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Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.

Abstract：

:Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. MVA-F or MVA-G vaccination enhanced weight loss during RSV challenge, but did not show the lung eosinophilia seen after FI-RSV vaccination. FI-RSV induced a stronger total RSV IgG response than the MVA recombinants, but very little IgG2a. MVA recombinants induced cytokine responses biased towards IFNgamma and IL-12, while FI-RSV induced strong IL-4/5 responses in the lungs during RSV challenge. Thus, MVA vaccines induce a favourable immune profile in RSV disease but retain the potential to enhance disease.

journal_name

Vaccine

journal_title

Vaccine

authors

Olszewska W,Suezer Y,Sutter G,Openshaw PJ

doi

10.1016/j.vaccine.2004.05.015

subject

Has Abstract

pub_date

2004-11-25 00:00:00

pages

215-21

issue

2

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00420-7

journal_volume

23

pub_type

杂志文章

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