Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children.

abstract：:The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deam...

journal_title：Vaccine

authors： Cagigi A,Pensieroso S,Ruffin N,Sammicheli S,Thorstensson R,Pan-Hammarström Q,Hejdeman B,Nilsson A,Chiodi F

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:New, more effective vaccines to prevent tuberculosis (TB) disease are needed urgently. H4:IC31 is an investigational vaccine that contains a fusion protein of the immunodominant antigens TB10.4 and Ag85B, formulated in IC31 adjuvant. We assessed the safety and immunogenicity of H4:IC31 in South African adult...

journal_title：Vaccine

authors： Geldenhuys H,Mearns H,Miles DJ,Tameris M,Hokey D,Shi Z,Bennett S,Andersen P,Kromann I,Hoff ST,Hanekom WA,Mahomed H,Hatherill M,Scriba TJ,H4:IC31 Trial Study Group.,van Rooyen M,Bruce McClain J,Ryall R,de Bruyn G,H4:

更新日期：2015-07-09 00:00:00

abstract：:Human chorionic gonadotropin (hCG) is synthesized soon after fertilization and is essential for embryonic implantation. A vaccine targeting hCG would be an ideal choice for immuno-contraception; an anti-hCG vaccine developed by Talwar et al., has previously undergone Phase II efficacy trials, providing proof of princi...

journal_title：Vaccine

authors： Purswani S,Talwar GP

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:In the immunisation schedule in England and Wales, the 7-valent pneumococcal conjugate vaccine (PCV-7) was replaced by the 13-valent vaccine (PCV-13) in April 2010 after having been used since September 2006. The introduction of PCV-7 was informed by a cost effectiveness analysis using an infectious disease ...

journal_title：Vaccine

authors： van Hoek AJ,Choi YH,Trotter C,Miller E,Jit M

更新日期：2012-11-26 00:00:00

abstract：:Cimetidine (CIM) is an H2-receptor antagonist with a long history of clinical use in peptic ulcer disease. In addition to its inhibitory effect upon gastric acid secretion, CIM can also block histamine-mediated immunosuppression by inhibiting H2 receptors on suppressor T cells. CIM results in immunoaugmentation of bot...

journal_title：Vaccine

authors： Drabick JJ,Tang DB,Moran EE,Trofa AF,Foster JS,Zollinger WD

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:We related seroprevalence and outbreaks data in order to identify factors that could explain the occurrence of outbreaks despite high vaccination coverage in Medellín Colombia. METHODS:Samples from a population seroprevalence data obtained in 2009 in a random survey were analyzed. IgG levels were determined ...

journal_title：Vaccine

authors： Santacruz-Sanmartín E,Hincapié-Palacio D,Ospina MC,Perez-Toro O,Bernal-Restrepo LM,Buitrago-Giraldo S,Lenis-Ballesteros V,Díaz FJ

更新日期：2015-10-13 00:00:00

abstract：:Across the developing world peste des petits ruminants virus places a huge disease burden on agriculture, primarily affecting the production of small ruminant. The disease is most effectively controlled by vaccinating sheep and goats with live attenuated vaccines that provide lifelong immunity. However, the current va...

journal_title：Vaccine

authors： Muniraju M,Mahapatra M,Buczkowski H,Batten C,Banyard AC,Parida S

更新日期：2015-01-09 00:00:00

abstract：:Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

journal_title：Vaccine

authors： Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

更新日期：2009-08-06 00:00:00

abstract：BACKGROUND:Gram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic options. Antibodies to GNB lipopolysaccharide (LPS, or endotoxin) have reduced morbidity and mortality as a result of infection and are not su...

journal_title：Vaccine

authors： Cross AS,Greenberg N,Billington M,Zhang L,DeFilippi C,May RC,Bajwa KK

更新日期：2015-11-27 00:00:00

abstract：:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine can...

journal_title：Vaccine

authors： Oberg AL,McKinney BA,Schaid DJ,Pankratz VS,Kennedy RB,Poland GA

更新日期：2015-09-29 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：:Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...

journal_title：Vaccine

authors： Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

更新日期：2007-01-05 00:00:00

abstract：:Plague, which is initiated by Yersinia pestis infection, is a fatal disease that progresses rapidly and leads to high mortality rates if not treated. Antibiotics are an effective plague therapy, but antibiotic-resistant Y. pestis strains have been reported and therefore alternative countermeasures are needed. In the p...

journal_title：Vaccine

authors： Levy Y,Flashner Y,Tidhar A,Zauberman A,Aftalion M,Lazar S,Gur D,Shafferman A,Mamroud E

更新日期：2011-09-16 00:00:00

abstract：:To provide a safer live challenge strain for use in clinical vaccine trials, a double drug sensitive strain of Leishmania major was derived using advances in gene targeting technology by stably introducing into the chromosome a modified HSV-1 thymidine kinase gene (tk), conferring increased sensitivity to ganciclovir ...

journal_title：Vaccine

authors： Davoudi N,Tate CA,Warburton C,Murray A,Mahboudi F,McMaster WR

更新日期：2005-01-19 00:00:00

abstract：:Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitaliz...

journal_title：Vaccine

authors： McBean AM,Jung K,Hebert PL

更新日期：2006-07-07 00:00:00

abstract：:The protection elicited by the intramuscular injection of two plasmid DNAs encoding Leishmania major cysteine proteinase type I (CPb) and type II (CPa) was evaluated in a murine model of experimental cutaneous leishmaniasis. BALB/c mice were immunized either separately or with a cocktail of the two plasmids expressing...

journal_title：Vaccine

authors： Rafati S,Salmanian AH,Taheri T,Vafa M,Fasel N

更新日期：2001-05-14 00:00:00

abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...

journal_title：Vaccine

authors： Rizzo C,Ajelli M,Merler S,Pugliese A,Barbetta I,Salmaso S,Manfredi P

更新日期：2011-07-22 00:00:00

abstract：:Polysaccharide-protein conjugate vaccines against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae have proven efficacy against radiologically confirmed pneumonia. Measurement of pneumonia incidence provides a platform to estimate of the vaccine-preventable burden. Over 24 months, we conducted surveill...

journal_title：Vaccine

authors： Roca A,Sigaúque B,Quintó L,Morais L,Berenguera A,Corachan M,Ribó JL,Naniche D,Bassat Q,Sacoor Ch,Nhalungo D,Macete E,Schuchat A,Soriano-Gabarró M,Flannery B,Alonso PL

更新日期：2010-07-05 00:00:00

abstract：:Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with OCV under nine distinctive field settings was reported from India, Bangladesh, Vietnam, Guinea, Haiti, and Thailand. Lead...

journal_title：Vaccine

authors： Hall RH,Sack DA

更新日期：2015-01-15 00:00:00

abstract：:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...

journal_title：Vaccine

authors： An SJ,Scaria PV,Chen B,Barnafo E,Muratova O,Anderson C,Lambert L,Chae MH,Yang JS,Duffy PE

更新日期：2018-05-17 00:00:00

abstract：:Virus-like particles (VLPs) are excellent tools for vaccines against pathogens and tumors. They can accommodate foreign polypeptides whose incorporation efficiency and immunogenicity however decrease strongly with the increase of their size. We recently described the CD8(+) T cell immune response against a small forei...

journal_title：Vaccine

authors： Sistigu A,Bracci L,Valentini M,Proietti E,Bona R,Negri DR,Ciccaglione AR,Tritarelli E,Nisini R,Equestre M,Costantino A,Marcantonio C,Santini SM,Lapenta C,Donati S,Tataseo P,Miceli M,Cara A,Federico M

更新日期：2011-04-18 00:00:00

abstract：:Bacterially-displayed peptide libraries have been widely used as an alternative to phage-displayed peptide libraries in screening epitopes or mimotopes of antibodies. Using a protective monoclonal antibody (mAb) 3B9 against hepatitis B virus (HBV) preS protein as target, mimotopes were successfully screened from a Fli...

journal_title：Vaccine

authors： Xin ZT,Liu C,Gao YP,Mao CQ,Zhao A,Zhang J,Shao NS,Ling SG,Xue YN

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...

journal_title：Vaccine

authors： Ben Hadj M,Bouguerra H,Saffar F,Chelly S,Hechaichi A,Talmoudi K,Bahrini A,Chouki T,Hazgui O,Hannachi N,Letaief H,Bellali H,Bahri O,Ben-Alaya-Bouafif N

更新日期：2018-09-18 00:00:00

abstract：:Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccines. We showed that B. subtilis spores promoted the activation of dend...

journal_title：Vaccine

authors： Aps LR,Diniz MO,Porchia BF,Sales NS,Moreno AC,Ferreira LC

更新日期：2015-05-11 00:00:00

abstract：BACKGROUND:1-Dose varicella vaccination was recommended for children in Beijing before November 2012. To further control school-based outbreaks and decrease incidence, a 2-dose vaccination was implemented in 2013. We described the varicella epidemiology and assessed impact of the 2-dose vaccination in Haidian district,...

journal_title：Vaccine

authors： Fu J,Jiang C,Wang J,Zhao F,Ma T,Shi R,Zhao Y,Zhang X

更新日期：2017-04-25 00:00:00

abstract：:Successful vaccination of mice against an otherwise lethal challenge with the Peru strain of Trypanosoma cruzi necessitates the induction of a strong cell mediated immune response. Previously, immunization of mice with the paraflagellar rod proteins from Trypanosoma cruzi90% reduction in parasitemia in immunized mice ...

journal_title：Vaccine

authors： Wrightsman RA,Manning JE

更新日期：2000-01-31 00:00:00

abstract：:One approach to develop a malaria blood-stage vaccine is to target proteins that play critical roles in the erythrocyte invasion of merozoites. The merozoite surface proteins (MSPs) and the erythrocyte-binding antigens (EBAs) are considered promising vaccine candidates, for they are known to play important roles in er...

journal_title：Vaccine

authors： Sakamoto H,Takeo S,Maier AG,Sattabongkot J,Cowman AF,Tsuboi T

更新日期：2012-03-02 00:00:00

abstract：BACKGROUND:Unbiased deep sequencing offers the potential for improved adventitious virus screening in vaccines and biotherapeutics. Successful implementation of such assays will require appropriate control materials to confirm assay performance and sensitivity. METHODS:A common reference material containing 25 target ...

journal_title：Vaccine

authors： Mee ET,Preston MD,Minor PD,Schepelmann S,CS533 Study Participants.

更新日期：2016-04-12 00:00:00

abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...

journal_title：Vaccine

authors： López-Fuertes L,Pérez-Jiménez E,Vila-Coro AJ,Sack F,Moreno S,Konig SA,Junghans C,Wittig B,Timón M,Esteban M

更新日期：2002-12-13 00:00:00

abstract：:The availability of an inactivated hepatitis A virus (HAV) vaccine, and the development of live attenuated virus vaccines against hepatitis represent great advances in the effort to control an important cause of viral hepatitis. There are a number of ways hepatitis A vaccines could be used, depending on the epidemiolo...

journal_title：Vaccine

authors： Kane MA

更新日期：1992-01-01 00:00:00