Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus.

abstract：:Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...

journal_title：Vaccine

authors： Mahmoud A

更新日期：2017-01-20 00:00:00

abstract：:There is a need for more efficient vaccines to combat viral diseases of Atlantic salmon and other farmed fish. DNA vaccines are highly effective against salmonid rhabdoviruses, but have shown less effect against other viruses. In the present work we have studied if type I IFNs might be used as adjuvants in fish DNA va...

journal_title：Vaccine

authors： Chang CJ,Sun B,Robertsen B

更新日期：2015-05-15 00:00:00

abstract：:A trial of the ALVAC-AIDSVAX HIV vaccine was recently found to be partially effective in preventing HIV transmission among study participants in Thailand. The success of this trial means that vaccination may become a viable intervention for the prevention of HIV infection in the medium-term future. Assuming that the v...

journal_title：Vaccine

authors： Gray RT,Ghaus MH,Hoare A,Wilson DP

更新日期：2011-08-18 00:00:00

abstract：:DNA vaccination is a promising alternative strategy for developing new human and animal vaccines. The massive efforts made these past 25 years to increase the immunizing potential of this kind of vaccine are still ongoing. A relatively small number of studies concerning poultry have been published. Even though there i...

journal_title：Vaccine

authors： Meunier M,Chemaly M,Dory D

更新日期：2016-01-04 00:00:00

abstract：:Shigella and enterotoxigenic Escherichia coli continue to be significant causes of diarrheal disease in infants and young children in developing countries as well as prevalent agents of traveler's diarrhea. A vaccine which provides protection against disease caused by both pathogens would serve common at-risk populati...

journal_title：Vaccine

authors： Barry EM,Wang J,Wu T,Davis T,Levine MM

更新日期：2006-05-01 00:00:00

abstract：:Measles vaccine is widely used, most often in association with mumps and rubella vaccines. We report here the case of a child presenting with fever 8 days after vaccination with a measles-mumps-rubella vaccine. Measles virus was isolated in a throat swab taken 4 days after fever onset. This virus was then further gene...

journal_title：Vaccine

authors： Morfin F,Beguin A,Lina B,Thouvenot D

更新日期：2002-02-22 00:00:00

abstract：:Using HIV-1 envelope protein (Env)-based immunogens that closely mimic the conformation of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical region is considered a rational approach towards developing HIV vaccine. We recently reported that like clade B Env, JRFL, membrane bound Indian...

journal_title：Vaccine

authors： Shrivastava T,Samal S,Tyagi AK,Goswami S,Kumar N,Ozorowski G,Ward AB,Chakrabarti BK

更新日期：2018-03-14 00:00:00

abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...

journal_title：Vaccine

authors： Fiebelkorn AP,Seward JF,Orenstein WA

更新日期：2014-08-27 00:00:00

abstract：:The replication of simian immunodeficiency virus (SIV) in acutely infected CD4+ cells can be inhibited in vitro by CD8-suppressor factors (SF) and beta-chemokines induced by immunization of macaques with SIV gp120 and p27 in Alum. A comparison between intradermal, naso-rectal-i.m. and targeted iliac lymph node (TILN) ...

journal_title：Vaccine

authors： Wang Y,Tao L,Mitchell E,Bergmeier L,Doyle C,Lehner T

更新日期：1999-04-09 00:00:00

abstract：:ArtinM and Jacalin (JAC) are lectins from the jackfruit (Artocarpus integrifolia) that have important role in modulation of immune responses to pathogens. Neospora caninum is an Apicomplexa parasite that causes neuromuscular disease in dogs and reproductive disorders in cattle, with economic impact on the livestock in...

journal_title：Vaccine

authors： Cardoso MR,Mota CM,Ribeiro DP,Santiago FM,Carvalho JV,Araujo EC,Silva NM,Mineo TW,Roque-Barreira MC,Mineo JR,Silva DA

更新日期：2011-11-15 00:00:00

abstract：:Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...

journal_title：Vaccine

authors： Tamura S

更新日期：2010-08-31 00:00:00

abstract：:The comparison between fetal and maternal levels of immunoglobulins indicate that the human placenta during pregnancy develops a specific transport mechanism for IgG in the maternal to fetal direction. There are differences for the four subclasses, with preferential transfer of IgG(1) while the slowest transfer is see...

journal_title：Vaccine

authors： Malek A

更新日期：2003-07-28 00:00:00

abstract：:Neospora caninum is a causative and transmissible agent of dog and bovine neosporosis. The resulting reproductive failures in infected cattle lead to significant economic losses worldwide. However, there is no satisfactory treatment or vaccine currently available to combat this pathogen. Thus, the development of appro...

journal_title：Vaccine

authors： Xu J,Hiramatsu R,Suhaimi H,Kato T,Fujimoto A,Tokiwa T,Ike K,Park EY

更新日期：2019-10-08 00:00:00

abstract：BACKGROUND:Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae pro...

journal_title：Vaccine

authors： Szenborn L,Osipova IV,Czajka H,Kharit SM,Jackowska T,François N,Habib MA,Borys D

更新日期：2017-09-25 00:00:00

abstract：:The immunogenicity of two meningococcal outer membrane vesicle (OMV) vaccines, namely the Norwegian wild-type OMV vaccine and the Dutch hexavalent PorA OMV vaccine, were examined in infant cynomolgus monkeys. For the first time, a wild-type- and a recombinant OMV vaccine were compared. Furthermore, the induction of me...

journal_title：Vaccine

authors： Rouppe van der Voort E,Schuller M,Holst J,de Vries P,van der Ley P,van den Dobbelsteen G,Poolman J

更新日期：2000-01-31 00:00:00

abstract：:The carbohydrate moieties on HIV-1 envelope glycoprotein (Env) act as shields to mask conserved neutralizing epitopes, while the hyperimmunogenic variable regions are immunodominant in inducing non-neutralizing antibodies, representing the major challenge for using Env as a vaccine candidate to induce broadly neutrali...

journal_title：Vaccine

authors： Fu M,Hu K,Hu H,Ni F,Du T,Shattock RJ,Hu Q

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:In addition to antigens, vaccines contain small amounts of preservatives, adjuvants, and residual substances from the manufacturing process. Some parents have concerns about the safety of these ingredients, yet no large epidemiological studies have specifically examined associations between health outcomes a...

journal_title：Vaccine

authors： Glanz JM,Newcomer SR,Daley MF,McClure DL,Baxter RP,Jackson ML,Naleway AL,Lugg MM,DeStefano F

更新日期：2015-11-27 00:00:00

abstract：:In the present study, we investigated the duration of protection afforded to pigs immunized in two different prime-boost regimens: one is homologus priming and boosting with a protein vaccine, and the other is priming with a DNA vaccine and boosting with the protein vaccine. Groups of pigs that received the same vacci...

journal_title：Vaccine

authors： Guo YJ,Sun SH,Zhang Y,Chen ZH,Wang KY,Huang L,Zhang S,Zhang HY,Wang QM,Wu D,Zhu WJ

更新日期：2004-09-28 00:00:00

abstract：:Trends in HPV vaccine awareness among parents of adolescent girls and boys (ages 13-17) and HPV vaccine uptake (≥1 dose) among girls (ages 13-17) were evaluated in Los Angeles County, California. Between 2007 and 2011, parental HPV vaccine awareness increased from 72% to 77% overall, with significant increases among m...

journal_title：Vaccine

authors： Nonzee NJ,Baldwin SB,Cui Y,Singhal R

更新日期：2018-02-28 00:00:00

abstract：:Neisseria meningitidis, the causative agent of invasive meningococcal disease (IMD), is classified into different serogroups defined by their polysaccharide capsules. Meningococcal serogroups A, B, C, W, and Y are responsible for most IMD cases, with serogroup B (MenB) causing a substantial percentage of IMD cases in ...

journal_title：Vaccine

authors： Findlow J,Bayliss CD,Beernink PT,Borrow R,Liberator P,Balmer P

更新日期：2020-11-17 00:00:00

abstract：:To circumvent limitations of poor antigen presentation and immunogenicity of DNA vaccines that target induction of CD8(+) T cell immunity, we have generated single chain MHC I trimers (MHC I SCTs) composed of a single polypeptide chain with a linear composition of antigenic peptide, β2-microglobulin, and heavy chain o...

journal_title：Vaccine

authors： Kim S,Zuiani A,Carrero JA,Hansen TH

更新日期：2012-03-09 00:00:00

abstract：:Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

journal_title：Vaccine

authors： Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

更新日期：2009-08-06 00:00:00

abstract：:During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1...

journal_title：Vaccine

authors： Kamada M,Nagai T,Kumagai T,Igarashi M,Ihara T,Okafuji T,Ochiai H,Sakiyama H,Shimomura K,Suzuki E,Torigoe S,Miyazaki C,Miyata A,Yuri K,Ito Y,Nakayama T,Kase T,Okuno Y

更新日期：2006-04-24 00:00:00

abstract：:The revised Standards for Adult Immunization Practice ("Standards"), published in 2014, recommend routine vaccination assessment, strong provider recommendation, vaccine administration or referral, and documentation of vaccines administered into immunization information systems (IIS). We assessed clinician and pharmac...

journal_title：Vaccine

authors： Granade CJ,Parker Fiebelkorn A,Black CL,Lutz CS,Srivastav A,Bridges CB,Ball SW,Devlin RG,Cloud AJ,Kim DK

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:US-bound refugees undergo required health assessments overseas to identify and treat communicable diseases of public health significance-such as pulmonary tuberculosis-before migration. Immunizations are not required, leaving refugees at risk for vaccine-preventable diseases. In response, the US Centers for ...

journal_title：Vaccine

authors： Mitchell T,Dalal W,Klosovsky A,Yen C,Phares C,Burkhardt M,Amin F,Froes I,Hamadeh A,Lynn SA,Quintanilla J,Doney AC,Cetron M,Weinberg M

更新日期：2021-01-03 00:00:00

abstract：:Triton X-100 (TX-100) is the most common surfactant used to split viruses during the production of influenza split-virus vaccines. It is a mild surfactant not known to denature the viral proteins; this property makes TX-100 useful for maintaining antigen conformational structure, and, as an added benefit, for partiall...

journal_title：Vaccine

authors： Sahin Z,Neeleman R,Haines J,Kayser V

更新日期：2019-02-14 00:00:00

abstract：:Young children are very susceptible to typhoid fever, emphasizing the need for vaccination in under five age groups. The parenteral Vi polysaccharide vaccine is not immunogenic in children under 2 years and the oral Ty21a vaccine (Vivotif) available in capsular formulation is only recommended for those over 5 years. W...

journal_title：Vaccine

authors： Bhuiyan TR,Choudhury FK,Khanam F,Saha A,Sayeed MA,Salma U,Lundgren A,Sack DA,Svennerholm AM,Qadri F

更新日期：2014-02-19 00:00:00

abstract：:Vaccination of health-care workers (HCWs) against seasonal influenza has been consistently recommended worldwide in order to prevent nosocomial transmission and ensure delivery of health-care services during outbreaks. We describe the effects of a nationwide campaign to promote influenza vaccination among HCWs working...

journal_title：Vaccine

authors： Dedoukou X,Nikolopoulos G,Maragos A,Giannoulidou S,Maltezou HC

更新日期：2010-08-23 00:00:00

abstract：:Carbopol is a polyanionic carbomer gel used in man for a variety of topical applications and drug delivery purposes. Here we show that subcutaneous administration of carbopol with glycoprotein antigens elicits unusually strong specific adaptive immune responses in mice. Recombinant soluble HIV-1 envelope glycoprotein ...

journal_title：Vaccine

authors： Krashias G,Simon AK,Wegmann F,Kok WL,Ho LP,Stevens D,Skehel J,Heeney JL,Moghaddam AE,Sattentau QJ

更新日期：2010-03-16 00:00:00

abstract：:The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...

journal_title：Vaccine

authors： Vicente S,Goins BA,Sanchez A,Alonso MJ,Phillips WT

更新日期：2014-03-26 00:00:00