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Protection of trivalent inactivated influenza vaccine against hospitalizations among pandemic influenza A (H1N1) cases in Argentina.

Abstract：

:The aim of this study was to estimate the effectiveness of 2009 seasonal trivalent inactivated vaccine in reducing hospitalizations due to the novel influenza A H1N1 virus among positive cases. Data collected from Argentina's national epidemiological surveillance system were analyzed. All patients had a clinical diagnosis and underwent positive serological tests for pandemic influenza A H1N1. Logistic regression was used to estimate vaccine effectiveness to prevent severe cases of the disease, measured as hospitalizations. The adjusted effectiveness of the vaccine was 50% (95% CI: 40-59%). Vaccination was significantly associated with hospitalizations in all age groups, and within groups that had and had not received antiviral treatment. These results suggest that seasonal influenza vaccine might have conferred partial protection against severe cases due to the novel pandemic influenza.

journal_name

Vaccine

journal_title

Vaccine

authors

Orellano PW,Reynoso JI,Carlino O,Uez O

doi

10.1016/j.vaccine.2010.05.051

subject

Has Abstract

pub_date

2010-07-19 00:00:00

pages

5288-91

issue

32

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)00749-8

journal_volume

28

pub_type

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