当前位置： SCI文献检索 > VACCINE期刊下所有文献 > An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovis.

An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovis.

Abstract：

:The potency of genetic immunization observed in the mouse has demonstrated the utility of DNA vaccines to induce cell-mediated and humoral immune responses. However, it has been relatively difficult to generate comparable responses in non-rodent species. The use of molecular adjuvants may increase the magnitude of these suboptimal responses. In this study, we demonstrate that the co-administration of plasmid-encoded GM-CSF and CD80/CD86 with a novel ESAT-6:CFP10 DNA vaccine against bovine tuberculosis enhances antigen-specific cell-mediated immune responses. ESAT-6:CFP10+GM-CSF+CD80/CD86 DNA vaccinated animals exhibited significant (p<0.01) antigen-specific proliferative responses compared to other DNA vaccinates. Increased expression (p< or =0.05) of CD25 on PBMC from ESAT-6:CFP10+GM-CSF+CD80/CD86 DNA vaccinates was associated with increased proliferation, as compared to control DNA vaccinates. Significant (p<0.05) numbers of ESAT-6:CFP10-specific IFN-gamma producing cells were evident from all ESAT-6:CFP10 DNA vaccinated animals compared to control DNA vaccinates. However, the greatest increase in IFN-gamma producing cells was from animals vaccinated with ESAT-6:CFP10+GM-CSF+CD80/CD86 DNA. In a low-dose aerosol challenge trial, calves vaccinated as neonates with Mycobacterium bovis BCG and ESAT-6:CFP10+GM-CSF+CD80/CD86 DNA exhibited decreased lesion severity in the lung and lung-associated lymph nodes following viruluent M. bovis challenge compared to other vaccinated animals or non-vaccinated controls. These data suggest that a combined vaccine regimen of M. bovis BCG and a candidate ESAT-6:CFP10 DNA vaccine may offer greater protection against tuberculosis in cattle than vaccination with BCG alone.

journal_name

Vaccine

journal_title

Vaccine

authors

Maue AC,Waters WR,Palmer MV,Nonnecke BJ,Minion FC,Brown WC,Norimine J,Foote MR,Scherer CF,Estes DM

doi

10.1016/j.vaccine.2007.03.052

subject

Has Abstract

pub_date

2007-06-11 00:00:00

pages

4735-46

issue

24

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00414-8

journal_volume

25

pub_type

杂志文章,随机对照试验

相关文献

VACCINE文献大全
  • Serum antibacterial and antitoxin responses in clinical cholera caused by Vibrio cholerae O139 Bengal and evaluation of their importance in protection.

    abstract：:Vibrio cholerae O139 Bengal strain was the causative agent of the recent epidemics of cholera in India and Bangladesh. We studied antibacterial and antitoxin immune responses in acute and convalescent phase paired sera collected from seven of these cholera patients. Significant rise in the levels of both antibacterial...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(96)00035-7

    authors： Nandy RK,Albert MJ,Ghose AC

    更新日期：1996-08-01 00:00:00

  • Lasting immune memory against hepatitis B following challenge 10-11 years after primary vaccination with either three doses of hexavalent DTPa-HBV-IPV/Hib or monovalent hepatitis B vaccine at 3, 5 and 11-12 months of age.

    abstract：BACKGROUND:The combined hexavalent diphtheria-tetanus-pertussis-hepatitis B-inactivated poliomyelitis - Haemophilus influenzae type b conjugate vaccine (Infanrix hexa™; DTPa-HBV-IPV/Hib: GlaxoSmithKline Vaccines) induces robust responses to the HBV component when administered at 3, 5 and 11-12 months of age. We assesse...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.06.070

    authors： Avdicova M,Crasta PD,Hardt K,Kovac M

    更新日期：2015-05-28 00:00:00

  • Systematic review of the effects of pertussis vaccines in children.

    abstract：OBJECTIVE:To assess the efficacy and safety of whole-cell and acellular pertussis vaccines administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines. DATA SOURCES:We searched the Cochrane Library, MEDLINE, EMBASE, Biological Abstracts and Science Citation Index to December 2001. Specia...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(02)00770-3

    authors： Jefferson T,Rudin M,DiPietrantonj C

    更新日期：2003-05-16 00:00:00

  • Expanding immunization coverage in rural India: a review of evidence for the role of community health workers.

    abstract：:Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2009.10.108

    authors： Patel AR,Nowalk MP

    更新日期：2010-01-08 00:00:00

  • Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine.

    abstract：:While immune checkpoint inhibition is rapidly becoming standard of care in many solid tumors, immune checkpoint inhibitors (ICIs) fail to induce clinical responses in many patients, presumably due to insufficient numbers of tumor-specific T cells in the tumor milieu. To this end, immunization protocols using viral vec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.02.034

    authors： Albershardt TC,Parsons AJ,Reeves RS,Flynn PA,Campbell DJ,Ter Meulen J,Berglund P

    更新日期：2020-04-09 00:00:00

  • Factors affecting Salmonella-based combination immunotherapy for prevention of type 1 diabetes in non-obese diabetic mice.

    abstract：:We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen. When combined with host cell-expressed TGFβ, the vaccine prevented the onset of diabetes in non-obese diabetic (NOD) mice. Herein, we investigated factors that c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.10.101

    authors： Husseiny MI,Du W,Mbongue J,Lenz A,Rawson J,Kandeel F,Ferreri K

    更新日期：2018-12-18 00:00:00

  • Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis.

    abstract：:In order to evaluate the immunogenicity, safety, and tolerability of the MF-59 adjuvanted seasonal influenza vaccine in children and adolescents with juvenile idiopathic arthritis (JIA) treated with different anti-rheumatic drugs, 60 pediatric patients with JIA (30 treated with disease-modifying anti-rheumatic drugs [...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.083

    authors： Dell'Era L,Corona F,Daleno C,Scala A,Principi N,Esposito S

    更新日期：2012-01-20 00:00:00

  • Overcoming barriers to HPV vaccination: non-inferiority of antibody response to human papillomavirus 16/18 vaccine in adolescents vaccinated with a two-dose vs. a three-dose schedule at 21 months.

    abstract：:For middle and low-income countries, the cost of HPV vaccines remains challenging. We conducted an open-label nonrandomized clinical trial evaluating immune response to the HPV-16/18 AS04-adjuvanted vaccine administered on a standard (months (M) 0-1-6) versus extended schedule (M 0-6-60) at 7, 21, 60, 72 and 120 month...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.vaccine.2013.11.059

    authors： Lazcano-Ponce E,Stanley M,Muñoz N,Torres L,Cruz-Valdez A,Salmerón J,Rojas R,Herrero R,Hernández-Ávila M

    更新日期：2014-02-03 00:00:00

  • The biology of influenza viruses.

    abstract：:The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure ofthe influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in vir...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.07.039

    authors： Bouvier NM,Palese P

    更新日期：2008-09-12 00:00:00

  • Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

    abstract：:Three doses of hepatitis B vaccine were given at 2, 4 and 9 months of age to 220 Senegalese infants living in the Dakar area of Senegal. Half of the infants received 5 micrograms plasma-derived hepatitis B vaccine (Hevac B) and the remainder 20 micrograms mammalian cell-derived recombinant hepatitis B vaccine (GenHeva...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90067-t

    authors： Coursaget P,Bringer L,Sarr G,Bourdil C,Fritzell B,Blondeau C,Yvonnet B,Chiron JP,Jeannée E,Guindo S

    更新日期：1992-01-01 00:00:00

  • Dengue tetravalent DNA vaccine increases its immunogenicity in mice when mixed with a dengue type 2 subunit vaccine or an inactivated Japanese encephalitis vaccine.

    abstract：:We previously developed a dengue tetravalent DNA vaccine that can induce neutralizing antibodies against four dengue viruses in mice. Here, we demonstrated that immunogenicity of our tetravalent vaccine is synergistically increased in mice by co-immunization with dengue type 2 virus (DENV2) subviral extracellular part...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.059

    authors： Imoto J,Konishi E

    更新日期：2007-01-22 00:00:00

  • Overview of cervical cancer screening practices in the extended Middle East and North Africa countries.

    abstract：:National Organized Cervical Cancer Screening (NOCCS) programs are lacking in most of the "Extended Middle East and North Africa" (EMENA) countries. Consequently, most cervical cancers are diagnosed late and are associated with high mortality. In fact, in most of these countries, national mortality data are unknown due...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2012.06.046

    authors： Sancho-Garnier H,Khazraji YC,Cherif MH,Mahnane A,Hsairi M,El Shalakamy A,Osgul N,Tuncer M,Jumaan AO,Seoud M

    更新日期：2013-12-30 00:00:00

  • Vaccines and the regulatory arm of the immune system. An overview from the Trypanosoma cruzi infection model.

    abstract：:The knowledge that the immune system is composed of a regulatory/suppressor arm added a new point of view to better understand the nature of several pathologies including cancer, transplants, infections and autoimmune diseases. The striking discoveries concerning molecules and cells involved in this kind of regulation...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.05.015

    authors： Cabrera G,Marcipar I

    更新日期：2019-06-19 00:00:00

  • A recombinant hybrid outer membrane protein for vaccination against Pseudomonas aeruginosa.

    abstract：:Among the numerous targets which can be used for the development of vaccines against Pseudomonas aeruginosa we focused on the outer membrane proteins OprF and OprI. The C-terminal part of OprF from aa 190 to aa 350 was investigated for its conservation and its localization of B-cell epitopes. A hybrid protein which co...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00420-4

    authors： Knapp B,Hundt E,Lenz U,Hungerer KD,Gabelsberger J,Domdey H,Mansouri E,Li Y,von Specht BU

    更新日期：1999-03-26 00:00:00

  • Improving immunization data quality in Peru and Mexico: Two case studies highlighting challenges and lessons learned.

    abstract：INTRODUCTION:The Global Vaccine Action Plan and the Regional Immunization Action Plan of the Americas call for countries to improve immunization data quality. Immunization information systems, particularly electronic immunization registries (EIRs), can help to facilitate program management and increase coverage. Howeve...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.10.083

    authors： Trumbo SP,Contreras M,García AGF,Díaz FAE,Gómez M,Carrión V,Ruiz KJP,Aquije R,Danovaro-Holliday MC,Velandia-González M

    更新日期：2018-11-29 00:00:00

  • Immunisation with aluminium-containing vaccine of a child with itching nodule following previous vaccination.

    abstract：:Vaccination of children with aluminium sensitisation against diphtheria and tetanus presents a problem, since vaccine without aluminium against these potentially serious infectious diseases is no longer available. This case report presents a 7-month-old boy who, after his second immunisation with DTaP-IPV, developed a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.03.013

    authors： Frederiksen MS,Tofte H

    更新日期：2004-11-15 00:00:00

  • Measurement of Clostridium perfringens beta-toxin production by surface plasmon resonance immunoassay.

    abstract：:A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00282-x

    authors： Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

    更新日期：1998-05-01 00:00:00

  • Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children

    abstract：INTRODUCTION:Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction. METHODS:Active sentinel surveillance for acute...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.02.058

    authors： Enweronu-Laryea CC,Armah G,Sagoe KW,Ansong D,Addo-Yobo E,Diamenu SK,Mwenda JM,Parashar UD,Tate JE

    更新日期：2018-11-12 00:00:00

  • Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization.

    abstract：:Liposome and cholera toxin (CT) are considered to be effective antigen delivery vehicles and adjuvants for mucosal vaccines. The effect of these antigen delivery systems on adjuvant responses to mucosally administered pneumococcal polysaccharide (Pnup) was investigated in this study. Both mucosal (e.g. oral) and syste...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)00198-a

    authors： VanCott JL,Kobayashi T,Yamamoto M,Pillai S,McGhee JR,Kiyono H

    更新日期：1996-04-01 00:00:00

  • A chicken homologue of nectin-4 functions as a measles virus receptor.

    abstract：:Measles virus (MV) vaccine strains use CD46, signaling lymphocyte activation molecule, and nectin-4 in human cells as receptors. Meanwhile, many of them are propagated in primary chicken embryonic fibroblasts (CEFs). Our data revealed that CEFs express a nectin-4 homologous molecule (CEF nectin-4) containing well-cons...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.10.109

    authors： Seki F,Someya K,Komase K,Takeda M

    更新日期：2016-01-02 00:00:00

  • Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals.

    abstract：INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.10.092

    authors： Wilcox CR,Bottrell K,Paterson P,Schulz WS,Vandrevala T,Larson HJ,Jones CE

    更新日期：2018-11-29 00:00:00

  • Safety and immunogenicity of fully liquid DTaP₅-IPV-Hib pediatric combination vaccine (Pediacel®) compared to DTaP₃-HBV-IPV/Hib (Infanrix® Hexa) when coadministered with heptavalent pneumococcal conjugate vaccine (PCV7) as a booster at 11-18 months of age

    abstract：:This study compared the safety and immunogenicity of DTaP₅-IPV-Hib vaccine (followed by monovalent hepatitis B vaccine [HBV]) and DTaP₃-HBV-IPV/Hib vaccines, both coadministered with PCV7, as a fourth-dose booster in toddlers 11-18 months who had a hexavalent vaccine primary series. The fever rate within 4 days of DTa...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2012.05.064

    authors： Berner R,Boisnard F,Thomas S,Mwawasi G,Reynolds D

    更新日期：2012-07-27 00:00:00

  • Peptide-binding assays and HLA II transgenic Abeta degrees mice are consistent and complementary tools for identifying HLA II-restricted peptides.

    abstract：:The identification of MHC class II-restricted peptides has become a priority for the development of peptide-based prophylactic and therapeutic vaccines. The aim of this study was to assess the correlations between peptide-binding assays on purified HLA II molecules and immunization of human HLA II transgenic mice defi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.11.048

    authors： Depil S,Angyalosi G,Moralès O,Delacre M,Delhem N,François V,Georges B,Hammer J,Maillère B,Auriault C,Pancré V

    更新日期：2006-03-20 00:00:00

  • Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.

    abstract：:After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.04.013

    authors： Lecouturier V,Bernard MC,Berry C,Carayol S,Richier E,Boudet F,Heinrichs J

    更新日期：2019-05-06 00:00:00

  • Safety of 9-valent human papillomavirus vaccine administration among pregnant women: Adverse event reports in the Vaccine Adverse Event Reporting System (VAERS), 2014-2017.

    abstract：INTRODUCTION:9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Repor...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.077

    authors： Landazabal CS,Moro PL,Lewis P,Omer SB

    更新日期：2019-02-21 00:00:00

  • The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice.

    abstract：:Recently the urgency of developing a pandemic influenza vaccine has lead to the re-evaluation of the use of whole virus vaccine. We have compared the humoral immune response and the protective efficacy of whole and split influenza virus vaccines in mice. Whole virus vaccine was more immunogenic particularly after the ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.05.040

    authors： Cox RJ,Hovden AO,Brokstad KA,Szyszko E,Madhun AS,Haaheim LR

    更新日期：2006-11-10 00:00:00

  • Implementing universal vaccination programmes: USA.

    abstract：:In the USA, the policy is that all infants receive vaccine against hepatitis B virus (HBV). It is considered that HBV vaccine can be readily integrated into the routine childhood immunization schedule without additional visits. Booster doses of vaccine are not currently recommended because protection lasts for at leas...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)80060-q

    authors： Kane M

    更新日期：1995-01-01 00:00:00

  • Noninvasive vaccination: from the perspective of sonoporation.

    abstract：:Previous noninvasive vaccine submission approaches including respiratory tract-based methods are limited to specific pathogens. Recent developments on ultrasound biology suggest that ultrasound-mediated molecule submission (sonoporation) could be an effective noninvasive approach for gene therapy as well as drug submi...

    journal_title：Vaccine

    pub_type： 信件

    doi：10.1016/j.vaccine.2008.04.049

    authors： Yuan TF

    更新日期：2008-08-05 00:00:00

  • Elucidating the difference in the kinetics of antibody titres of infants in Belgium and Vietnam.

    abstract：:Serological results obtained in a single laboratory from twin-studies on maternal immunisation, in Vietnam and Belgium offer the opportunity to compare antibody kinetics in infants before and after infant vaccination in the presence of vaccine-induced maternal antibodies. Nonlinear mixed-effects models (NLMMs) making ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.09.003

    authors： Tran TMP,Maertens K,Hoang HTT,Van Damme P,Leuridan E,Hens N

    更新日期：2020-10-21 00:00:00

  • Ex vivo human placenta models: transport of immunoglobulin G and its subclasses.

    abstract：:The comparison between fetal and maternal levels of immunoglobulins indicate that the human placenta during pregnancy develops a specific transport mechanism for IgG in the maternal to fetal direction. There are differences for the four subclasses, with preferential transfer of IgG(1) while the slowest transfer is see...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(03)00333-5

    authors： Malek A

    更新日期：2003-07-28 00:00:00