当前位置： SCI文献检索 > VACCINE期刊下所有文献 > PolyI:polyC12U adjuvant-combined intranasal vaccine protects mice against highly pathogenic H5N1 influenza virus variants.

PolyI:polyC12U adjuvant-combined intranasal vaccine protects mice against highly pathogenic H5N1 influenza virus variants.

Abstract：

:The highly pathogenic avian H5N1 influenza virus has the potential to incite a global pandemic. Therefore, there is an urgent need to develop effective vaccines against these viruses. Because it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to develop vaccines that will confer cross-protective immunity against variants of the influenza virus. Recently, we reported that the Toll-like receptor 3 agonist, polyI:polyC(12)U (Ampligen), has been proven to be safe in a Phase III human trial, and is an effective mucosal adjuvant for intranasal H5N1 influenza vaccination. Intranasal administration of an Ampligen adjuvanted pre-pandemic H5N1 vaccine (NIBRG14), which was derived from the A/Vietnam/1194/2004 strain, resulted in the secretion of vaccine-specific IgA and IgG in nasal mucosa and serum, respectively, and protected mice against homologous A/Vietnam/1194/2004 and heterologous A/Hong Kong/483/97 and A/Indonesia/6/2005 viral challenge.

journal_name

Vaccine

journal_title

Vaccine

authors

Ichinohe T,Ainai A,Tashiro M,Sata T,Hasegawa H

doi

10.1016/j.vaccine.2009.04.074

subject

Has Abstract

pub_date

2009-10-23 00:00:00

pages

6276-9

issue

45

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00640-9

journal_volume

27

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination.

    abstract：:Although the currently used live attenuated measles vaccines are safe and effective, they are dependent on cold chain maintenance and are often ineffective in young infants due to interference by maternal antibody. Therefore, besides vector-based vaccines, different new generation non-replicating candidate measles vac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00048-8

    authors： Stittelaar KJ,de Swart RL,Vos HW,van Amerongen G,Sixt N,Wild TF,Osterhaus AD

    更新日期：2002-05-15 00:00:00

  • Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na.

    abstract：:Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major cau...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00064-5

    authors： Goestch L,Plotnicky-Gilquin H,Champion T,Beck A,Haeuw JF,Nguyen T,Bonnefoy JY,Corvaïa N

    更新日期：2000-06-01 00:00:00

  • Direct immunization of the abomasum or rectum of goats induces local lymph node responses against Haemonchus contortus mucosal antigens.

    abstract：:We investigated several methods to immunize the abomasum (fourth and gastric stomach) of kid goats by direct (abomasal) or distal (rectal or nasal) routes utilizing mucosal antigens isolated from the abomasal parasite, Haemonchus contortus. Direct (ultrasound guided), immunization of the abomasal mucosa together with ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.003

    authors： Jasmer DP,Brown WC,Parish S

    更新日期：2011-04-05 00:00:00

  • A canine adenovirus type 2 vaccine vector confers protection against foot-and-mouth disease in guinea pigs.

    abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.02.074

    authors： De Vleeschauwer AR,Zhou X,Lefebvre DJ,Garnier A,Watier F,Pignon C,Lacour SA,Zientara S,Bakkali-Kassimi L,De Clercq K,Klonjkowski B

    更新日期：2018-04-12 00:00:00

  • Mouse protection test as a predictor of the protective capacity of synthetic foot-and-mouth disease vaccines.

    abstract：:A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described. Comparisons with titres obtained using conventional serum neutralization tests show that for cattle given synthetic peptide vaccines this in vivo assay is a bet...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90311-s

    authors： Mulcahy G,Pullen LA,Gale C,DiMarchi RD,Doel TR

    更新日期：1991-01-01 00:00:00

  • A Semliki Forest virus replicon vectored DNA vaccine expressing the E2 glycoprotein of classical swine fever virus protects pigs from lethal challenge.

    abstract：:Classical swine fever virus (CSFV) causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. Recently, the replicon of alphaviruses, such as Semliki Forest virus (SFV), has been developed as replicative expression vectors...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.08.020

    authors： Li N,Qiu HJ,Zhao JJ,Li Y,Wang MJ,Lu BW,Han CG,Hou Q,Wang ZH,Gao H,Peng WP,Li GX,Zhu QH,Tong GZ

    更新日期：2007-04-12 00:00:00

  • Investigating adverse events following immunisation with pneumococcal polysaccharide vaccine using electronic General Practice data.

    abstract：BACKGROUND:In early 2011, following an increased number of reports of severe vaccine-related injection site reactions, Australian authorities recommended against administering repeat doses of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in otherwise healthy adults. The aim of this study was to assess a so...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.01.063

    authors： Trinh L,Macartney K,McIntyre P,Chiu C,Dey A,Menzies R

    更新日期：2017-03-13 00:00:00

  • High rates of serological response to a modified hepatitis B vaccination schedule in HIV-infected adults subjects.

    abstract：:We evaluated a modified HBV regimen in a cohort of HIV-infected subjects in Rio de Janeiro, Brazil. HIV-infected subjects with no serologic evidences of previous hepatitis B infection were immunized with 4 doses (40 microg each) of recombinant hepatitis B vaccine given at 0, 1, 2 and 6 months. Blood samples were colle...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.11.066

    authors： Potsch DV,Oliveira ML,Ginuíno C,Miguel JC,Oliveira SA,Silva EF,Moreira RB,Cruz GV,Oliveira AL,Camacho LA,Barroso PF

    更新日期：2010-02-10 00:00:00

  • Peripherally administered sera antibodies recognizing amyloid-β oligomers mitigate Alzheimer's disease-like pathology and cognitive decline in aged 3× Tg-AD mice.

    abstract：:Active and passive immunotherapy targeting amyloid-β (Aβ) may be the most promising strategy to prevent or treat Alzheimer's disease (AD). Previously, immunization with the recombinant 6Aβ15-T antigen generated robust anti-Aβ serum antibodies that strongly recognized Aβ42 oligomers in different mice, markedly reduced ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.02.056

    authors： Wang HC,Yu YZ,Liu S,Zhao M,Xu Q

    更新日期：2016-04-04 00:00:00

  • Expression kinetics of the interleukin-2/immunoglobulin (IL-2/Ig) plasmid cytokine adjuvant.

    abstract：:The development of strategies to augment the immunogenicity of plasmid DNA vaccines is critical for improving their clinical utility. One such strategy involves the coadministration of plasmid cytokine adjuvants with DNA vaccines. Although a large number of plasmid cytokines have shown promise as adjuvants in preclini...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.01.065

    authors： Barouch DH,Truitt DM,Letvin NL

    更新日期：2004-08-13 00:00:00

  • Selection of novel TB vaccine candidates and their evaluation as DNA vaccines against aerosol challenge.

    abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.05.025

    authors： Vipond J,Vipond R,Allen-Vercoe E,Clark SO,Hatch GJ,Gooch KE,Bacon J,Hampshire T,Shuttleworth H,Minton NP,Blake K,Williams A,Marsh PD

    更新日期：2006-09-11 00:00:00

  • Oral vaccination of broiler chickens against necrotic enteritis using a non-virulent NetB positive strain of Clostridium perfringens type A.

    abstract：:Necrotic enteritis (NE) is a severe disease of chickens and turkeys caused by some strains of Clostridium perfringens type A. The disease is well controlled by the use of in-feed antibiotic growth promoters (AGPs). However, due to worldwide public and regulatory pressure to reduce the use of AGPs inter alia, there is ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.030

    authors： Mishra N,Smyth JA

    更新日期：2017-12-14 00:00:00

  • Cloning and characterization of Rhipicephalus appendiculatus voraxinalpha and its effect as anti-tick vaccine.

    abstract：:Male tick-derived voraxinalpha and voraxinbeta, a pair of testicular proteins, are transferred to female via copulation to stimulate female blood feeding in the tick Amblyomma hebraeum (A. hebraeum). Immunized animals with recombinant (r-)voraxinalpha and voraxinbeta have been shown as highly resistant to the tick inf...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.07.072

    authors： Yamada S,Konnai S,Imamura S,Ito T,Onuma M,Ohashi K

    更新日期：2009-10-09 00:00:00

  • Macrophage-derived insulin-like growth factor-1 affects influenza vaccine efficacy through the regulation of immune cell homeostasis.

    abstract：:The level of antibody production induced by a vaccine involves a variety of host factors. One of these, insulin-like growth factor-1 (IGF-1), plays an important role in lymphocyte maturation and antibody expression. Here, we investigated the role of macrophage-derived IGF-1 in the induction of influenza vaccine-specif...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.07.037

    authors： Yoon IS,Park H,Kwak HW,Woo Jung Y,Nam JH

    更新日期：2017-08-24 00:00:00

  • Partial efficacy of a VSV-SIV/MVA-SIV vaccine regimen against oral SIV challenge in infant macaques.

    abstract：:Despite antiretroviral medications, the rate of pediatric HIV-1 infections through breast-milk transmission has been staggering in developing countries. Therefore, the development of a vaccine to protect vulnerable infant populations should be actively pursued. We previously demonstrated that oral immunization of newb...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.051

    authors： Marthas ML,Van Rompay KK,Abbott Z,Earl P,Buonocore-Buzzelli L,Moss B,Rose NF,Rose JK,Kozlowski PA,Abel K

    更新日期：2011-04-12 00:00:00

  • Hepatitis B vaccination among adolescents 13-17 years, United States, 2006-2012.

    abstract：BACKGROUND:Hepatitis B (HepB) vaccination is the most effective measure to prevent HBV infection. Routine HepB vaccination was recommended for infants in 1991 and catch-up vaccination has been recommended for adolescents since in 1995. The purpose of this study is to assess HepB vaccination among adolescents 13-17 year...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.02.021

    authors： Lu PJ,Yankey D,Jeyarajah J,O'Halloran A,Elam-Evans L,Greby SM,Singleton JA,Murphy TV

    更新日期：2015-04-08 00:00:00

  • The feasibility of HIV vaccine efficacy trials among Russian injection drug users.

    abstract：:IDU exposure remains a primary driver of the Russian HIV epidemic, and recent incidence data provide little evidence that this epidemic is slowing. While there are multiple important challenges that need to be further explored before starting vaccine trials, most importantly access to evidence-based drug treatment ser...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.028

    authors： Beyrer C,Baral S,Shaboltas A,Dukhovlinova E,Masharsky A,Verevochkin S,Latkin C,Heimer R,Hoffman I,Kozlov A

    更新日期：2007-10-10 00:00:00

  • Integration of hepatitis B vaccination into the expanded programme on immunization in Chonburi and Chiangmai provinces, Thailand.

    abstract：:Hepatitis B (HB) immunization was introduced as part of the expanded programme on immunization (EPI) in two provinces in Thailand and evaluated over a four year period. Three doses of HB vaccine were offered to 60,980 newborns at birth, 2 and 6 months of age. The overall coverage for complete HB immunization was 90.4%...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00226-5

    authors： Chunsuttiwat S,Biggs BA,Maynard J,Thamapalo S,Laoboripat S,Bovornsin S,Charanasri U,Pinyowiwat W,Kunasol P

    更新日期：1997-04-01 00:00:00

  • Cost-effectiveness of three different vaccination strategies against measles in Zambian children.

    abstract：:The vaccination program in Zambia includes one dose of measles vaccine at 9 months of age. The objective of this study was to compare the cost-effectiveness of the current one-dose measles vaccination program with an immunization schedule in which a second dose is provided either through routine health services or thr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.07.007

    authors： Dayan GH,Cairns L,Sangrujee N,Mtonga A,Nguyen V,Strebel P

    更新日期：2004-01-02 00:00:00

  • Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX.

    abstract：:In the present paper, an in vitro model was established in which the interaction between influenza virus-specific CD8+ T cells and human airway epithelial cells can be studied. To this end, the human lung epithelial cell line A549 was transduced with the HLA-A*0201 gene. This MHC class I allele is involved in the pres...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.01.052

    authors： Rimmelzwaan GF,Boon AC,Geelhoed-Mieras MM,Voeten JT,Fouchier RA,Osterhaus AD

    更新日期：2004-07-29 00:00:00

  • Presentation of caregiver-specific vaccine-related information on National Cancer Institute designated cancer center websites.

    abstract：BACKGROUND:Household-based caregivers serve an important role in protecting the health of cancer patients, who may be vulnerable to infectious diseases due to their cancer treatments. Caregiver preventive care should be prioritized to maintain continuity of care and to reduce potential for transmission of infectious di...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.07.052

    authors： Marellapudi A,King AR,Bednarczyk RA

    更新日期：2020-09-11 00:00:00

  • Critical prevalence of antibodies minimizing vaccination costs for hepatitis A, hepatitis B, varicella, measles and tetanus in adults and adolescents in Catalonia, Spain.

    abstract：:The prevalence of seropositive individuals that makes costs of vaccinating all individuals equal to that for screening and vaccination of susceptible individuals is defined as the critical prevalence of antibodies (p*). Screening and vaccination is more efficient when the prevalence of seropositive individuals (p) in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.03.048

    authors： Plans-Rubió P

    更新日期：2004-09-28 00:00:00

  • STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.

    abstract：BACKGROUND:One of the most concerning public health issues, related to vaccination and disease prevention, is the inability to induce durable immune responses following a single-dose immunization. In this regard, the nature of the inflammatory environment induced by vaccine adjuvants can negatively impact the resulting...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.04.004

    authors： Darling RJ,Senapati S,Kelly SM,Kohut ML,Narasimhan B,Wannemuehler MJ

    更新日期：2019-05-06 00:00:00

  • Is the pneumococcal vaccine Advance Market Commitment motivating innovation and increasing manufacturing capacity? Some preliminary answers.

    abstract：:This paper seeks to give some preliminary evidence on the potential outcome of the pneumococcal vaccine Advance Market Commitment (AMC), with a focus on its impact on innovation in 'emerging' vaccine manufacturers in developing countries. The evidence is derived from a series of interviews with executives at industria...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.01.046

    authors： Plahte J

    更新日期：2012-03-23 00:00:00

  • Individual return to Leydig cell function after GnRH-immunization of boars.

    abstract：:Immunization of boars against GnRH inhibits synthesis of testicular anabolic steroids and the sex odour androstenone. Time between second vaccination and return of Leydig cell function is unknown. Six catheterized boars received the second dose (Improvac) at 26 weeks of age (day 0). Titre, LH, testicular steroids, and...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.05.085

    authors： Claus R,Rottner S,Rueckert C

    更新日期：2008-08-18 00:00:00

  • Immunisation of chickens with live Salmonella vaccines - Role of booster vaccination.

    abstract：:It is accepted that booster vaccinations of chickens with live Salmonella vaccines are essential part of vaccinations schemes to induce an effective adaptive immune response. As manufacturer of registered live Salmonella vaccines recommend different times of booster the question raises whether the duration between the...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.04.041

    authors： Methner U

    更新日期：2018-05-17 00:00:00

  • Towards the rational design of Th1 adjuvants.

    abstract：:Finding adjuvants in order to enhance immune responses against target immunogens has been a major and recurrent issue for the vaccine industry. It is yet to be solved, most particularly in the context of a growing interest in designing new types of vaccines capable of eliciting Th1 immune responses. A review of synthe...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(01)00193-1

    authors： Moingeon P,Haensler J,Lindberg A

    更新日期：2001-08-14 00:00:00

  • Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity.

    abstract：:Many influenza vaccines targeted to hemagglutinin (HA) show efficient immunogenicity for protecting subjects against influenza virus infection. Major antigenic changes to HA molecules can help influenza virus to develop resistance against HA-targeted vaccines. DNA vaccines encoding conserved antigens protect animals a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.02.074

    authors： Ohba K,Yoshida S,Zahidunnabi Dewan M,Shimura H,Sakamaki N,Takeshita F,Yamamoto N,Okuda K

    更新日期：2007-05-22 00:00:00

  • Estimating the public health importance of the CYD-tetravalent dengue vaccine: Vaccine preventable disease incidence and numbers needed to vaccinate.

    abstract：BACKGROUND:To evaluate the potential public health impact of the live attenuated tetravalent Sanofi Pasteur dengue vaccine (CYD-TDV) we analyzed data from the reported clinical trials to calculate vaccine preventable disease incidence (VPDI) and number needed to vaccinate (NNV) based on the licensure indication for per...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.017

    authors： Gessner BD,Wilder-Smith A

    更新日期：2016-04-29 00:00:00

  • The Meningitis Vaccine Project.

    abstract：:Epidemic meningococcal meningitis is an important public health problem in sub-Saharan Africa. Current control measures rely on reactive immunizations with polysaccharide (PS) vaccines that do not induce herd immunity and are of limited effectiveness in those under 2 years of age. Conversely, polysaccharide conjugate ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.04.049

    authors： LaForce FM,Konde K,Viviani S,Préziosi MP

    更新日期：2007-09-03 00:00:00