Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.

abstract：:Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenz...

journal_title：Vaccine

authors： Iwasaki A,Dela Cruz CS,Young AR,Barber BH

更新日期：1999-04-09 00:00:00

abstract：:Dendritic cells (DC) play an integral role in plasmid DNA vaccination. However, the interaction between plasmid DNA and DC in vivo is incompletely understood. In this report, we utilise the sheep pseudoafferent cannulation model to examine the interaction between plasmid DNA encoding enhanced green fluorescent protein...

journal_title：Vaccine

authors： Watkins C,Hopkins J,Harkiss G

更新日期：2005-07-21 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV....

journal_title：Vaccine

authors： Liu J,Chen X,Lin L,Tan C,Chen Y,Guo Y,Jin M,Guo A,Bei W,Chen H

更新日期：2007-11-01 00:00:00

abstract：:We evaluated the prevalence and concentration of serum antibodies 18-24 months after primary inoculation with anthrax and botulinum vaccines, and assessed the reactogenicity and immunogenicity of a significantly delayed booster dose of these vaccines. Five hundred and eight male active-duty military personnel received...

journal_title：Vaccine

authors： Pittman PR,Hack D,Mangiafico J,Gibbs P,McKee KT Jr,Friedlander AM,Sjogren MH

更新日期：2002-05-15 00:00:00

abstract：:Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prev...

journal_title：Vaccine

authors： Ferrantelli F,Rasmussen RA,Hofmann-Lehmann R,Xu W,McClure HM,Ruprecht RM

更新日期：2002-12-19 00:00:00

abstract：:The objective of this study was to investigate the prevalence of hepatitis B markers in a representative sample of 2142 subjects in Catalonia, Spain, and to compare it with previous studies. Multiple logistical regression analysis was carried out to determine variables associated with the markers studied. The prevalen...

journal_title：Vaccine

authors： Domínguez A,Bruguera M,Vidal J,Plans P,Salleras L

更新日期：2000-05-08 00:00:00

abstract：:We studied with a mouse model and in piglets the requirements to prime for a secondary, mucosal B-cell response against Escherichia coli F4 fimbriae, an important virulence factor of enterotoxigenic E. coli, the agent associated with postweaning diarrhoea in piglets. The major observation obtained with the mouse model...

journal_title：Vaccine

authors： Bianchi AT,Scholten JW,van Zijderveld AM,van Zijderveld FG,Bokhout BA

更新日期：1996-02-01 00:00:00

abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

更新日期：1995-07-01 00:00:00

abstract：:We have previously shown that vaccination of BALB/c mice with a combination of BCG plus killed Leishmania promastigotes, applied by the i.p. route 10 and 3 days before Trypanosoma cruzi inoculation, prolonged their survival and decreased their parasitaemia. In the present study we show that the BCG-Leishmania vaccine ...

journal_title：Vaccine

authors： Araujo Z,Heremans H,Stordeur P,Wissing M,Goldman M,Castes M,Carlier Y

更新日期：2000-03-06 00:00:00

abstract：:About 10% of health care professionals vaccinated against hepatitis B virus (HBV) fail to develop protective antibodies. We tested the capacity of peripheral blood lymphocytes from 121 health care professionals, including 76 non-responders, to proliferate to four HBV vaccines, examined the proliferating cells' subset,...

journal_title：Vaccine

authors： Jarrosson L,Kolopp-Sarda MN,Aguilar P,Béné MC,Lepori ML,Vignaud MC,Faure GC,Kohler C

更新日期：2004-09-09 00:00:00

abstract：:Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the developm...

journal_title：Vaccine

authors： Julkunen I,Melén K,Nyqvist M,Pirhonen J,Sareneva T,Matikainen S

更新日期：2000-12-08 00:00:00

abstract：:Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, et al. Vaccine 2005;23:2956-8]. To invest...

journal_title：Vaccine

authors： Pugachev KV,Schwaiger J,Brown N,Zhang ZX,Catalan J,Mitchell FS,Ocran SW,Rumyantsev AA,Khromykh AA,Monath TP,Guirakhoo F

更新日期：2007-09-17 00:00:00

abstract：:The ability to readily elicit broadly neutralizing antibodies to HIV-1 remains elusive. We and others have hypothesized that interaction of the viral envelope glycoprotein (Env, gp120-gp41) with its receptor molecules could enhance the exposure of conserved epitopes that may facilitate the elicitation of broadly neutr...

journal_title：Vaccine

authors： Xiao X,Phogat S,Shu Y,Phogat A,Chow YH,Wei OL,Goldstein H,Broder CC,Dimitrov DS

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To determine human papillomavirus (HPV) prevalence and type-distribution in women from South Asia, with and without cervical lesions, in order to estimate the impact of an HPV 16/18 prophylactic vaccine in this region and to assess additional types that should be incorporated in new vaccines. METHODS:A meta-...

journal_title：Vaccine

authors： Bhatla N,Lal N,Bao YP,Ng T,Qiao YL

更新日期：2008-06-02 00:00:00

abstract：:A hospital-based case-control study was carried out at the Vilela Children's Hospital in Rosario, Argentina, to measure the protection conferred by BCG vaccination against tuberculosis (TB). The study included 148 newly diagnosed cases of TB (75 males and 73 females, mean age 3.34+/-2.97 years, S.D.), 134 of them with...

journal_title：Vaccine

authors： Bonifachich E,Chort M,Astigarraga A,Diaz N,Brunet B,Pezzotto SM,Bottasso O

更新日期：2006-04-05 00:00:00

abstract：:Seasonal influenza epidemics are associated with high morbidity and mortality particularly in high-risk patients. Conventionally administered influenza vaccines show reduced efficacy in populations with weakened immune systems such as solid-organ transplant patients. This study assesses the safety and immunogenicity o...

journal_title：Vaccine

authors： Morelon E,Pouteil Noble C,Daoud S,Cahen R,Goujon-Henry C,Weber F,Laurent PE,Kaiserlian D,Nicolas JF

更新日期：2010-10-04 00:00:00

abstract：:Gram-negative bacterial outer membrane proteins (Omps) have an important role in pathogenesis and signal reception. We previously reported that Acinetobacter OmpA (AbOmpA) induced maturation of bone marrow-derived dendritic cells (BMDCs) and that AbOmpA-primed DCs produced IL-12 which generated Th1 CD4(+) T-cells. We ...

journal_title：Vaccine

authors： Jang MJ,Kim JE,Chung YH,Lee WB,Shin YK,Lee JS,Kim D,Park YM

更新日期：2011-03-16 00:00:00

abstract：:An inactivated hepatitis A vaccine was given to 104 seronegative volunteers aged between 19 and 60 years according to two schedules: 0, 1 and 2 months or 0, 1 and 6 months. The vaccine was well tolerated and 97 and 100% of vaccinees developed a serum antibody response following a single and two doses of vaccine respec...

journal_title：Vaccine

authors： Tilzey AJ,Palmer SJ,Barrow S,Perry KR,Tyrell H,Safary A,Banatvala JE

更新日期：1992-01-01 00:00:00

abstract：:An ideal prophylactic human papillomavirus (HPV) vaccine would provide broadly protective and long-lasting immune responses against all high-risk HPV types, would be effective after a single dose, and would be formulated in such a manner to allow for long-term storage without the necessity for refrigeration. We have d...

journal_title：Vaccine

authors： Tumban E,Muttil P,Escobar CA,Peabody J,Wafula D,Peabody DS,Chackerian B

更新日期：2015-06-26 00:00:00

abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

journal_title：Vaccine

authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

更新日期：2000-11-22 00:00:00

abstract：:Langmuir adsorption isotherms of endotoxin and aluminum-containing adjuvants at pH 7.4 and 25 degrees C revealed that aluminum hydroxide adjuvant has a greater adsorption capacity (283 microg/mg Al) and adsorption coefficient (1.3x10(4) ml/miccrog) than aluminum phosphate adjuvant (3.0 microg/mg Al, 0.20 ml/microg). T...

journal_title：Vaccine

authors： Shi Y,HogenEsch H,Regnier FE,Hem SL

更新日期：2001-02-08 00:00:00

abstract：:NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimic...

journal_title：Vaccine

authors： Fernandes da Costa SP,Mot D,Bokori-Brown M,Savva CG,Basak AK,Van Immerseel F,Titball RW

更新日期：2013-08-20 00:00:00

abstract：:ChimeriVax is a live, attenuated recombinant virus constructed from yellow fever (YF) 17D in which the envelope protein genes of YF 17D are replaced with the corresponding genes of another flavivirus. A ChimeriVax vaccine was developed against Japanese encephalitis (JE). A randomized, double-blind, outpatient study wa...

journal_title：Vaccine

authors： Monath TP,McCarthy K,Bedford P,Johnson CT,Nichols R,Yoksan S,Marchesani R,Knauber M,Wells KH,Arroyo J,Guirakhoo F

更新日期：2002-01-15 00:00:00

abstract：:Presence of maternally-derived antibodies at time of immunization is known to often interfere with active infant immunization, although with variable degrees of clinical significance. In order to progressively decipher the rules that form the basis for these inhibitory effects on infant vaccine responses, two antigens...

journal_title：Vaccine

authors： Siegrist CA,Córdova M,Brandt C,Barrios C,Berney M,Tougne C,Kovarik J,Lambert PH

更新日期：1998-08-01 00:00:00

abstract：:We examined the immunogenicity and protective efficacy of a combined DNA vaccine that included six genes encoding immunodominant antigens from Mycobacterium tuberculosis and Brucella abortus. The IL-12 adjuvant system was used for immunization in combination with the combined DNA vaccine (DNA-IL-12(+)). Mice immunized...

journal_title：Vaccine

authors： Yu DH,Li M,Hu XD,Cai H

更新日期：2007-09-17 00:00:00

abstract：:The low-molecular-mass secretory proteins of Mycobacterium tuberculosis have been shown to be major T-cell antigens during infection with the pathogenic bacterium. In this study, we determined murine T-cell epitopes on three low-molecular-mass proteins, CFP11 (Rv2433c), CFP17 (Rv1827), and TB18.5 (Rv0164) using DNA im...

journal_title：Vaccine

authors： Eweda G,Suzuki D,Nagata T,Tsujimura K,Koide Y

更新日期：2010-06-23 00:00:00

abstract：:Yellow Fever (YF) is an acute febrile illness caused by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to humans and non-human primates. In Brazil, YF is a public health threat and may cause recurrent epidemics, even with the availability of a vaccine. We evaluated the sero-status for YFV in 581 ind...

journal_title：Vaccine

authors： Stoffella-Dutra AG,Silva de Oliveira J,Barbosa Costa G,Geessien Kroon E,Santos Abrahão J,Desiree LaBeaud A,Paiva Drumond B,Bretas de Oliveira D,de Souza Trindade G

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Advanced age and human immunodeficiency virus (HIV) infection are associated with increased pneumococcal disease risk. The impact of these factors on cellular responses to vaccination is unknown. METHODS:HIV-infected (HIV+) individuals 50-65 years old with CD4(+) Tcells/μl (CD4) >200 on antiretroviral thera...

journal_title：Vaccine

authors： Ohtola JA,Khaskhely NM,Saul-Mcbeth JL,Iyer AS,Leggat DJ,Khuder SA,Westerink MAJ

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:Currently, one lifetime booster of a 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for those at highest risk of invasive pneumococcal disease (IPD) 3-5 years after initial vaccination. Due to a lack of evidence on multiple revaccinations, recommendations on repeat revaccination do not ...

journal_title：Vaccine

authors： Caya CA,Boikos C,Desai S,Quach C

更新日期：2015-03-10 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00