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Hepatitis B vaccination: universal vaccination of newborn babies and children at 12 years of age versus high risk groups. A comparison in the field.

Abstract：

:From 1983 to 1993 two anti-hepatitis B vaccinal strategies were adopted in two small towns of Southern Italy at high incidence for HBV infections: Afragola (prevalence of HBsAg carriers of 13.4%) and Frattamaggiore (prevalence of HBsAg carriers of 12.9%). In Afragola, the universal vaccination of infants in their first year of life and adolescents at 12 years of age was carried out, while in Frattamaggiore the selective vaccination of high risk groups of population was introduced. During this study, the changes in the HBV infection endemicity in both towns has been tested by monitoring the incidence of new cases of viral hepatitis B and by the prevalence study of HBsAg carriers prior to and 10 years after the beginning of the immunization programme (1978-1993). The results suggest that universal vaccination of infants in the first year of life and adolescents at 12 years of age has a greater efficiency on the improvement on the endemic status of the infection in the general population in comparison with selective vaccination, when the incidence of new cases of disease and the prevalence of number of HBsAg and anti-HBc carriers in the two populations are considered.

journal_name

Vaccine

journal_title

Vaccine

authors

Da Villa G,Picciottoc L,Elia S,Peluso F,Montanaro F,Maisto T

doi

10.1016/0264-410x(95)00056-7

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

1240-3

issue

13

eissn

0264-410X

issn

1873-2518

pii

0264-410X(95)00056-7

journal_volume

13

pub_type

临床试验,杂志文章

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