Meningitis epidemics in Africa: a brief overview.

abstract：:Enterohemorrhagic Escherichia coli (EHEC) strains are food borne pathogens with importance in public health. EHEC colonizes the large intestine and causes diarrhea, hemorrhagic colitis and in some cases, life-threatening hemolytic-uremic syndrome (HUS) due to the production of Shiga toxins (Stx). The lack of effective...

journal_title：Vaccine

authors： Garcia-Angulo VA,Kalita A,Torres AG

更新日期：2013-07-11 00:00:00

abstract：:Human papillomavirus type 16 (HPV16)-transformed mouse TC-1 cells are extensively used in the evaluation of efficacy of experimental vaccines against tumours induced by HPVs. As these cells strongly express MHC class I molecules and downregulation of MHC class I surface expression is one of the important mechanisms th...

journal_title：Vaccine

authors： Smahel M,Síma P,Ludvíková V,Marinov I,Pokorná D,Vonka V

更新日期：2003-03-07 00:00:00

abstract：:We previously described that an inactivated vaccine against heartwater prepared from Cowdria ruminantium (Crystal Springs strain) organisms and administered in complete Freund's adjuvant (cFA) protected sheep against homologous needle challenge. Further studies, described herein, demonstrated that this vaccine protect...

journal_title：Vaccine

authors： Mahan SM,Kumbula D,Burridge MJ,Barbet AF

更新日期：1998-07-01 00:00:00

abstract：:Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prev...

journal_title：Vaccine

authors： Ferrantelli F,Rasmussen RA,Hofmann-Lehmann R,Xu W,McClure HM,Ruprecht RM

更新日期：2002-12-19 00:00:00

abstract：:Live attenuated vaccines are usually contraindicated in patients with congenital or acquired immunodeficiency. On the other hand, infections due to wild type virus may be particularly severe in patients with low levels of T cells. The aim of the present study was to evaluate safety and immunogenicity of measles-mumps-...

journal_title：Vaccine

authors： Azzari C,Gambineri E,Resti M,Moriondo M,Betti L,Saldias LR,G Gelli AM,Vierucci A

更新日期：2005-02-25 00:00:00

abstract：:A prospective epidemiologic surveillance of hospitalizations associated with influenza was conducted in order to calculate population-based hospitalization rates. Eligible children were 6 months to 13 years of age and were admitted to one of the two large children's hospitals in the Athens area during two influenza se...

journal_title：Vaccine

authors： Sakkou Z,Stripeli F,Papadopoulos NG,Critselis E,Georgiou V,Mavrikou M,Drossatou P,Constantopoulos A,Kafetzis D,Tsolia M

更新日期：2011-02-01 00:00:00

abstract：:The conventional approach to vaccine development requires cultivation of the pathogenic microorganism and its dissection using biochemical, immunological, and microbiological methods in order to identify the components important for immunity. This method, while successful in many cases, failed to provide a solution fo...

journal_title：Vaccine

authors： Rappuoli R

更新日期：2001-03-21 00:00:00

abstract：:Two inhibitors against haemagglutination by influenza C virus were isolated from pooled sera of normal rats by sequential chromatography on Blue Sepharose CL 6B, Ultrogel AcA 2, and DEAE-cellulose. The two inhibitors were identified as alpha 1-macroglobulin and murinoglobulin by comparison with the authentic samples. ...

journal_title：Vaccine

authors： Kitame F,Nakamura K,Saito A,Sinohara H,Homma M

更新日期：1985-09-01 00:00:00

abstract：:Gram-positive enhancer matrix (GEM) particles, produced from non-genetically modified Lactococcus lactis bacteria have an inherent immunostimulatory activity. It was investigated whether co-administration of GEM particles can reduce the amount of influenza subunit vaccine (HA) necessary to protect mice from viral infe...

journal_title：Vaccine

authors： Saluja V,Visser MR,Ter Veer W,van Roosmalen ML,Leenhouts K,Hinrichs WL,Huckriede A,Frijlink HW

更新日期：2010-11-23 00:00:00

abstract：:Streptococcus pneumoniae is the leading cause of bacterial pneumonia, meningitis and sepsis in children worldwide. Despite available evidence on pneumococcal conjugate vaccine (PCV) impact on pneumonia hospitalizations in children, studies demonstrating PCV impact in morbidity and mortality in middle-income countries ...

journal_title：Vaccine

authors： Suarez V,Michel F,Toscano CM,Bierrenbach AL,Gonzales M,Alencar AP,Ruiz Matus C,Andrus JK,de Oliveira LH

更新日期：2016-09-07 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:The literature on natural infections with Japanese encephalitis virus in Japan and subclinical:clinical infection rates was summarized. To detect natural infections, conventional serologic methods were used in the past, while nonstructural 1 protein-based methods have been used recently. Annual infection rates in huma...

journal_title：Vaccine

authors： Konishi E

更新日期：2009-11-23 00:00:00

abstract：BACKGROUND:As with many high-income countries, vaccination coverage against human papilloma virus (HPV) infection is not high in New Zealand (NZ) at 47% in school-aged girls for three doses. We estimate the health gains, net-cost and cost-effectiveness of the currently implemented HPV national vaccination programme of ...

journal_title：Vaccine

authors： Blakely T,Kvizhinadze G,Karvonen T,Pearson AL,Smith M,Wilson N

更新日期：2014-05-07 00:00:00

abstract：:Streptococcus pneumoniae is one of the leading bacterial pathogens causing invasive disease and non-invasive infections at both extremes of life: in children younger than 5 years and in elderly persons of 65 years or more. Pneumococcal infections result in substantial morbidity and mortality among children under 5 yea...

journal_title：Vaccine

authors： Arguedas A,Soley C,Abdelnour A

更新日期：2011-09-14 00:00:00

abstract：:The necessity of avoiding the use of animals in vaccine potency testing has been widely recognized. The repeatability and reproducibility of the Expected Percentage of Protection (EPP) as a serological potency surrogate for A24 Cruzeiro foot-and-mouth disease virus (FMDV) strain was assessed, and compared with the res...

journal_title：Vaccine

authors： Robiolo B,La Torre J,Maradei E,Beascoechea CP,Perez A,Seki C,Smitsaart E,Fondevila N,Palma E,Goris N,De Clercq K,Mattion N

更新日期：2010-08-31 00:00:00

abstract：:The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than f...

journal_title：Vaccine

authors： Ohara N,Matsuoka M,Nomaguchi H,Naito M,Yamada T

更新日期：2001-02-28 00:00:00

abstract：:A systematic comparison of the immunostimulatory capacity of TLR 2, 3, 4, 5, 7 and 9 agonists and an agonistic CD40-specific antibody was performed in a single long peptide vaccination model. All adjuvants activated DC in vitro but not all induced a strong functional T-cell response in vivo. Optimal clonal CD8(+) T-ce...

journal_title：Vaccine

authors： Welters MJ,Bijker MS,van den Eeden SJ,Franken KL,Melief CJ,Offringa R,van der Burg SH

更新日期：2007-02-09 00:00:00

abstract：:The vaccination of wild animals against rabies has been developed most extensively in Europe. Experiments have demonstrated the efficacy of a vaccinia-rabies recombinant virus administered by the oral route in foxes. The innocuity of this vaccine was tested in the target species as well as in several non-target wild a...

journal_title：Vaccine

authors： Brochier B,Thomas I,Bauduin B,Leveau T,Pastoret PP,Languet B,Chappuis G,Desmettre P,Blancou J,Artois M

更新日期：1990-04-01 00:00:00

abstract：:Effective antigen delivery is one of the most important issues in vaccine development. It has been suggested that adjuvant action results from a depot effect by prolonging the duration of the interaction between antigen and cells, and thus is related to the antigen-releasing properties of emulsion adjuvants. The objec...

journal_title：Vaccine

authors： Yang YW,Wei AC,Shen SS

更新日期：2005-04-08 00:00:00

abstract：:Influenza A viruses pose a substantial threat to the human population whether by purposeful manipulation and release or by the natural process of interspecies transmissions from animal reservoirs. The challenge with preparing for these events with vaccination strategies is that the best forms of protective immunity ta...

journal_title：Vaccine

authors： Ellebedy AH,Webby RJ

更新日期：2009-11-05 00:00:00

abstract：:Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the e...

journal_title：Vaccine

authors： Kennedy LJ,Lunt M,Barnes A,McElhinney L,Fooks AR,Baxter DN,Ollier WE

更新日期：2007-12-12 00:00:00

abstract：:A post hoc analysis was performed using combined data from two Phase I tolerability/immunogenicity studies of monovalent human papillomavirus type 11 (HPV11) or HPV16 L1 virus-like particle (VLP) vaccines. The goal was to determine if the HPV16 L1 VLP vaccine protected against HPV16 infection. Vaccine or placebo was g...

journal_title：Vaccine

authors： Brown DR,Fife KH,Wheeler CM,Koutsky LA,Lupinacci LM,Railkar R,Suhr G,Barr E,Dicello A,Li W,Smith JF,Tadesse A,Jansen KU

更新日期：2004-07-29 00:00:00

abstract：INTRODUCTION:Because of the long interval between infection with high-risk human papillomavirus (hrHPV) and development of cervical cancer surrogate markers for cancer incidence are necessary to monitor vaccine effectiveness (VE). The aim of this study was to calculate VE of HPV16/18 vaccination by annually assessing i...

journal_title：Vaccine

authors： Mollers M,King AJ,Knol MJ,Scherpenisse M,Meijer CJ,van der Klis FR,de Melker HE

更新日期：2015-05-28 00:00:00

abstract：:Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...

journal_title：Vaccine

authors： Lopalco PL,Salleras L,Barbuti S,Germinario C,Bruguera M,Buti M,Domínguez A

更新日期：2000-10-15 00:00:00

abstract：:Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immuniza...

journal_title：Vaccine

authors： Deal C,Pekosz A,Ketner G

更新日期：2013-07-11 00:00:00

abstract：OBJECTIVES:Yearly vaccination against influenza is currently recommended to patients with rheumatoid Arthritis (RA). Antibody and cell-mediated responses are both involved in the defense against influenza. Humoral responses to influenza vaccine are impaired in RA patients treated with rituximab (RTX). The objectives of...

journal_title：Vaccine

authors： Arad U,Tzadok S,Amir S,Mandelboim M,Mendelson E,Wigler I,Sarbagil-Maman H,Paran D,Caspi D,Elkayam O

更新日期：2011-02-11 00:00:00

abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...

journal_title：Vaccine

authors： DeDiego ML,Chiem K,Topham DJ

更新日期：2018-10-15 00:00:00

abstract：:The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(O...

journal_title：Vaccine

authors： Zhang CH,Lu JH,Wang YF,Zheng HY,Xiong S,Zhang MY,Liu XJ,Li JX,Wan ZY,Yan XG,Qi SY,Cui Z,Zhang B

更新日期：2005-05-02 00:00:00

abstract：:In the present study we assessed the capacity of recombinant E. coli- or plasmid-expressed chicken interferons (IFN) and chicken IL-1beta, to exert immunostimulatory activities for humoral immune responses, in day-old and adult chickens. We observed that both recombinant E. coli-expressed chicken IFN-alpha/beta and IF...

journal_title：Vaccine

authors： Schijns VE,Weining KC,Nuijten P,Rijke EO,Staeheli P

更新日期：2000-04-14 00:00:00

abstract：:The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in sequels and high frequency of relapses. The search for new alternatives of treatment is necessary. Previously, we have demonstrated that the hsp65 gene from Mycobacterium le...

journal_title：Vaccine

authors： Ribeiro AM,Bocca AL,Amaral AC,Souza AC,Faccioli LH,Coelho-Castelo AA,Figueiredo F,Silva CL,Felipe MS

更新日期：2010-02-10 00:00:00