Abstract:
:Host defence peptides (HDPs) have a variety of potential therapeutic applications, including as vaccine adjuvants, energizing efforts for modification strategies to address their toxicity and instability. Here we compare l, d and RI-Bac2A as vaccine adjuvants. d and RI-Bac2A are equally resistant to proteolytic degradation with no increases in toxicity, however, only RI-Bac2A maintains adjuvant activity of the natural peptide through conserved induction of a Th2 immune response. As HDPs potentiate the adjuvant activity of CpG ODNs, the isomers were also evaluated as co-adjuvants. l-Bac2A has no significant co-adjuvant activity while CpG/RI-Bac2A induces antibody titres significantly higher than CpG (P<0.01), CpG/l-Bac2A (P<0.01) or CpG/d-Bac2A (P<0.01). None of the isomers influence ODN duration or distribution but l and RI-Bac2A promote ODN uptake into B cells and antigen presenting cells. The enhanced adjuvant and co-adjuvant of RI-Bac2A is hypothesized to result from an undefined combination of increased stability and retained biological activity supporting application of retro-inversion to this, and potentially other HDPs.
journal_name
Vaccinejournal_title
Vaccineauthors
Scruten E,Kovacs-Nolan J,Griebel PJ,Latimer L,Kindrachuk J,Potter A,Babiuk LA,Littel-van den Hurk Sv,Napper Sdoi
10.1016/j.vaccine.2010.02.015subject
Has Abstractpub_date
2010-04-09 00:00:00pages
2945-56issue
17eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)00183-0journal_volume
28pub_type
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