Burden and trends of type-specific human papillomavirus infections and related diseases in the Asia Pacific region.


:We present the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital areas, and oral cavity and pharynx) in terms of incidence and mortality, for the countries of the Asia Pacific region. The region contains more than half of the world population, and manifests a wide geographic diversity in the prevalence of infection with HPV, and of incidence (and mortality) rates of cancer of the cervix. In general, rates of cancer of the cervix have declined since the 1960's; 67% of cases are associated with HPV-16 and 18. The incidence of other anogenital cancers is low, especially in Asian populations; however, cancers of the mouth and pharynx show a wide range of rates, determined by exposures such as oral tobacco and alcohol and for cancer of the lip, ultraviolet radiation. We also present the estimates of the occurence of genital warts--largely caused by HPV 6 and 11--and the HPV type distribution in the spectrum of women with normal cytology, cervical lesions, and cervical cancer in the region.






Parkin DM,Louie KS,Clifford G




Has Abstract


2008-08-19 00:00:00










26 Suppl 12




  • Proximity to safety-net clinics and HPV vaccine uptake among low-income, ethnic minority girls.

    abstract:PURPOSE:Human Papillomavirus (HPV) vaccine uptake remains low. Although publicly funded programs provide free or low cost vaccines to low-income children, barriers aside from cost may prevent disadvantaged girls from getting vaccinated. Prior studies have shown distance to health care as a potential barrier to utilizin...


    pub_type: 杂志文章


    authors: Tsui J,Singhal R,Rodriguez HP,Gee GC,Glenn BA,Bastani R

    更新日期:2013-04-12 00:00:00

  • Cooperative binding of anti-tetanus toxin monoclonal antibodies: Implications for designing an efficient biclonal preparation to prevent tetanus toxin intoxication.

    abstract::Oligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual MAbs; at the same time, their characteristics can be more efficiently controlled than those of p...


    pub_type: 杂志文章


    authors: Lukic I,Filipovic A,Inic-Kanada A,Marinkovic E,Miljkovic R,Stojanovic M

    更新日期:2018-06-18 00:00:00

  • A randomised vaccine field trial in Kenya demonstrates protection against wildebeest-associated malignant catarrhal fever in cattle.

    abstract::Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the atte...


    pub_type: 杂志文章


    authors: Cook E,Russell G,Grant D,Mutisya C,Omoto L,Dobson E,Lankester F,Nene V

    更新日期:2019-09-20 00:00:00

  • Epitope polarity and adjuvants influence the fine specificity of the humoral response against Semliki Forest virus specific peptide vaccines.

    abstract::The humoral response to synthetic peptide vaccines against Semliki Forest virus (SFV) in H-2d BALB/c mice was investigated with the enzyme linked immunosorbent assay and the pepscan technique. The peptide vaccines consisted of amino acid sequences 240-255 (B) and 137-151 (T) of the E2 membrane protein of SFV colinearl...


    pub_type: 杂志文章


    authors: Fernández IM,Harmsen M,Benaissa-Trouw BJ,Stuij I,Puyk W,Meloen RH,Snippe H,Kraaijeveld CA

    更新日期:1998-10-01 00:00:00

  • Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor of Rhipicephalus microplus.

    abstract::The cattle tick, Rhipicephalus microplus, is regarded as the most economically important ectoparasite of livestock globally. Control is achieved primarily through the use of acaricides. This approach is hampered by the development of resistance to commercial acaricides among cattle tick populations. Vaccination agains...


    pub_type: 杂志文章


    authors: Andreotti R,Cunha RC,Soares MA,Guerrero FD,Leite FP,de León AA

    更新日期:2012-10-19 00:00:00

  • Characterization and optimization of a novel vaccine for protection against Lyme borreliosis.

    abstract::Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...


    pub_type: 杂志文章


    authors: Comstedt P,Hanner M,Schüler W,Meinke A,Schlegl R,Lundberg U

    更新日期:2015-11-04 00:00:00

  • Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.

    abstract::With the aim of studying the molecular diversity of the antigens of a new recombinant vaccine against meningococcus serogroup B, the three genes coding for the main vaccine components GNA (Genome-derived Neisseria Antigen) 1870 (fHbp, factor H Binding Protein), GNA1994 (NadA, Neisseria adhesin A) and GNA2132 were sequ...


    pub_type: 杂志文章


    authors: Bambini S,Muzzi A,Olcen P,Rappuoli R,Pizza M,Comanducci M

    更新日期:2009-05-11 00:00:00

  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection.

    abstract:BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...


    pub_type: 杂志文章,随机对照试验


    authors: Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

    更新日期:2014-12-05 00:00:00

  • Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study.

    abstract:BACKGROUND:Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protection, the safety concerns, or manufacturing challenges hindered successful market approval. Conjugated vaccines have been s...


    pub_type: 杂志文章,随机对照试验


    authors: Hatz CF,Bally B,Rohrer S,Steffen R,Kramme S,Siegrist CA,Wacker M,Alaimo C,Fonck VG

    更新日期:2015-08-26 00:00:00

  • Feasibility of a pilot intervention to reduce pain and syncope during adolescent vaccination.

    abstract:PURPOSE:Vaccines recommended for adolescents are considered safe and effective, however administration may occasionally result in acute pain at the injection site or syncope (fainting). These adverse effects pose a risk to patient safety and are potential barriers to adherence to future vaccinations. We assessed a nove...


    pub_type: 杂志文章


    authors: Henninger ML,Kuntz JL,Firemark AJ,Varga AM,Bok K,Naleway AL

    更新日期:2018-06-22 00:00:00

  • Evaluation of the adequacy of measles laboratory diagnostic tests in the era of accelerating measles elimination in Beijing, China.

    abstract:BACKGROUND:Measles-containing vaccine (MCV) was introduced in 1965 in Beijing and given to the children aged 8m-14y. In population-based surveillance system, real-time polymerase chain reaction (RT-PCR) and immunoglobulin M(IgM) serology tests have been conducted for each suspected case since 2013. We used the surveill...


    pub_type: 杂志文章


    authors: Ma R,Lu L,Suo L,Zhangzhu J,Chen M,Pang X

    更新日期:2019-06-27 00:00:00

  • Inactivated influenza vaccine does not reduce all cause respiratory illness in children with pre-existing medical conditions.

    abstract:BACKGROUND:The effectiveness of inactivated influenza vaccine (IIV) immunization in preventing all cause respiratory illness (RI) in children with pre-existing medical conditions has not been fully established and varies from season to season. This study aims to quantify the overall impact of IIV immunization on primar...


    pub_type: 杂志文章


    authors: de Hoog MLA,Venekamp RP,Meijer A,Sanders EAM,Bruijning-Verhagen PCJL

    更新日期:2020-04-09 00:00:00

  • Compliance with immunization against hepatitis B. A pragmatic study in sexually transmitted disease clinics.

    abstract::The efficacy of a vaccine is based primarily on the adherence of the subject to the immunization schedule. This paper compares the compliance rates (CR) for the third dose of hepatitis B virus (HBV) vaccine given according to one of two vaccination schedules among subjects attending two sexually transmitted disease (S...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Dal-Ré R,González A,Ramirez V,Ballesteros J,del Romero J,Bru F

    更新日期:1995-02-01 00:00:00

  • DNA-based vaccination using Schistosoma japonicum (Asian blood-fluke) genes.

    abstract::We have examined the efficacy of nucleic acid vaccination in inducing immunity to the multicellular parasite, Schistosoma japonicum, a trematode worm responsible for causing schistosomiasis in humans and other mammalian species. A panel of Schistosoma japonicum cDNAs were cloned into eukaryotic expression vectors, inj...


    pub_type: 杂志文章


    authors: Waine GJ,Yang W,Scott JC,McManus DP,Kalinna BH

    更新日期:1997-06-01 00:00:00

  • Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01.

    abstract::Vesicular stomatitis virus (VSV) has been extensively utilized as a viral vector system for the induction of protective immune responses against a variety of pathogens. We constructed recombinant VSVs specifying either the Indiana or Chandipura virus G glycoprotein and expressing the West Nile virus (WNV) envelope (E)...


    pub_type: 杂志文章


    authors: Iyer AV,Pahar B,Boudreaux MJ,Wakamatsu N,Roy AF,Chouljenko VN,Baghian A,Apetrei C,Marx PA,Kousoulas KG

    更新日期:2009-02-05 00:00:00

  • Oral immunisation of laying hens with the live vaccine strains of TAD Salmonella vac E and TAD Salmonella vac T reduces internal egg contamination with Salmonella Enteritidis.

    abstract::Eggs are a major source of human infections with Salmonella. Therefore controlling egg contamination in laying hen flocks is one of the main targets for control programmes. A study was carried out to assess the effect of oral vaccination with TAD Salmonella vac E, TAD Salmonella vac T and with both vaccines TAD Salmon...


    pub_type: 杂志文章


    authors: Gantois I,Ducatelle R,Timbermont L,Boyen F,Bohez L,Haesebrouck F,Pasmans F,van Immerseel F

    更新日期:2006-09-11 00:00:00

  • An IL-15 adjuvant enhances the efficacy of a combined DNA vaccine against Brucella by increasing the CD8+ cytotoxic T cell response.

    abstract::We investigated whether a combined DNA vaccine delivered together with the IL-15 gene (DNA-IL-15(+)) enhanced the immune response against Brucella abortus in mice. Mice vaccinated with DNA-IL-15(+) developed a robust humoral response; Brucella-specific antibodies exhibited a dominance of immunoglobulin G2a (IgG2a) ove...


    pub_type: 杂志文章


    authors: Hu XD,Chen ST,Li JY,Yu DH,Yi-Zhang,Cai H

    更新日期:2010-03-11 00:00:00

  • Can the response to 23-valent pneumococcal vaccine in splenectomised patients be predicted?

    abstract::The 23-valent pneumococcal vaccine has unequal effectiveness in splenectomised patients. We performed a longitudinal study (2005-2008) whose main objective was to characterize the profile of non-responders among splenectomised patients treated at our institution and identify potential predictive indicators of the resp...


    pub_type: 杂志文章


    authors: Llupià A,Vilella A,Costas L,Díez C,Torres F,Yagüe J,Massó M,Muñoz A,Mensa J

    更新日期:2012-03-16 00:00:00

  • Improving adolescent HPV vaccination in a randomized controlled cluster trial using the 4 Pillars™ practice Transformation Program.

    abstract:OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...


    pub_type: 杂志文章,随机对照试验


    authors: Zimmerman RK,Moehling KK,Lin CJ,Zhang S,Raviotta JM,Reis EC,Humiston SG,Nowalk MP

    更新日期:2017-01-03 00:00:00

  • Vaccination program in a resource-limited setting: A case study in the Philippines.

    abstract:OBJECTIVE:Implementing national-level vaccination programs involves long-term investment, which can be a significant financial burden, particularly in resource-limited settings. Although many studies have assessed the economic impacts of providing vaccinations, evidence on the positive and negative implications of huma...


    pub_type: 杂志文章


    authors: Chootipongchaivat S,Chantarastapornchit V,Kulpeng W,Ceria JA,Tolentino NI,Teerawattananon Y

    更新日期:2016-09-14 00:00:00

  • Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study.

    abstract:BACKGROUND:Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific ...


    pub_type: 杂志文章


    authors: Hoest C,Seidman JC,Lee G,Platts-Mills JA,Ali A,Olortegui MP,Bessong P,Chandyo R,Babji S,Mohan VR,Mondal D,Mahfuz M,Mduma ER,Nyathi E,Abreu C,Miller MA,Pan W,Mason CJ,Knobler SL,MAL-ED Network Investigators.

    更新日期:2017-01-11 00:00:00

  • Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B.

    abstract::In this investigation we have generated and defined the immunogenicity of two novel HIV/AIDS vaccine candidates based on the highly attenuated vaccinia virus strains, MVA and NYVAC, efficiently expressing in the same locus (TK) and under the same viral promoter the codon optimized HIV-1 genes encoding gp120 and Gag-Po...


    pub_type: 杂志文章


    authors: Gómez CE,Nájera JL,Jiménez EP,Jiménez V,Wagner R,Graf M,Frachette MJ,Liljeström P,Pantaleo G,Esteban M

    更新日期:2007-04-12 00:00:00

  • Biosafety aspects of the recombinant live oral Vibrio cholerae vaccine strain CVD 103-HgR.

    abstract::The development of live attenuated vaccines, allowing for the safe and effective immunisation at mucosal surfaces, is a strategy of great interest for vaccinologists. The main advantage of this approach over conventional parenteral vaccines is the induction of strong mucosal immune responses, allowing targeting of the...


    pub_type: 杂志文章,评审


    authors: Viret JF,Dietrich G,Favre D

    更新日期:2004-06-23 00:00:00

  • Murine helper T lymphocyte response to influenza virus: recognition of haemagglutinin by subtype-specific and cross-reactive T cell clones.

    abstract::Helper T cel lines specific for influenza virus were established by continuous culture of Mem 71-Bel (H3) virus-immune spleen cells in the presence of virus and antigen-presenting cells and their specificity assessed in proliferation experiments. A line stimulated in vitro with Mem 71-Bel virus was able to proliferate...


    pub_type: 杂志文章


    authors: Katz JM,Brown LE,Ffrench RA,White DO

    更新日期:1985-09-01 00:00:00

  • Immunogenic virus-like particles continuously expressed in mammalian cells as a veterinary rabies vaccine candidate.

    abstract::Rabies is one of the most lethal infectious diseases in the world, with a mortality approaching 100%. There are between 60,000 and 70,000 reported annual deaths, but this is probably an underestimation. Despite the fact that there are vaccines available for rabies, there is a real need of developing more efficacious a...


    pub_type: 杂志文章


    authors: Fontana D,Kratje R,Etcheverrigaray M,Prieto C

    更新日期:2015-08-20 00:00:00

  • Influenza vaccination of future healthcare workers: a cross-sectional study of uptake, knowledge and attitudes.

    abstract::Promotional campaigns recommend immunisation against influenza in healthcare workers (HCWs) but the uptake in this group remains low. We conducted a survey study during the 2008-2009 influenza vaccination period amongst future HCWs to quantify uptake and identify barriers to immunisation. Overall uptake was 8.0% (95% ...


    pub_type: 杂志文章


    authors: Blank DL,Bodansky DM,Forbes A,Garde E,Story F,Roalfe AK,Tait L

    更新日期:2010-06-23 00:00:00

  • A passive cold storage device economic model to evaluate selected immunization location scenarios.

    abstract:BACKGROUND:The challenge of keeping vaccines cold at health posts given the unreliability of power sources in many low- and middle-income countries and the expense and maintenance requirements of solar refrigerators has motivated the development of passive cold storage devices (PCDs), containers that keep vaccines cold...


    pub_type: 杂志文章


    authors: Norman BA,Nourollahi S,Chen SI,Brown ST,Claypool EG,Connor DL,Schmitz MM,Rajgopal J,Wateska AR,Lee BY

    更新日期:2013-10-25 00:00:00

  • Feasibility of case-control and test-negative designs to evaluate dengue vaccine effectiveness in Malaysia.

    abstract:BACKGROUND:The world's first dengue vaccine [Dengvaxia; Sanofi Pasteur] was licensed in 2015 and others are in development. Real-world evaluations of dengue vaccines will therefore soon be needed. We assessed feasibility of case control (CC) and test-negative (TN) design studies for dengue vaccine effectiveness by meas...


    pub_type: 杂志文章


    authors: Nealon J,Lim WY,Moureau A,Linus Lojikip S,Junus S,Kumar S,Nachiappan JP,Devi Sekaran S,Radigue C,Cowling BJ,Ochiai RL,Hss AS

    更新日期:2019-09-16 00:00:00

  • Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma.

    abstract::To evaluate long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma, a prospective study was conducted during 2005-2006 influenza season in six public pediatric clinics in Milan and surroundings, Northern Italy. A single dose (0.5 ml) of a virosomal subunit inactivated inf...


    pub_type: 杂志文章,多中心研究


    authors: Zuccotti G,Amendola A,Viganò A,Pariani E,Zappa A,Pogliani L,Giacomet V,Savarino A,Podestà A,Rottoli A,Tanzi E,Zanetti A,Radaelli G

    更新日期:2007-09-17 00:00:00

  • Antigen dependent and independent mechanisms that sustain serum antibody levels.

    abstract::In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relat...


    pub_type: 杂志文章,评审


    authors: Traggiai E,Puzone R,Lanzavecchia A

    更新日期:2003-06-01 00:00:00