A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers.

abstract：:Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...

journal_title：Vaccine

authors： Baldridge JR,Ward JR

更新日期：1997-03-01 00:00:00

abstract：:Funded immunization programs are best able to achieve high participation rates, optimal protection of the target population, and indirect protection of others. However, in many countries public funding of approved vaccines can be substantially delayed, limited to a portion of the at-risk population or denied altogethe...

journal_title：Vaccine

authors： Scheifele DW,Ward BJ,Halperin SA,McNeil SA,Crowcroft NS,Bjornson G

更新日期：2014-02-07 00:00:00

abstract：:The hemagglutination inhibition (HI) assay is used most commonly for the detection of antibodies to influenza viruses. However, for the detection of antibodies to avian influenza viruses of the H5N1 subtype either induced by infection or by vaccination, the HI assay is insensitive. Therefore, the virus neutralization ...

journal_title：Vaccine

authors： Rimmelzwaan GF,Verburgh RJ,Nieuwkoop NJ,Bestebroer TM,Fouchier RA,Osterhaus AD

更新日期：2011-04-18 00:00:00

abstract：:The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternat...

journal_title：Vaccine

authors： Pyo HM,Masic A,Woldeab N,Embury-Hyatt C,Lin L,Shin YK,Song JY,Babiuk S,Zhou Y

更新日期：2012-02-08 00:00:00

abstract：:DNA vaccines have proven to be an efficient means of inducing immune responses in small laboratory animals; however, their efficacy in large out-bred animal models has been much less promising. In addressing this issue, we have investigated the ability of ovine cytotoxic lymphocyte antigen 4 (CTLA-4) mediated targetin...

journal_title：Vaccine

authors： Kennedy NJ,Spithill TW,Tennent J,Wood PR,Piedrafita D

更新日期：2006-02-13 00:00:00

abstract：:Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly 40%. To date, ther...

journal_title：Vaccine

authors： McVey DS,Chengappa MM,Mosier DE,Stone GG,Oberst RD,Sylte MJ,Gabbert NM,Kelly-Aehle SM,Curtiss R

更新日期：2002-02-22 00:00:00

abstract：:Salmonella enterica serovar Gallinarum causes fowl typhoid in chickens and is of economic importance to the chicken industry. A serovar Gallinarum live vaccine strain 9R (SG 9R) has been used to control fowl typhoid in many areas where the disease is endemic. Because the attenuation mechanism of SG 9R was not defined,...

journal_title：Vaccine

authors： Kang MS,Kwon YK,Kim HR,Oh JY,Kim MJ,An BK,Shin EG,Kwon JH,Park CK

更新日期：2012-10-05 00:00:00

abstract：:Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine pathogens that also serve as important large animal models of neonatal im...

journal_title：Vaccine

authors： Mealey RH,Stone DM,Hines MT,Alperin DC,Littke MH,Leib SR,Leach SE,Hines SA

更新日期：2007-10-23 00:00:00

abstract：:To test the possibility of developing a combined vaccine against hepatitis A and E, groups of mice were immunized with different formulations containing different dosages of a commercially inactivated hepatitis A vaccine and a candidate recombinant hepatitis E vaccine. Monovalent vaccine components were used as contro...

journal_title：Vaccine

authors： Dong C,Dai X,Meng JH

更新日期：2007-02-19 00:00:00

abstract：:Capsular polysaccharides of Streptococcus pneumoniae are used to formulate polyvalent pneumococcal vaccines. A sensitive method, using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD), has been developed to quantify the contamination of pneumococcal capsular polysaccharides...

journal_title：Vaccine

authors： Talaga P,Bellamy L,Moreau M

更新日期：2001-04-06 00:00:00

abstract：:Studies conducted at neonatal intensive care units in Pune, western India, suggested early exposure to rotaviruses and predominance of unusual human-bovine-like G12P[11] strains. The whole genome sequencing and phylogenetic analyses of a naturally attenuated, culture adapted neonatal strain, (NIV-1740121) revealed mul...

journal_title：Vaccine

authors： Ranshing SS,Cherian SS,Agarwal MS,Jagtap AS,Patil CM,Gopalkrishna V

更新日期：2020-02-28 00:00:00

abstract：:Trends in HPV vaccine awareness among parents of adolescent girls and boys (ages 13-17) and HPV vaccine uptake (≥1 dose) among girls (ages 13-17) were evaluated in Los Angeles County, California. Between 2007 and 2011, parental HPV vaccine awareness increased from 72% to 77% overall, with significant increases among m...

journal_title：Vaccine

authors： Nonzee NJ,Baldwin SB,Cui Y,Singhal R

更新日期：2018-02-28 00:00:00

abstract：BACKGROUND:MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine. For vaccine licensure, efficacy was inferred from serum bactericidal antibody (SBA) against three antigen-specific indicator strains. The bactericidal role of antibody to the fourth vaccine antigen, Neisserial Heparin binding antigen (...

journal_title：Vaccine

authors： Partridge E,Lujan E,Giuntini S,Vu DM,Granoff DM

更新日期：2017-07-24 00:00:00

abstract：:Pneumococcal and Salmonella typhi infections are two major diseases for children in developing countries. For typhoid fever, licensed Vi polysaccharide vaccines are ineffective in children <2-year old. While investigational Vi conjugate vaccines have been shown effective in clinical trials, they are currently only ava...

journal_title：Vaccine

authors： Lu YJ,Zhang F,Sayeed S,Thompson CM,Szu S,Anderson PW,Malley R

更新日期：2012-05-14 00:00:00

abstract：:Most traditional vaccines are administered via the intramuscular route. Other routes of administration however, can induce equal or improved protective memory responses and might provide practical advantages such as needle-free immunization, dose sparing and induction of tissue-specific (mucosal) immunity. Here we exp...

journal_title：Vaccine

authors： van Aalst S,Jansen MAA,Ludwig IS,van der Zee R,van Eden W,Broere F

更新日期：2018-03-07 00:00:00

abstract：:Few suspension cells can be used for vaccine manufacturing today as they either do not meet requirements from health regulatory authorities or do not produce high virus titres. Two new avian designer cell lines (AGE1.CR and AGE1.CR.pIX) that have been adapted to grow in suspension in serum-free medium were evaluated f...

journal_title：Vaccine

authors： Lohr V,Rath A,Genzel Y,Jordan I,Sandig V,Reichl U

更新日期：2009-08-06 00:00:00

abstract：:Outer membrane protein PhoE of Escherichia coli was used for the expression of antigenic determinants of foot-and-mouth disease virus. Five hybrid PhoE proteins were constructed containing different combinations of two antigenic determinants of VP1 protein of the virus. The hybrid proteins were expressed in two E. col...

journal_title：Vaccine

authors： Agterberg M,Adriaanse H,Lankhof H,Meloen R,Tommassen J

更新日期：1990-02-01 00:00:00

abstract：:Sulfated chitin derivatives, selected for their low toxicity and high inhibitory activity of melanoma metastasis, were examined for anti-viral activity against Friend murine leukaemia, herpes simplex type-1 (HSV) and Sendai viruses. Carboxymethyl chitin with a 7.66% degree of sulfation (SCM-chitin III) showed a signif...

journal_title：Vaccine

authors： Ishihara C,Yoshimatsu K,Tsuji M,Arikawa J,Saiki I,Tokura S,Azuma I

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:We sought to understand the relative advantage of pharmacies compared to doctors' offices for delivering HPV vaccination to adolescents. METHODS:Participants were a national sample of 1500 U.S. parents of adolescents ages 11-17 recruited in 2014-15. In an online survey, items informed by Diffusion of Innovatio...

journal_title：Vaccine

authors： Shah PD,Marciniak MW,Golden SD,Trogdon JG,Golin CE,Brewer NT

更新日期：2018-06-07 00:00:00

abstract：:Concerns about bioterrorism and outbreaks of zoonotic orthopoxvirus require safe and efficacious smallpox vaccines. We previously reported the clinical efficacy and safety profiles of LC16m8, a live, attenuated, cell culture-derived, smallpox vaccine, examined in over 3000 healthy Japanese adults with various vaccinat...

journal_title：Vaccine

authors： Eto A,Fujita M,Nishiyama Y,Saito T,Molina DM,Morikawa S,Saijo M,Shinmura Y,Kanatani Y

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Disparities in vaccine-preventable disease (VPD) burden and immunisation coverage between migrants and refugees and their host populations have been described in numerous countries worldwide. Effective strategies are required to reduce the health disparities and immunisation inequities experienced by migrant...

journal_title：Vaccine

authors： Charania NA,Gaze N,Kung JY,Brooks S

更新日期：2020-10-27 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive th...

journal_title：Vaccine

authors： Xie Y,Li H,Qi X,Ma Y,Yang B,Zhang S,Chang H,Yin X,Li Z

更新日期：2019-03-28 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:Pseudorabies Virus (PRV) is the causative agent of Pseudorabies (PR), also known as Aujeszky's Disease, one of the most important infectious diseases in swine, resulting in huge economic losses to the swine industry globally. The emergence of mutant PRV strains after 2011 resulted in a sharp decrease in the efficacy o...

journal_title：Vaccine

authors： Zhang T,Liu Y,Chen Y,Wang A,Feng H,Wei Q,Zhou E,Zhang G

更新日期：2020-09-03 00:00:00

abstract：:A family of parasite antigens known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is believed to play an important role in the binding of infected erythrocytes to host receptors in the micro-vasculature. Available data advocates the existence of a subset of very adhesive (rosetting, auto-agglutinati...

journal_title：Vaccine

authors： Chen Q,Pettersson F,Vogt AM,Schmidt B,Ahuja S,Liljeström P,Wahlgren M

更新日期：2004-07-29 00:00:00

abstract：:In this study, the potential price for a therapeutic vaccine against Human Papilloma Virus (HPV)-16 & 18 (pre)-malignant cervical lesions is examined. A decision tree model was built in the context of the new Dutch cervical cancer-screening program and includes a primary test for the presence of HPV. Based on data of ...

journal_title：Vaccine

authors： Luttjeboer J,Setiawan D,Cao Q,Cahh Daemen T,Postma MJ

更新日期：2016-12-07 00:00:00

abstract：:The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...

journal_title：Vaccine

authors： Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

更新日期：1996-12-01 00:00:00

abstract：:The search for an effective HIV vaccine continues to be a challenge. Several candidates have been tested in preclinical protocols, and a few have been tested in clinical trials without resounding success. It is unclear why vaccine approaches to control HIV infection have been unsuccessful, but opportunities to dissect...

journal_title：Vaccine

authors： Bansal GP,Leitner WW

更新日期：2010-12-06 00:00:00

abstract：INTRODUCTION:Self-reported measles vaccination coverage is frequently used to inform vaccination strategies in resource-poor settings. However, little is known to what extent this is a reliable indicator of underlying seroprotection, information that could provide guidance ensuring the success of measles control and el...

journal_title：Vaccine

authors： Polonsky JA,Juan-Giner A,Hurtado N,Masiku C,Kagoli M,Grais RF

更新日期：2015-08-26 00:00:00

abstract：BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...

journal_title：Vaccine

authors： Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

更新日期：2015-11-27 00:00:00