Abstract：
:Plasmodium vivax is responsible for an approximate 35 million yearly human cases of malaria. Unfortunately, due to the low mortality rate associated with it and the difficulties of continuously in vitro culturing of this parasite, vaccine development against this human malaria has been largely neglected. In here, the antigenic properties of the merozoite surface protein 1 gene of P. vivax (PvMSP-1), were studied. Thus, seven recombinant bacterial plasmids coding different regions of the PvMSP-1 protein were constructed and used to immunize BALB/c mice. The results demonstrated that a plasmid encoding the entire N-terminus comprising 682 amino acids and a plasmid encoding the C-terminus including the two juxtaposed epidermal growth factor (EGF)-like domains fused to the Hepatitis B surface antigen, were antigenic. Moreover, the elicited immune responses were similar to those reported for these same PvMSP-1 regions in natural human infections.
journal_name
Vaccinejournal_title
Vaccineauthors
de Oliveira CI,Wunderlich G,Levitus G,Soares IS,Rodrigues MM,Tsuji M,del Portillo HAdoi
10.1016/s0264-410x(99)00176-0subject
Has Abstractpub_date
1999-08-06 00:00:00pages
2959-68issue
23-24eissn
0264-410Xissn
1873-2518pii
S0264-410X(99)00176-0journal_volume
17pub_type
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