirus (HPV) vaccine subsequently differ in terms of sexual risk taking behaviour. DESIGN:Cross-sectional survey. Sequential analyses constructed from self-reported age at vaccination, age at first intercourse and age at response. SETTING:...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.07.025

    authors： Hansen BT,Kjær SK,Arnheim-Dahlström L,Liaw KL,Jensen KE,Thomsen LT,Munk C,Nygård M

    更新日期：2014-09-03 00:00:00

  • Long-lasting balanced immunity and protective efficacy against respiratory syncytial virus in mice induced by a recombinant protein G1F/M2.

    abstract：:Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in young children. We have engineered a recombinant candidate vaccine G1F/M2, consisting of a cytotoxic T lymphocyte (CTL) epitope of RSV-M2 protein and a domain of RSV-G protein. In this study, the long-term immunogenici...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.08.007

    authors： Zeng R,Qi X,Gong W,Mei X,Wei L,Ma C,Yin X

    更新日期：2007-10-16 00:00:00

  • Innate immunemodulator containing adjuvant formulated HA based vaccine protects mice from lethal infection of highly pathogenic avian influenza H5N1 virus.

    abstract：:The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.051

    authors： Lu Y,Landreth S,Liu G,Brownlie R,Gaba A,Littel-van den Hurk SVD,Gerdts V,Zhou Y

    更新日期：2020-02-28 00:00:00

  • Immune effects of the vaccine of live attenuated Aeromonas hydrophila screened by rifampicin on common carp (Cyprinus carpio L).

    abstract：:Aeromonas hydrophila, as a strong Gram-negative bacterium, can infect a wide range of freshwater fish, including common carp Cyprinus carpio, and cause the huge economic loss. To create the effective vaccine is the best way to control the outbreak of the disease caused by A. hydrophila. In this study, a live attenuate...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.04.075

    authors： Jiang X,Zhang C,Zhao Y,Kong X,Pei C,Li L,Nie G,Li X

    更新日期：2016-06-08 00:00:00

  • Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus.

    abstract：:Respiratory syncytial virus F-protein (RSV-F) is poorly expressed from DNA expression plasmids containing the wild type RSV-F open reading frame. By codon optimization, premature polyadenylation signals were deleted and a striking enhancement of RSV-F expression levels was achieved. Therefore, the immunogenicity and e...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.025

    authors： Ternette N,Tippler B,Uberla K,Grunwald T

    更新日期：2007-10-10 00:00:00

  • RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.

    abstract：:Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitonea...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.08.018

    authors： Smallshaw JE,Richardson JA,Vitetta ES

    更新日期：2007-10-16 00:00:00

  • Global distribution of group A rotavirus strains in horses: a systematic review.

    abstract：:Group A rotavirus (RVA) is a major cause of diarrhea and diarrhea-related mortality in foals in parts of the world. In addition to careful horse farm management, vaccination is the only known alternative to reduce the RVA associated disease burden on horse farms. The precise evaluation of vaccine effectiveness against...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2013.08.045

    authors： Papp H,Matthijnssens J,Martella V,Ciarlet M,Bányai K

    更新日期：2013-11-19 00:00:00

  • Coxiella burnetii: host and bacterial responses to infection.

    abstract：:Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. Advances in the study of this microorganism proceeded slowly, p...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2007.08.002

    authors： Waag DM

    更新日期：2007-10-16 00:00:00

  • Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum.

    abstract：:Cysteine peptidases (CPs) have been implicated in various processes central to the pathogenicity of Leishmania parasites, and are thought to be key factors in the host-parasite interaction. In order to fully evaluate the potential of the CPs as vaccine candidates, studies in natural host species are required. In the s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.12.039

    authors： Poot J,Spreeuwenberg K,Sanderson SJ,Schijns VE,Mottram JC,Coombs GH,Vermeulen AN

    更新日期：2006-03-24 00:00:00

  • Strengthening of causality assessment of adverse events following immunization in the WHO South East Asia and Western Pacific regions: Lessons from the 2014 SEAR inter-country workshop.

    abstract：BACKGROUND:Poorly managed AEFI undermine immunization programs. Improved surveillance in SEAR countries means more AEFIs but management varies. SEAR brought countries together to share AEFI experiences, and learn more about causality assessment. METHODS:Three day 10 country workshop (9 SEAR; 1 WPR). Participants outli...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.01.033

    authors： MacDonald NE,Guichard S,Amarasinghe A,Balakrishnan MR,2014 Inter-country SEAR Workshop Participants.

    更新日期：2015-11-27 00:00:00

  • Immunogenicity and protective efficacy of an inactivated cell culture-derived Seneca Valley virus vaccine in pigs.

    abstract：:Seneca Valley virus (SVV) infection in pigs is associated with porcine idiopathic vesicular disease (PIVD). Outbreaks of SVV infection in pig herds have been reported in several Asia and Americas countries. Recently, a series of outbreaks of SVV infection occurred in China, Canada, Thailand and the United States. Howe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.12.055

    authors： Yang F,Zhu Z,Cao W,Liu H,Zhang K,Tian H,Liu X,Zheng H

    更新日期：2018-02-01 00:00:00

  • Development of a Rift Valley fever virus viremia challenge model in sheep and goats.

    abstract：:Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, causes severe to fatal disease in newborn ruminants, as well as abortions in pregnant animals; both preventable by vaccination. Availability of a challenge model is a pre-requisite for vaccine efficacy trials. Several modes of inoculation with RVFV Z...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.02.066

    authors： Weingartl HM,Miller M,Nfon C,Wilson WC

    更新日期：2014-04-25 00:00:00

  • Recombinant subunit vaccines protect guinea pigs from lethal Ebola virus challenge.

    abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.035

    authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

    更新日期：2019-11-08 00:00:00

  • Age-dependent tolerance to an endogenous tumor-associated antigen.

    abstract：:Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.01.052

    authors： McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE

    更新日期：2008-03-28 00:00:00

  • Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules.

    abstract：:Human papillomavirus type 16 (HPV16)-transformed mouse TC-1 cells are extensively used in the evaluation of efficacy of experimental vaccines against tumours induced by HPVs. As these cells strongly express MHC class I molecules and downregulation of MHC class I surface expression is one of the important mechanisms th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00519-4

    authors： Smahel M,Síma P,Ludvíková V,Marinov I,Pokorná D,Vonka V

    更新日期：2003-03-07 00:00:00

  • Epidemiology and costs of herpes zoster: background data to estimate the impact of vaccination.

    abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.049

    authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

    更新日期：2007-10-23 00:00:00

  • Mumps disease in Beijing in the era of two-dose vaccination policy, 2005-2016.

    abstract：BACKGROUND:Since the introduction of mumps-containing vaccines (MuCV) in 1995 in Beijing, two-dose MuCV vaccination policy has been used, with the 1st and 2nd doses given at 18 months and 6 years of age, respectively. METHODS:Mumps epidemiology during 2005-2016 was described using surveillance data. Vaccine effectiven...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.03.074

    authors： Ma R,Lu L,Zhou T,Pan J,Chen M,Pang X

    更新日期：2018-05-03 00:00:00

  • Vaccination coverage among social and healthcare workers in ten countries of Samu-social international sites.

    abstract：BACKGROUND:We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS:Data on immunization coverage of social and healthcare ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.014

    authors： Marshall E,Salmon D,Bousfiha N,Togola Y,Ouedraogo F,Santantonio M,Dieng CK,Tartière S,Emmanuelli X

    更新日期：2017-09-18 00:00:00

  • Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study.

    abstract：BACKGROUND:We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children in developing countries and in travelers. METHODS:The vaccine was tested for safety and immunogenicity alone and together with double-mutant heat-labile toxi...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2014.10.069

    authors： Lundgren A,Bourgeois L,Carlin N,Clements J,Gustafsson B,Hartford M,Holmgren J,Petzold M,Walker R,Svennerholm AM

    更新日期：2014-12-12 00:00:00

  • Evaluation of endotoxin content of diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines that interfere with the bacterial endotoxin test.

    abstract：:Applicability of the endotoxin test to diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines was examined. We found some DTaP vaccines that strongly interfered with Limulus amoebocyte lysate (LAL) activity of endotoxin without affecting lethal activity of endotoxin in D-galactosamine-treated mice. LAL activi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00006-9

    authors： Ochiai M,Kataoka M,Toyoizumi H,Kamachi K,Yamamoto A,Horiuchi Y

    更新日期：2003-05-16 00:00:00

  • Development of an in vitro-based potency assay for anthrax vaccine.

    abstract：:The potency assay currently used to evaluate consistency of manufacture for the anthrax vaccine is contingent upon meeting specified parameters after statistical analysis of the percent survival and time to death of vaccinated guinea pigs after challenge with spores of a virulent strain of Bacillus anthracis. During t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.12.027

    authors： Little SF,Webster WM,Ivins BE,Fellows PF,Norris SL,Andrews GP

    更新日期：2004-07-29 00:00:00

  • Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica.

    abstract：:Cattle produce specific serum antibody mainly of the IgG1 isotype in response to infection with the liver fluke, Fasciola hepatica. In these animals a positive correlation between fluke-specific serum IgG1 levels and fluke-burden in non-immunized infected animals was observed. In contrast, immunization of cattle with ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00289-2

    authors： Mulcahy G,O'Connor F,McGonigle S,Dowd A,Clery DG,Andrews SJ,Dalton JP

    更新日期：1998-05-01 00:00:00

  • Comparative incidence dynamics and serotypes of meningitis, bacteremic pneumonia and other-IPD in young children in the PCV era: Insights from Israeli surveillance studies.

    abstract：INTRODUCTION:Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumo...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.059

    authors： Ben-Shimol S,Givon-Lavi N,Grisaru-Soen G,Megged O,Greenberg D,Dagan R,Israel Bacteremia and Meningitis Active Surveillance Group.

    更新日期：2018-08-28 00:00:00

  • Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice.

    abstract：:A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protect...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.07.087

    authors： Tang LH,Lim JH,Kuah LF,Lau YF

    更新日期：2014-09-22 00:00:00

  • Invasive pneumococcal disease: Clinical outcomes and patient characteristics 2-6 years after introduction of 7-valent pneumococcal conjugate vaccine compared to the pre-vaccine period, the Netherlands.

    abstract：BACKGROUND:Implementation of 7-valent pneumococcal conjugate vaccine (PCV7) in the Dutch national immunization program for infants led to a shift from vaccine to non-vaccine serotypes in invasive pneumococcal disease (IPD) in all age groups. We studied the impact of the serotype shift on clinical syndromes and outcomes...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.12.066

    authors： Wagenvoort GH,Sanders EA,Vlaminckx BJ,Elberse KE,de Melker HE,van der Ende A,Knol MJ

    更新日期：2016-02-17 00:00:00

  • Construction and cellular immune response induction of HA-based alphavirus replicon vaccines against human-avian influenza (H5N1).

    abstract：:Several approaches are being taken worldwide to develop vaccines against H5N1 viruses; most of them, however, pose both practical and immunological challenges. One potential strategy for improving the immunogenicity of vaccines involves the use of alphavirus replicons and VP22, a herpes simplex type 1 (HSV-1) protein....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.05.014

    authors： Yang SG,Wo JE,Li MW,Mi FF,Yu CB,Lv GL,Cao HC,Lu HF,Wang BH,Zhu H,Li LJ

    更新日期：2009-12-09 00:00:00