Abstract：
:Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Disease exacerbation occurred in study 2 (previously reported). We hypothesized that low protein concentration in study 2's vaccine stimulated a TH2/IgE response that enhanced disease. BRSV-specific IgG1, IgG2, and IgE were measured by ELISA/Western blot from vaccinated/infected, vaccinated/mock infected, mock vaccinated/infected calves in both studies. Results revealed that study 2 calves produced more IgE, particularly to the nucleoprotein (N); IgE among study 2 calves correlated with high clinical scores. In contrast, study 1 calves showed stronger IgG responses to viral proteins.
journal_name
Vaccinejournal_title
Vaccineauthors
Kalina WV,Woolums AR,Berghaus RD,Gershwin LJdoi
10.1016/j.vaccine.2003.10.024subject
Has Abstractpub_date
2004-03-29 00:00:00pages
1465-74issue
11-12eissn
0264-410Xissn
1873-2518pii
S0264410X03007722journal_volume
22pub_type
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