Abstract：
:Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitoneally administered ricin. Furthermore the vaccine without alum was safe and immunogenic in human volunteers. Here we describe the development of gavage and aerosol ricin challenge models in mice and demonstrate that i.m. vaccination protects mice against ricin delivered by either route. Also RiVax protects against aerosol-induced lung damage as determined by histology and lung function tests.
journal_name
Vaccinejournal_title
Vaccineauthors
Smallshaw JE,Richardson JA,Vitetta ESdoi
10.1016/j.vaccine.2007.08.018subject
Has Abstractpub_date
2007-10-16 00:00:00pages
7459-69issue
42eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00913-9journal_volume
25pub_type
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