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Recombinant gp160 vaccination schedule and MHC HLA type as factors influencing cellular responses to HIV-1 envelope glycoprotein. NIAID AIDS Vaccine Clinical Trials Network.

Abstract：

:This study assessed (1) T-cell responses following vaccination of HIV-1 negative volunteers with HIV-1LAI recombinant gp160 (rgp160) vaccine, and (2) effects of vaccine injection schedule and MHC HLA type on those responses. In one trial, volunteers received rgp160 in two accelerated schedules (Groups 1 and 2). In the other trial, volunteers received rgp160 vaccine at 0, 1, 6, and 12 months and some received vaccine at 18 months (Groups 3 and 4). Peripheral blood mononuclear cells (PBMC) from vaccinees in Groups 3 and 4 were stimulated by more peptides representing envelope glycoprotein T-cell epitopes than Groups 1 and 2 (p = 0.01). Transient anti-envelope glycoprotein CTL activity was more frequently detectable in Groups 1 and 2 (p = 0.03). MHC HLA-Cw7, DR1 and DQw1 alleles appeared to be associated with PBMC responses to envelope glycoprotein.

journal_name

Vaccine

journal_title

Vaccine

authors

Gorse GJ,Patel GB,Newman FK,Mandava M,Belshe RB

doi

10.1016/0264-410x(95)00020-2

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

1170-9

issue

13

eissn

0264-410X

issn

1873-2518

pii

0264410X95000202

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验

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