Ex vivo human placenta models: transport of immunoglobulin G and its subclasses.

Abstract:

:The comparison between fetal and maternal levels of immunoglobulins indicate that the human placenta during pregnancy develops a specific transport mechanism for IgG in the maternal to fetal direction. There are differences for the four subclasses, with preferential transfer of IgG(1) while the slowest transfer is seen for IgG(2). Under in vitro perfusion conditions of human term placenta IgG, when compared to other proteins, showed a significantly higher transfer rate of its subclasses from the maternal to the fetal side, indicating a specific transport mechanism. There is a preferential transfer rate, highest for IgG(1) and lowest for IgG(2), similar to those observed under in vivo conditions. The similarity in transfer of anti-TT-IgG and tetanus antigen, which was observed under in vivo and in vitro conditions, may suggest the transport as antibody-antigen complex.

journal_name

Vaccine

journal_title

Vaccine

authors

Malek A

doi

10.1016/s0264-410x(03)00333-5

subject

Has Abstract

pub_date

2003-07-28 00:00:00

pages

3362-4

issue

24

eissn

0264-410X

issn

1873-2518

pii

S0264410X03003335

journal_volume

21

pub_type

杂志文章,评审

相关文献

VACCINE文献大全
  • Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates.

    abstract::The new intradermal DNA delivery technique, termed DNA tattooing might overcome the discrepancy between the encouraging immunogenicity results obtained with DNA vaccines in murine studies and the poor results obtained in non-human primates and humans, the so called "simian barrier". Here, we demonstrate a 10- to 100-f...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.03.091

    authors: Verstrepen BE,Bins AD,Rollier CS,Mooij P,Koopman G,Sheppard NC,Sattentau Q,Wagner R,Wolf H,Schumacher TN,Heeney JL,Haanen JB

    更新日期:2008-06-19 00:00:00

  • Complications of influenza and benefits of vaccination.

    abstract::Uncertainty regarding the benefits of influenza vaccination may contribute to the underutilization of this vaccine. We have conducted serial cohort studies using the administrative data bases of a Twin Cities based managed care organization to assess the impact of disease and benefits of vaccination among the elderly....

    journal_title:Vaccine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0264-410x(99)00105-x

    authors: Nichol KL

    更新日期:1999-07-30 00:00:00

  • Issues surrounding standardization of meningococcal group W135 serology.

    abstract::Group W135 polysaccharide vaccines were licensed without efficacy trials using the serum bactericidal antibody (SBA) assay as a surrogate of protection. Standardization of group A and C SBA assays has been largely achieved. However, no such efforts have been focussed on W135. Although W135 strains have been recommende...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/j.vaccine.2007.04.043

    authors: Balmer P,Borrow R

    更新日期:2007-09-03 00:00:00

  • Relative contribution of porcine reproductive and respiratory syndrome virus open reading frames 2-4 to the induction of protective immunity.

    abstract::The minor glycoproteins (GPs) of PRRSV, GP2, GP3, and GP4, form a heterotrimer that is required for viral infectivity, presumably due to its interaction with the key cellular receptor CD163. These 3GPs are encoded by open reading frames (ORFs) 2a, 3 and 4 (herein referred to as ORFs 2-4), respectively. The goal of thi...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.06.061

    authors: Kimpston-Burkgren K,Correas I,Osorio FA,Steffen D,Pattnaik AK,Fang Y,Vu HLX

    更新日期:2017-08-03 00:00:00

  • Knowledge and attitudes towards influenza vaccination of health care workers in emergency services.

    abstract::Annual vaccination rates among French health care workers (HCWs) are in decline even in Emergency Services to which patients at highest risk of influenza complications are admitted, and in which HCWs have the greatest risk of exposure to influenza from patients. We aimed here to identify knowledge and attitudes toward...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.11.086

    authors: Hulo S,Nuvoli A,Sobaszek A,Salembier-Trichard A

    更新日期:2017-01-05 00:00:00

  • Antigen adsorbed surface modified poly-ɛ-caprolactone microspheres stimulates both adaptive and innate immune response in fish.

    abstract::Surface modified poly-ɛ-caprolactone microspheres as an antigen carrier was explored in a fish model. Outer membrane vesicles of Edwardsiella tarda adsorbed on to surface modified poly-ɛ-caprolactone microspheres with chitosan and alginate induces both innate and adaptive immune responses which persist up to 63 days o...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.05.028

    authors: Behera T,Swain P

    更新日期:2012-07-27 00:00:00

  • Hepatitis B vaccination at three months of age: a successful strategy?

    abstract::Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2013.01.046

    authors: Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan A

    更新日期:2013-03-25 00:00:00

  • In vivo CTL induction with point-substituted ovalbumin peptides: immunogenicity correlates with peptide-induced MHC class I stability.

    abstract::Class I molecules are conformationally sensitive to peptide binding, prolonging the complex's half-life on the surface of the cell. By making a series of H2-Kb anchor motif amino acid point substitutions in the ovalbumin 257-264 octamer, we were able to analyse subtle changes in peptide binding, Kb stabilization and i...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(95)93320-9

    authors: Lipford GB,Bauer S,Wagner H,Heeg K

    更新日期:1995-02-01 00:00:00

  • Chimeric (marker) C-strain viruses induce clinical protection against virulent classical swine fever virus (CSFV) and reduce transmission of CSFV between vaccinated pigs.

    abstract::Two live recombinant vaccines (Flc9 and Flc11) against classical swine fever (CSF) were evaluated for their capacity to reduce transmission of virulent CSF virus (CSFV) among vaccinated pigs. In Flc9 the 5' terminal half of the E2 gene of the C-strain, a CSFV vaccine strain, was exchanged with the homologous gene of t...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(00)00347-9

    authors: de Smit AJ,Bouma A,van Gennip HG,de Kluijver EP,Moormann RJ

    更新日期:2001-01-08 00:00:00

  • Guideline for collection, analysis and presentation of safety data in clinical trials of vaccines in pregnant women.

    abstract::Vaccination during pregnancy is increasingly being used as an effective approach for protecting both young infants and their mothers from serious infections. Drawing conclusions from published studies in this area can be difficult because of the inability to compare vaccine trial results across different studies and s...

    journal_title:Vaccine

    pub_type: 指南,杂志文章

    doi:10.1016/j.vaccine.2016.07.032

    authors: Jones CE,Munoz FM,Spiegel HM,Heininger U,Zuber PL,Edwards KM,Lambach P,Neels P,Kohl KS,Gidudu J,Hirschfeld S,Oleske JM,Khuri-Bulos N,Bauwens J,Eckert LO,Kochhar S,Bonhoeffer J,Heath PT,Brighton Collaboration Immunizat

    更新日期:2016-12-01 00:00:00

  • Burden and trends of type-specific human papillomavirus infections and related diseases in the Asia Pacific region.

    abstract::We present the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital areas, and oral cavity and pharynx) in terms of incidence and mortality, for the countries of the Asia Pacific region. The region contains more than half of the world population, and manifests a wide geographic diver...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.05.010

    authors: Parkin DM,Louie KS,Clifford G

    更新日期:2008-08-19 00:00:00

  • Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120.

    abstract::Amino acid residues 421-436 constitute a comparatively conserved determinant of gp120 that participates in the binding of host cell CD4 receptors by HIV-1. We compared the immunogenicity of synthetic Cys-gp120 (421-436) conjugated to KLH via the N terminal Cys residue (KLH-I) and gp120 (421-436) extended at its N term...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(02)00504-2

    authors: Karle S,Nishiyama Y,Taguchi H,Zhou YX,Luo J,Planque S,Hanson C,Paul S

    更新日期:2003-03-07 00:00:00

  • In vivo evidence of immunological masking of the Vibrio cholerae O antigen of a hybrid Salmonella typhi Ty21a-Vibrio cholerae oral vaccine in humans.

    abstract::The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0264-410x(91)90039-9

    authors: Forrest BD,LaBrooy JT

    更新日期:1991-07-01 00:00:00

  • An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.

    abstract::Type I IFN and IL-12 are well documented to serve as so called "signal 3" cytokines, capable of facilitating CD8(+) T cell proliferation, effector function and memory formation. While their ability to serve in this capacity is well established, to date, no non-cytokine signal 3 mediators have been clearly identified. ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.12.017

    authors: Sanchez PJ,Kedl RM

    更新日期:2012-02-01 00:00:00

  • Noncytopathic bovine viral diarrhea virus can persist in testicular tissue after vaccination of peri-pubertal bulls but prevents subsequent infection.

    abstract::The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.09.037

    authors: Givens MD,Riddell KP,Walz PH,Rhoades J,Harland R,Zhang Y,Galik PK,Brodersen BW,Cochran AM,Brock KV,Carson RL,Stringfellow DA

    更新日期:2007-01-15 00:00:00

  • UV-inactivated vaccinia virus (VV) in a multi-envelope DNA-VV-protein (DVP) HIV-1 vaccine protects macaques from lethal challenge with heterologous SHIV.

    abstract::The pandemic of HIV-1 has continued for decades, yet there remains no licensed vaccine. Previous research has demonstrated the effectiveness of a multi-envelope, multi-vectored HIV-1 vaccine in a macaque-SHIV model, illustrating a potential means of combating HIV-1. Specifically, recombinant DNA, vaccinia virus (VV) a...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.03.001

    authors: Jones BG,Sealy RE,Zhan X,Freiden PJ,Surman SL,Blanchard JL,Hurwitz JL

    更新日期:2012-05-02 00:00:00

  • Enhanced cellular immune responses to SIV Gag by immunization with influenza and vaccinia virus recombinants.

    abstract::An effective vaccination strategy against human immunodeficiency virus type 1 (HIV-1) should include the induction of potent cellular immune responses against conserved HIV-1 antigens. We have generated five replication competent recombinant influenza viruses (rFlu/SIV Gag nos. 1-5) expressing different portions of Ga...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(02)00781-8

    authors: Nakaya Y,Zheng H,García-Sastre A

    更新日期:2003-05-16 00:00:00

  • Purification of O-specific polysaccharide from lipopolysaccharide produced by Salmonella enterica serovar Paratyphi A.

    abstract::The O specific polysaccharide (OSP) of the lipopolysaccharide (LPS) of Salmonella enterica serovar Paratyphi A is a protective antigen and the target for vaccine development. LPS is the major constituent of the outer membrane of S. Paratyphi A with the OSP exposed on the surface, in addition to the cell associated LPS...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.02.090

    authors: Kothari S,Kim JA,Kothari N,Jones C,Choe WS,Carbis R

    更新日期:2014-05-01 00:00:00

  • Active metabolite from Tamiflu solution is bioequivalent to that from capsule delivery in healthy volunteers: a cross-over, randomised, open-label study.

    abstract::The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule vers...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2006.05.080

    authors: Brewster M,Smith JR,Dutkowski R,Robson R

    更新日期:2006-11-10 00:00:00

  • Deinococcus Mn2+-peptide complex: A novel approach to alphavirus vaccine development.

    abstract::Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.05.016

    authors: Gayen M,Gupta P,Morazzani EM,Gaidamakova EK,Knollmann-Ritschel B,Daly MJ,Glass PJ,Maheshwari RK

    更新日期:2017-06-22 00:00:00

  • The smallpox vaccine induces an early neutralizing IgM response.

    abstract::The antibody response elicited after immunization with vaccinia virus (VacV) is known to be sufficient to confer host protection against VacV or smallpox. In humans it has been shown that such anti-VacV antibody production can be sustained for decades. Nevertheless, little is known about the kinetics and the role in p...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.09.086

    authors: Moyron-Quiroz JE,McCausland MM,Kageyama R,Sette A,Crotty S

    更新日期:2009-12-10 00:00:00

  • Transepithelial immunomodulation by cholera toxin and non-toxic derivatives.

    abstract::Comparative analyses of murine dendritic cells (DC) isolated from the skin and from the intestinal mucosa after exposure to cholera toxin and its non-toxic B subunit disclose striking differences regarding the migratory and functional behaviour of these cells. The nature of the epithelial microenvironment, especially ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2005.01.124

    authors: Anjuère F,Luci C,Hervouet C,Rousseau D,Czerkinsky C

    更新日期:2006-04-12 00:00:00

  • The changing landscape of respiratory syncytial virus.

    abstract::Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and develo...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/j.vaccine.2015.06.119

    authors: Polack FP

    更新日期:2015-11-25 00:00:00

  • Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis.

    abstract:BACKGROUND:Pseudotuberculosis is an infection caused by the bacterial enteropathogen Yersinia pseudotuberculosis and is considered to be a significant problem in veterinary medicine. We previously found that intranasal administration of a recombinant Lactococcus lactis strain that secretes the low-calcium response V (L...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.09.060

    authors: Daniel C,Titecat M,Poiret S,Cayet D,Boutillier D,Simonet M,Sirard JC,Lemaître N,Sebbane F

    更新日期:2016-11-11 00:00:00

  • Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis.

    abstract::A novel triterpenoidal saponin, called pulcherrimasaponin (CP05), isolated from the leaves of Calliandra pulcherrima Benth. shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina). On the basis of chemical and physicochemical evidence, its structure was estab...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2004.08.022

    authors: Silva BP,Soares JB,Souza EP,Palatnik M,Sousa CB,Parente JP

    更新日期:2005-01-11 00:00:00

  • Effect of emergency FMD vaccine antigen payload on protection, sub-clinical infection and persistence following direct contact challenge of cattle.

    abstract::Previous work, in sheep vaccinated with emergency foot-and-mouth disease (FMD) vaccine, indicated the benefit of increasing the antigen payload in inhibiting local virus replication and consequently persistence following an indirect aerosol challenge with a virus homologous to the vaccine strain. The work presented he...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.01.037

    authors: Cox SJ,Voyce C,Parida S,Reid SM,Hamblin PA,Hutchings G,Paton DJ,Barnett PV

    更新日期:2006-04-12 00:00:00

  • Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.

    abstract:BACKGROUND:The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children. METHODS:Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 mo...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.09.015

    authors: Seppälä E,Viskari H,Hoppu S,Honkanen H,Huhtala H,Simell O,Ilonen J,Knip M,Hyöty H

    更新日期:2011-11-03 00:00:00

  • Clinical effectiveness and cost-effectiveness of quadrivalent human papillomavirus vaccination in HIV-negative men who have sex with men to prevent recurrent high-grade anal intraepithelial neoplasia.

    abstract::We examined the long-term clinical and economic benefits of quadrivalent human papillomavirus (qHPV) vaccine as a secondary/adjunct prevention strategy in the prevention of recurrent high-grade intraepithelial neoplasia (HGAIN) in HIV-negative men who have sex with men (MSM) and are 27 years or older. We constructed a...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.10.052

    authors: Deshmukh AA,Chiao EY,Das P,Cantor SB

    更新日期:2014-12-05 00:00:00

  • HBV vaccination in hyperendemic remote tribal areas in India.

    abstract::Randomly selected 200 subjects were tested for quantitative hepatitis B surface antibody (HBsAb) estimation in a remote tribal area of Arunachal Pradesh, India to measure the protective immunity after vaccination in the backdrop of hyperendemic HBV infection. About 64.6 and 40.0% had HBsAb above 10 mIU/ml in the vacci...

    journal_title:Vaccine

    pub_type: 信件

    doi:10.1016/j.vaccine.2007.09.058

    authors: Borkakoty B,Mahanta J,Biswas D

    更新日期:2007-12-05 00:00:00

  • Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles.

    abstract::Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2019.09.041

    authors: Kwon YM,Lee Y,Kim KH,Jung YJ,Li Z,Jeeva S,Lee S,Moore ML,Kang SM

    更新日期:2019-10-16 00:00:00