Abstract：
:The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule versus solution) were within the reference region [0.80-1.25] for area under the curve (AUC(0-infinity): [0.94-0.99]) and maximum observed plasma concentrations (C(max): [0.93-1.08]). Thus, the two formulations were bioequivalent for oseltamivir carboxylate. For pandemic stockpiling of Tamiflu, governments can therefore choose between the capsule formulation alone, the API alone, or quantities of both.
journal_name
Vaccinejournal_title
Vaccineauthors
Brewster M,Smith JR,Dutkowski R,Robson Rdoi
10.1016/j.vaccine.2006.05.080subject
Has Abstractpub_date
2006-11-10 00:00:00pages
6660-3issue
44-46eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00639-6journal_volume
24pub_type
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