Abstract：
:Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. Advances in the study of this microorganism proceeded slowly, primarily because of the difficulty in studying this obligate intracellular pathogen that must be manipulated under biosafety level-3 conditions. The dogged determination of past and current C. burnetii researchers and the application of modern immunological and molecular techniques have more clearly defined the host and bacterial response to infection. This review is intended to provide a basic introduction to C. burnetii and Q fever, while emphasizing immunomodulatory properties, both positive and negative, of Q fever vaccines and C. burnetii infections.
journal_name
Vaccinejournal_title
Vaccineauthors
Waag DMdoi
10.1016/j.vaccine.2007.08.002subject
Has Abstractpub_date
2007-10-16 00:00:00pages
7288-95issue
42eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00915-2journal_volume
25pub_type
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