Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens.

Abstract:

:The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulation of MDV and HVT genomes in the lungs compared to the chickens that received HVT or MDV alone. This increase in virus load was associated with augmented expression of interferon (IFN)-gamma and interleukin (IL)-10, and increased T cell infiltration. These findings shed more light on the immunological events that occur in the lungs after vaccination or infection with MDV.

journal_name

Vaccine

journal_title

Vaccine

authors

Haq K,Abdul-Careem MF,Shanmuganthan S,Thanthrige-Don N,Read LR,Sharif S

doi

10.1016/j.vaccine.2010.06.036

subject

Has Abstract

pub_date

2010-08-02 00:00:00

pages

5565-72

issue

34

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)00847-9

journal_volume

28

pub_type

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