Abstract：
:Plasmid DNA encoding herpes simplex virus type-1 glycoprotein D (gD-1) was complexed with asialoorosomucoid conjugated to poly-L-lysine. Following its intravenous injection into BALB/c mice, this complex was targeted to the liver. Liver cells expressing gD-1 were detected immunohistochemically through day 6 post-immunization, while gD-1 DNA was detectable through 14 days post-immunization. Decline of gD-1 expression and detectable gD-1 DNA in the liver correlated with influx of T cells, predominantly CD4(+). The ASOR-poly-L-lysine DNA carrier system promotes hepatic expression of gD-1 and may be useful in vaccination against herpes simplex virus type-1.
journal_name
Vaccinejournal_title
Vaccineauthors
Rogers JV,Hull BE,Fink PS,Chiou HC,Bigley NJdoi
10.1016/s0264-410x(99)00438-7subject
Has Abstractpub_date
2000-02-14 00:00:00pages
1522-30issue
15eissn
0264-410Xissn
1873-2518pii
S0264410X99004387journal_volume
18pub_type
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