A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.

abstract：BACKGROUND:4CMenB (Bexsero), a vaccine developed against invasive meningococcal disease caused by capsular group B strains (MenB), was recently licensed for use by the European Medicines Agency. Assessment of 4CMenB strain coverage in specific epidemiologic settings is of primary importance to predict vaccination impac...

journal_title：Vaccine

authors： Frosi G,Biolchi A,Lo Sapio M,Rigat F,Gilchrist S,Lucidarme J,Findlow J,Borrow R,Pizza M,Giuliani MM,Medini D

更新日期：2013-10-09 00:00:00

abstract：:We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...

journal_title：Vaccine

authors： Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

更新日期：2003-06-02 00:00:00

abstract：:Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...

journal_title：Vaccine

authors： Broadbent AJ,Santos CP,Anafu A,Wimmer E,Mueller S,Subbarao K

更新日期：2016-01-20 00:00:00

abstract：:The efficacy of antibody immunity against Streptococcus pneumoniae stems from the ability of opsonic, serotype (ST)-specific antibodies to pneumococcal capsular polysaccharide (PPS) to facilitate killing of the homologous ST by host phagocytes. However, PPS-specific antibodies have been identified that are protective ...

journal_title：Vaccine

authors： Fabrizio K,Manix C,Tian H,van Rooijen N,Pirofski LA

更新日期：2010-11-03 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:The Polio Endgame strategy includes phased withdrawal of oral poliovirus vaccines (OPV) coordinated with introduction of inactivated poliovirus vaccine (IPV) to ensure population immunity. The impact of IPV introduction into a primary OPV series of immunizations in a developing country is uncertain. METHODS...

journal_title：Vaccine

authors： Mychaleckyj JC,Haque R,Carmolli M,Zhang D,Colgate ER,Nayak U,Taniuchi M,Dickson D,Weldon WC,Oberste MS,Zaman K,Houpt ER,Alam M,Kirkpatrick BD,Petri WA Jr

更新日期：2016-01-12 00:00:00

abstract：:A placebo-controlled, double-blind study on the efficacy of a hepatitis A vaccine (SmithKline Beecham Biologicals) was started in a region of Chile in September 1990, using hepatitis B vaccine as control. A total of 260 healthy children, 6-15 years of age, negative for antibody to hepatitis A virus (anti-HAV), antibod...

journal_title：Vaccine

authors： Riedemann S,Reinhardt G,Frösner GG,Ibarra H,Moraleda L,Hering V,Siegel F,Toledo C,Leon J,Gonzalez JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...

journal_title：Vaccine

authors： Tiro JA,Pruitt SL,Bruce CM,Persaud D,Lau M,Vernon SW,Morrow J,Skinner CS

更新日期：2012-03-16 00:00:00

abstract：:The annual contact for influenza vaccination provides an opportunity to ensure that adults have received other recommended vaccines such as Tdap. Healthy 19-64 year-olds were randomized to receive concomitant administration of Tdap and influenza vaccines or influenza vaccine followed (in 4-6 weeks by) Tdap. 720 partic...

journal_title：Vaccine

authors： McNeil SA,Noya F,Dionne M,Predy G,Meekison W,Ojah C,Ferro S,Mills EL,Langley JM,Halperin SA

更新日期：2007-04-30 00:00:00

abstract：:Because of the serious economic and medical consequences of brucellosis, efforts are to prevent infection of domestic animals through vaccines. Many disadvantages are associated with the current Brucella melitensis Rev.1 vaccine prompting development of alternative vaccines and delivery. Escherichia coli (DH5α) was en...

journal_title：Vaccine

authors： Gupta VK,Radhakrishnan G,Harms J,Splitter G

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. METHODS:The current study in Balb/c mice assessed the levels and ...

journal_title：Vaccine

authors： Kulkarni SP,Thanapati S,Arankalle VA,Tripathy AS

更新日期：2016-11-21 00:00:00

abstract：:We compared the protection afforded by three different DNA application methods against bovine respiratory syncytial virus (BRSV) infection in cattle. A synthetic gene that codes for the G protein of BRSV was inserted into a eukaryotic vector and was used in the vaccine. Intradermal (i.d.) application with a needleless...

journal_title：Vaccine

authors： Schrijver RS,Langedijk JP,Keil GM,Middel WG,Maris-Veldhuis M,Van Oirschot JT,Rijsewijk FA

更新日期：1998-01-01 00:00:00

abstract：:Orally administered recombinant Mycobacterium smegmatis (rM. smegmatis) vaccines represent an attractive option for mass vaccination programmes against various infectious diseases. Therefore, in the present study, we evaluated the capacity of the outer membrane protein 26kDa antigen (Omp26) of Helicobacter pylori (H. ...

journal_title：Vaccine

authors： Lü L,Cao HD,Zeng HQ,Wang PL,Wang LJ,Liu SN,Xiang TX

更新日期：2009-02-11 00:00:00

abstract：:To compare the ability of a native and a recombinant preparation of the major outer membrane protein of Chlamydia trachomatis mouse pneumonitis (MoPn; Ct-nMOMP and Ct-rMOMP) to protect against an intranasal (i.n.) challenge, BALB/c mice were vaccinated by the intramuscular (i.m.) and subcutaneous (s.c.) routes using C...

journal_title：Vaccine

authors： Sun G,Pal S,Weiland J,Peterson EM,de la Maza LM

更新日期：2009-08-06 00:00:00

abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

journal_title：Vaccine

authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

更新日期：1997-08-01 00:00:00

abstract：:Live Shigella flexneri 2a and Shigella sonnei Phase I vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (RNA polymerase) mutation to yield optimal attenuation. These vaccine candida...

journal_title：Vaccine

authors： Linde K,Dentchev V,Bondarenko V,Marinova S,Randhagen B,Bratoyeva M,Tsvetanov Y,Romanova Y

更新日期：1990-02-01 00:00:00

abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...

journal_title：Vaccine

authors： Vipond J,Vipond R,Allen-Vercoe E,Clark SO,Hatch GJ,Gooch KE,Bacon J,Hampshire T,Shuttleworth H,Minton NP,Blake K,Williams A,Marsh PD

更新日期：2006-09-11 00:00:00

abstract：:A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium tuberculosis in a prophylactic setting and also therapeutically reduce the number of bacteria in infected mice. The protective mechanism is thought to be related to Th1-mediated events that result in bacterial killing. To determin...

journal_title：Vaccine

authors： Lima KM,dos Santos SA,Santos RR,Brandão IT,Rodrigues JM Jr,Silva CL

更新日期：2003-12-08 00:00:00

abstract：:The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been...

journal_title：Vaccine

authors： Li Y,Xue M,Yu L,Luo G,Yang H,Jia L,Zeng Y,Li T,Ge S,Xia N

更新日期：2018-04-12 00:00:00

abstract：:Large areas of many developing countries have no grid electricity. This is a serious challenge that threatens the continuity of the vaccine cold chain. The main alternatives to electrically powered refrigerators available for many years--kerosene- and gas-driven refrigerators--are plagued by problems with gas supply i...

journal_title：Vaccine

authors： McCarney S,Robertson J,Arnaud J,Lorenson K,Lloyd J

更新日期：2013-12-09 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe respiratory illness in infants. There are no licensed vaccines to prevent RSV infection. The neonate receives short-term protection from maternally derived antibodies, which, however, can also interfere with the active response to vaccination. A RSV vaccine consisting of...

journal_title：Vaccine

authors： Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

更新日期：2015-03-10 00:00:00

abstract：:Some technological and immunological problems facing the preparation of subunit viral vaccines are discussed. Solubilization of enveloped virus glycoproteins with various detergents has been studied. It has been demonstrated that a novel non-ionic detergent, MESK, can be used to prepare the glycoproteins of enveloped ...

journal_title：Vaccine

authors： Berezin VE,Zaides VM,Isaeva ES,Artamonov AF,Zhdanov VM

更新日期：1988-10-01 00:00:00

abstract：:Anti-tumor vaccination is being evaluated as a prophylactic and therapeutic strategy against cancer growth, dissemination (spreading) or recurrence. Although a large number of studies investigate in detail the identity of antigens to be used for efficacious immune intervention, there have been few studies investigatin...

journal_title：Vaccine

authors： Parvanova I,Rettig L,Knuth A,Pascolo S

更新日期：2011-05-17 00:00:00

abstract：:HIV vaccines of the first generation are, in contrast to most currently licensed vaccines, unlikely to provide sterilizing immunity against infection with HIV. However, they are expected to exert a beneficial effect on the maintenance of CD4 T-cell counts by reducing viral load. There is a recognized need for clarifyi...

journal_title：Vaccine

authors： Fruth U

更新日期：2009-03-23 00:00:00

abstract：:In this study, we attenuated a Chinese LX4-type nephropathogenic infectious bronchitis virus (IBV) strain, CK/CH/LHLJ/04V, by serial passage in embryonated chicken eggs. Based on sequence analysis of the 3'-7kb region, the CK/CH/LHLJ/04V virus population contained subpopulations with a mixture of genetic mutants. The ...

journal_title：Vaccine

authors： Liu S,Zhang X,Gong L,Yan B,Li C,Han Z,Shao Y,Li H,Kong X

更新日期：2009-07-23 00:00:00

abstract：:Herpes zoster, a common disease, has an important impact on the health of adults, particularly the elderly, and the health system. This study evaluated the disease burden and epidemiological characteristics of herpes zoster in Taiwan. Using herpes zoster-related ICD-9-CM codes used on Taiwan's National Health Insuranc...

journal_title：Vaccine

authors： Lin YH,Huang LM,Chang IS,Tsai FY,Lu CY,Shao PL,Chang LY,Varicella-Zoster Working Group.,Advisory Committee on Immunization Practices, Taiwan.

更新日期：2010-02-03 00:00:00

abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

journal_title：Vaccine

authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

更新日期：2006-02-13 00:00:00

abstract：BACKGROUND:Tuberculosis is a major challenge for health care, as options for its treatment and prevention are limited. Therefore, novel approaches, such as DNA vaccination, to both prevent primary infections and the reactivation of latent infections need to be developed. A Mycobacterium marinum infection in adult zebra...

journal_title：Vaccine

authors： Niskanen M,Myllymäki H,Rämet M

更新日期：2020-07-31 00:00:00

abstract：:Aeromonas hydrophila, as a strong Gram-negative bacterium, can infect a wide range of freshwater fish, including common carp Cyprinus carpio, and cause the huge economic loss. To create the effective vaccine is the best way to control the outbreak of the disease caused by A. hydrophila. In this study, a live attenuate...

journal_title：Vaccine

authors： Jiang X,Zhang C,Zhao Y,Kong X,Pei C,Li L,Nie G,Li X

更新日期：2016-06-08 00:00:00

abstract：:We investigated the influence of the site of administration of DNA vaccine on the induced immune response. DNA vaccines were administered by electroporation at three different sites: tibial cranial muscle, abdominal skin and ear pinna. Aiming to draw general conclusions about DNA vaccine delivery, we successively used...

journal_title：Vaccine

authors： Vandermeulen G,Vanvarenberg K,De Beuckelaer A,De Koker S,Lambricht L,Uyttenhove C,Reschner A,Vanderplasschen A,Grooten J,Préat V

更新日期：2015-06-22 00:00:00