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Evaluation of the stability and immunogenicity of autoclaved and nonautoclaved preparations of a vaccine against American tegumentary leishmaniasis.

Abstract：

:This study was designed to evaluate the immunogenicity of autoclaved and nonautoclaved preparations of a vaccine composed of whole antigens from killed promastigotes of Leishmania amazonensis. Leishmanin skin-test (LST)-negative volunteers were immunized with either autoclaved or nonautoclaved vaccine preparations (32 and 36 subjects, respectively) that had been maintained at 4 degrees C for one year before the onset of this trial. Immunological tests were performed two days before and 40 days after vaccination. The LST conversion rates induced by the autoclaved and nonautoclaved vaccines were significantly different: 59% and 83%, respectively. Leishmania antigen-stimulated proliferative responses of peripheral blood mononuclear cells (PBMC) were significantly higher after vaccination than before vaccination in both groups. The CD8+ subset was predominant over the CD4+ subset among the leishmania-reactive cells after vaccination in both groups. The production of IFN-gamma by the leishmania antigen-stimulated PBMC was significantly higher after vaccination than before vaccination in the group receiving the nonautoclaved vaccine but not in the autoclaved vaccine group. IL-2 was found both before and after vaccination with no differences between its levels in these time points in either group. IL-4 was not detected for either group during the study period.

journal_name

Vaccine

journal_title

Vaccine

authors

De Luca PM,Mayrink W,Alves CR,Coutinho SG,Oliveira MP,Bertho AL,Toledo VP,Costa CA,Genaro O,Mendonça SC

doi

10.1016/s0264-410x(98)00338-7

subject

Has Abstract

pub_date

1999-03-05 00:00:00

pages

1179-85

issue

9-10

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(98)00338-7

journal_volume

17

pub_type

临床试验,杂志文章

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