Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs).

abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

更新日期：1995-07-01 00:00:00

abstract：:We examined the immunogenicity and protective efficacy of a combined DNA vaccine that included six genes encoding immunodominant antigens from Mycobacterium tuberculosis and Brucella abortus. The IL-12 adjuvant system was used for immunization in combination with the combined DNA vaccine (DNA-IL-12(+)). Mice immunized...

journal_title：Vaccine

authors： Yu DH,Li M,Hu XD,Cai H

更新日期：2007-09-17 00:00:00

abstract：:Biological therapy options for the treatment of rheumatic disease target molecules that can affect the cross-talk between innate and adaptive immune responses upon vaccination. Influenza vaccination in children with rheumatic disease has been recommended, but there are only sparse data on the quality of vaccine respon...

journal_title：Vaccine

authors： Laestadius Å,Ingelman-Sundberg HM,Myrberg IH,Verme A,Sundberg E,Schweiger B,Saghafian-Hedengren S,Nilsson A

更新日期：2019-06-19 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea, also known as C. difficile associated diarrhea. The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin. The precise biologic...

journal_title：Vaccine

authors： Wang S,Rustandi RR,Lancaster C,Hong LG,Thiriot DS,Xie J,Secore S,Kristopeit A,Wang SC,Heinrichs JH

更新日期：2016-03-04 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00

abstract：:A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in e...

journal_title：Vaccine

authors： Miconnet I,Pantaleo G

更新日期：2008-07-29 00:00:00

abstract：IMPORTANCE:Disparities in childhood vaccination rates persist. OBJECTIVE:To evaluate the impact of an enriched medical home intervention using community health workers on improving immunization adherence among young children. DESIGN:The intervention group received home visits from trained community health workers to ...

journal_title：Vaccine

authors： Pati S,Ladowski KL,Wong AT,Huang J,Yang J

更新日期：2015-11-17 00:00:00

abstract：:Tattooing has been shown to be very efficient at inducing immunity by vaccination with DNA vaccines. In this study, we examined the usability of tattooing for delivery of peptide vaccines. We compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (HPV16) p...

journal_title：Vaccine

authors： Pokorná D,Poláková I,Kindlová M,Dusková M,Ludvíková V,Gabriel P,Kutinová L,Müller M,Smahel M

更新日期：2009-06-02 00:00:00

abstract：:We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...

journal_title：Vaccine

authors： Mendelson I,Gat O,Aloni-Grinstein R,Altboum Z,Inbar I,Kronman C,Bar-Haim E,Cohen S,Velan B,Shafferman A

更新日期：2005-12-01 00:00:00

abstract：:Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been ...

journal_title：Vaccine

authors： Gayen M,Gupta P,Morazzani EM,Gaidamakova EK,Knollmann-Ritschel B,Daly MJ,Glass PJ,Maheshwari RK

更新日期：2017-06-22 00:00:00

abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...

journal_title：Vaccine

authors： Bento AI,Riolo MA,Choi YH,King AA,Rohani P

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:The recent Ebola outbreak in West Africa led to the use of a variety of different platform technologies for assaying antibodies because of the difficulties of handling the live virus. The same types of method could be applied rapidly to other infections when they emerge. There is a need to compare quantitati...

journal_title：Vaccine

authors： Wilkinson DE,Page M,Mattiuzzo G,Hassall M,Dougall T,Rigsby P,Stone L,Minor P

更新日期：2017-03-01 00:00:00

abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

journal_title：Vaccine

authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

更新日期：2019-11-08 00:00:00

abstract：:Bovine herpesvirus-1 (BHV-1) glycoprotein D (gD), an envelope glycoprotein, engenders mucosal and systemic immunity protecting cattle from viral infection. Production of gD with authentic immunogenicity is required for a subunit vaccine. We placed the truncated BHV-1 gD gene, lacking its putative transmembrane and cyt...

journal_title：Vaccine

authors： Zhu X,Wu S,Letchworth GJ 3rd

更新日期：1997-04-01 00:00:00

abstract：:An ELISA-immunocapture assay was developed for quantification of influenza neuraminidases (N2 and B), with a sensitivity about 10 ng neuramidase(NA)/ml. This sensitive and specific assay was applied to several trivalent vaccine preparations (1997/1998 and 1998/1999). It was shown capable to detect 3.5-6.9 microg NA/ml...

journal_title：Vaccine

authors： Aymard M

更新日期：2002-05-15 00:00:00

abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

journal_title：Vaccine

authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

更新日期：2019-01-03 00:00:00

abstract：:Some technological and immunological problems facing the preparation of subunit viral vaccines are discussed. Solubilization of enveloped virus glycoproteins with various detergents has been studied. It has been demonstrated that a novel non-ionic detergent, MESK, can be used to prepare the glycoproteins of enveloped ...

journal_title：Vaccine

authors： Berezin VE,Zaides VM,Isaeva ES,Artamonov AF,Zhdanov VM

更新日期：1988-10-01 00:00:00

abstract：:On 1 February 2016, in the context of the ongoing Zika virus epidemic, the WHO declared that the recently reported clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern (PHEIC). In response, WHO in collaboration with UNICEF and a working group of indep...

journal_title：Vaccine

authors： Vannice KS,Giersing BK,Kaslow DC,Griffiths E,Meyer H,Barrett A,Durbin AP,Wood D,Hombach J

更新日期：2019-11-28 00:00:00

abstract：:The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction ...

journal_title：Vaccine

authors： Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JW

更新日期：1999-03-05 00:00:00

abstract：:Six adjuvant formulations were compared for their ability to potentiate the primary and memory antibody responses in mice to three companion animal vaccine immunogens--feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and a recombinantly-derived heartworm antigen. The combination of a novel bacterial ...

journal_title：Vaccine

authors： Usinger WR

更新日期：1997-12-01 00:00:00

abstract：:Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower res...

journal_title：Vaccine

authors： Muralidharan A,Russell MS,Larocque L,Gravel C,Sauvé S,Chen Z,Li C,Chen W,Cyr T,Rosu-Myles M,Wang L,Li X

更新日期：2019-07-09 00:00:00

abstract：:HIV-infected children (N=243), >or=5 to <18 years old, receiving stable antiretroviral therapy, were stratified by immunologic status and randomly assigned to receive intranasal live attenuated influenza vaccine (LAIV) or intramuscular trivalent inactivated influenza vaccine (TIV). The safety profile after LAIV or TIV...

journal_title：Vaccine

authors： Levin MJ,Song LY,Fenton T,Nachman S,Patterson J,Walker R,Kemble G,Allende M,Hultquist M,Yi T,Nowak B,Weinberg A

更新日期：2008-08-05 00:00:00

abstract：:Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Dise...

journal_title：Vaccine

authors： Kalina WV,Woolums AR,Berghaus RD,Gershwin LJ

更新日期：2004-03-29 00:00:00

abstract：INTRODUCTION:Intramuscular Immune Serum Globulin (IM ISG) is recommended as post-measles exposure prophylaxis (PEP) when administered within 6days of initial exposure, with variable effectiveness in preventing measles disease. Effectiveness of IM ISG PEP in preventing clinical measles was assessed during a 2014 measles...

journal_title：Vaccine

authors： Bigham M,Murti M,Fung C,Hemming F,Loadman S,Stam R,Van Buynder P,Lem M

更新日期：2017-05-09 00:00:00

abstract：PURPOSE:Patients undergoing chemotherapy often fail to develop robust responses to influenza vaccination. Compared to standard-dose influenza vaccine (SD), high-dose influenza vaccine (HD) has shown improved immunogenicity and protection against influenza illness in adults 65 years and older. This study compared the im...

journal_title：Vaccine

authors： Jamshed S,Walsh EE,Dimitroff LJ,Santelli JS,Falsey AR

更新日期：2016-01-27 00:00:00

abstract：:A major impediment to the development of peptide vaccines has been the inability accurately to mimic conformationally constrained epitopes on the envelope proteins of pathogens. This limitation is further compounded by the fact that several viral envelope proteins exist either as covalently or non-covalently associate...

journal_title：Vaccine

authors： Rao KV,Panda SK,Manivel V

更新日期：1992-01-01 00:00:00

abstract：:Increases in global travel, trade and urbanisation are leading to greater incidence of zoonotic disease, and livestock are often a key link in the spread of disease to humans. As such, livestock vaccination strategies, as a part of broader biosecurity solutions, are critical to both animal and human health. Importantl...

journal_title：Vaccine

authors： Layton DS,Choudhary A,Bean AGD

更新日期：2017-10-20 00:00:00

abstract：:There is accumulating evidence that many invertebrates including insects can acquire enhanced immune protection against subsequently pathogens infection through immune priming. However, whether the toxin protein from pathogenic bacteria can induce such priming response remains unclear. Here we cloned, expressed and pu...

journal_title：Vaccine

authors： Wu G,Yi Y,Sun J,Li M,Qiu L

更新日期：2015-11-17 00:00:00

abstract：:The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Ad...

journal_title：Vaccine

authors： Morefield GL,HogenEsch H,Robinson JP,Hem SL

更新日期：2004-05-07 00:00:00

abstract：:The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...

journal_title：Vaccine

authors： Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

更新日期：2008-07-04 00:00:00