Abstract:
:The authors examined whether or not cytokines in conjunction with inactivated influenza virus vaccine enhance protection from influenza virus infection in mice. Mice were infected with influenza virus A/PR/8/34 (PR/8) at 10 LD50 by nebulizer after intranasal administration of the cytokine and the vaccine. The survival rate of the group which received both the vaccine and mouse recombinant interferon-beta (MuIFN-beta; 1 x 10(4) IU/mouse) or mouse recombinant interferon-gamma (MuIFN-gamma; 1 x 10(4) IU/mouse) was significantly higher than that of the control group given the vaccine alone. These results show that MuIFN-beta and MuIFN-gamma have an adjuvant effect on this vaccination. In contrast, human recombinant interleukin-2 (HuIL-2) and human recombinant tumour necrosis factor (HuTNF) did not have an adjuvant effect. In order to examine the mechanism of the enhancing effect of MuIFN-gamma on this vaccination, we determined the specific IgA and IgG antibodies present in bronchoalveolar lavage fluid (BALF) and serum, and haemagglutination inhibition (HI) antibody in serum. In the early stage of infection, the titres of IgA and IgG antibodies in the combined group receiving the vaccine with MuIFN-gamma showed a tendency to be higher than those in the group given the vaccine alone. In the late stage of infection, the titre of HI antibody in the group given the vaccine with MuIFN-gamma was significantly lower than that in the group given vaccine alone. It can be concluded from these results that a part of the adjuvant effect of MuIFN-gamma on this vaccination was due to an increase in production of antibodies which neutralized the virus in the lesion.
journal_name
Vaccinejournal_title
Vaccineauthors
Cao M,Sasaki O,Yamada A,Imanishi Jdoi
10.1016/0264-410x(92)90158-gsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
238-42issue
4eissn
0264-410Xissn
1873-2518pii
0264-410X(92)90158-Gjournal_volume
10pub_type
杂志文章相关文献
VACCINE文献大全abstract::The levels of antibody against measles, mumps, and rubella were determined at 5-6 years postimmunization in 468 children vaccinated with two different trivalent vaccines. The proportions of children without detectable antibody levels were 12 and 3.6% for measles (p < 0.001), 14.9 and 7% for mumps (p = 0.006), and 3.3 ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(95)00098-l
更新日期:1995-11-01 00:00:00
abstract:INTRODUCTION:Because of the long interval between infection with high-risk human papillomavirus (hrHPV) and development of cervical cancer surrogate markers for cancer incidence are necessary to monitor vaccine effectiveness (VE). The aim of this study was to calculate VE of HPV16/18 vaccination by annually assessing i...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.04.016
更新日期:2015-05-28 00:00:00
abstract::The costs of developing and producing new-generation vaccines have increased compared to many of the older, "traditional" vaccines because of new technologies and regulatory requirements. While the public sector often supports basic research costs, private manufacturers are usually responsible for the investments in p...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2006.05.042
更新日期:2006-08-31 00:00:00
abstract::Despite extensive research, no unifying concept has satisfactorily explained the cause of the sudden infant death syndrome (SIDS). The details are briefly outlined of some of the evidence supporting the hypothesis that common bacterial toxins are important in the aetiology of SIDS. These bacterial toxins act as trigge...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/0264-410x(94)90102-3
更新日期:1994-03-01 00:00:00
abstract::There is a need for more efficient vaccines to combat viral diseases of Atlantic salmon and other farmed fish. DNA vaccines are highly effective against salmonid rhabdoviruses, but have shown less effect against other viruses. In the present work we have studied if type I IFNs might be used as adjuvants in fish DNA va...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.03.093
更新日期:2015-05-15 00:00:00
abstract::Recently, it was discovered that sialic acid residues on group B streptococcal (GBS) capsular polysaccharides (CPS) are O-acetylated. Since GBS vaccine development has focused on de-O-acetylated CPS, it became germane to investigate the influence of de-O-acetylated GBS vaccine formulations on functional activity of se...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.05.039
更新日期:2009-07-16 00:00:00
abstract::Recombinant hepatitis B surface antigen (HBsAg) particles derived from Chinese hamster ovary (CHO) cells were stored at various conditions for 12-18 months in their naked form or adsorbed to alum (HBV vaccine). The physical, chemical and immunological parameters during storage at -20 degrees C, 4 degrees C, room tempe...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00149-8
更新日期:1999-08-20 00:00:00
abstract::Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.vaccine.2005.04.020
更新日期:2005-07-08 00:00:00
abstract::Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immuno...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.03.047
更新日期:2015-05-05 00:00:00
abstract::We demonstrated earlier that immunization with recombinant Leptospira immunoglobulin like protein A (LigA) induced significant protection against virulent Leptospira interrogans serovar Pomona challenge in hamsters. However, the protective immune mechanism remains unclear. In the present study we demonstrated the prot...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.10.029
更新日期:2008-01-10 00:00:00
abstract::The compatibility, safety and interaction on antibody induction of a combined vaccine application were assessed. Specific pathogen-free cats were vaccinated with either a modified live virus vaccine containing feline calici- (FCV), herpes- (FHV-1), parvovirus (FPV) and Chlamydophila felis (C. felis), an adjuvanted rec...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.10.030
更新日期:2006-03-10 00:00:00
abstract::Using immunopotentiating, reconstituted influenza virosomes (IRIV) as a delivery vehicle, a number of vaccines have been developed. In humans, IRIV-based vaccines containing hepatitis A and influenza antigens have been found to possess enhanced immunogenicity compared to alum-adsorbed vaccine for hepatitis A or commer...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(98)00440-x
更新日期:1999-03-26 00:00:00
abstract::We previously described that an inactivated vaccine against heartwater prepared from Cowdria ruminantium (Crystal Springs strain) organisms and administered in complete Freund's adjuvant (cFA) protected sheep against homologous needle challenge. Further studies, described herein, demonstrated that this vaccine protect...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(98)80120-5
更新日期:1998-07-01 00:00:00
abstract::Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisa...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2019.05.080
更新日期:2019-07-09 00:00:00
abstract::Measles, mumps, rubella and varicella are viral infections which can implicate seriously long-term sequelae of infected individuals or even the unborn child. Vaccines against the individual diseases have long been available. Global measles vaccination is estimated to have prevented more than 20million deaths during 20...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2017.07.051
更新日期:2018-08-28 00:00:00
abstract::In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN-gamma production, the combination of the lectins with SLA antigen did not lea...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.11.067
更新日期:2006-04-05 00:00:00
abstract::Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and develo...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2015.06.119
更新日期:2015-11-25 00:00:00
abstract::This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adju...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.08.048
更新日期:2010-10-08 00:00:00
abstract::Immunization with Mycobacterium bovis Bacille Calmette-Guerin (BCG) did not induce adequate Th1 responses to the latency antigen, HspX of M. tuberculosis. To increase the immunogenicity and protective efficacy of BCG, a recombinant BCG strain over-expressing antigen HspX (rBCG::X) was constructed. The recombinant stra...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.05.063
更新日期:2010-07-19 00:00:00
abstract::Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00199-5
更新日期:1997-03-01 00:00:00
abstract::Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2003.07.013
更新日期:2004-01-02 00:00:00
abstract::In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 yea...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2009.09.073
更新日期:2009-11-23 00:00:00
abstract::Potential endpoints for blood stage malaria vaccine efficacy trials include uncomplicated malaria disease, which is hard to differentiate from other febrile illnesses, and mortality, which requires prohibitively large sample sizes. Strictly defined severe malaria predicts malaria-associated mortality where case fatali...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.01.054
更新日期:2004-08-13 00:00:00
abstract:BACKGROUND:Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. METHODS:IPD cases caused by sero...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.12.056
更新日期:2016-02-03 00:00:00
abstract::Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2020.09.028
更新日期:2020-10-27 00:00:00
abstract::Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(94)90336-0
更新日期:1994-08-01 00:00:00
abstract::To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (f...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00138-9
更新日期:2000-10-15 00:00:00
abstract::Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize mice and goats in conjunction with either Freund's adjuvant or a mura...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90287-8
更新日期:1993-01-01 00:00:00
abstract::Many countries recommend combined tetanus toxoid, reduced diphtheria toxoid and acellular pertussis immunization (Tdap) during pregnancy to stimulate transplacental transmission of pertussis antibodies to newborns. The immune system can be altered during pregnancy, potentially resulting in differing immunization risks...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.06.071
更新日期:2017-07-24 00:00:00
abstract::Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00035-x
更新日期:2002-03-15 00:00:00