Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.

Abstract:

:The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.

journal_name

Vaccine

journal_title

Vaccine

authors

Pyo HM,Masic A,Woldeab N,Embury-Hyatt C,Lin L,Shin YK,Song JY,Babiuk S,Zhou Y

doi

10.1016/j.vaccine.2011.12.083

subject

Has Abstract

pub_date

2012-02-08 00:00:00

pages

1297-304

issue

7

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)02032-9

journal_volume

30

pub_type

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